Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Niels L. Mulder"'
Autor:
Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Esther Verkade, Melany K. Veentjer, Theo H. van Dijk, Vincent W. Bloks, Rick Havinga, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2495 (2023)
Bile acids (BAs) and their signaling pathways have been identified as therapeutic targets for liver and metabolic diseases. We generated Cyp2c70−/− (KO) mice that were not able to convert chenodeoxycholic acid into rodent-specific muricholic acid
Externí odkaz:
https://doaj.org/article/6f2bbd3a48534fe2b250f2e7649963fb
Autor:
Jan Freark de Boer, Hilde D. de Vries, Anna Palmiotti, Rumei Li, Marwah Doestzada, Joanne A. Hoogerland, Jingyuan Fu, Anouk M. La Rose, Marit Westerterp, Niels L. Mulder, Milaine V. Hovingh, Martijn Koehorst, Niels J. Kloosterhuis, Justina C. Wolters, Vincent W. Bloks, Joel T. Haas, David Dombrowicz, Bart Staels, Bart van de Sluis, Folkert Kuipers
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1045-1069 (2021)
Background and Aims: Bile acids (BAs) aid intestinal fat absorption and exert systemic actions by receptor-mediated signaling. BA receptors have been identified as drug targets for liver diseases. Yet, differences in BA metabolism between humans and
Externí odkaz:
https://doaj.org/article/7532521445514e72b3e86eded4106a3d
Autor:
Jan Freark de Boer, Esther Verkade, Niels L. Mulder, Hilde D. de Vries, Nicolette Huijkman, Martijn Koehorst, Theo Boer, Justina C. Wolters, Vincent W. Bloks, Bart van de Sluis, Folkert Kuipers
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 291-305 (2020)
Bile acids (BAs) facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5. These receptors are targets for therapy in cholestati
Externí odkaz:
https://doaj.org/article/1b56e3171b514bbe9f8130fcfd347f64
Autor:
Jeanet G. Nieuwenhuis, Peter Lepping, Niels L. Mulder, Henk L. I. Nijman, Mike Veereschild, Eric O. Noorthoorn
Publikováno v:
BJPsych Open, Vol 7 (2021)
Background It has been suggested that people with intellectual disabilities have a higher likelihood to develop psychiatric disorders, and that their treatment prognosis is relatively poor. Aims We aimed to establish the prevalence of intellectual d
Externí odkaz:
https://doaj.org/article/6b2bff0648074119bf31e7a6dc439651
Autor:
Rumei Li, Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Yue Zhang, Kim Kats, Vincent W. Bloks, Jingyuan Fu, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100134- (2021)
Bile acids (BAs) play important roles in lipid homeostasis, and BA signaling pathways serve as therapeutic targets for nonalcoholic fatty liver disease (NAFLD). Recently, we generated cytochrome P450, family 2, subfamily C, polypeptide 70 (Cyp2c70−
Externí odkaz:
https://doaj.org/article/f8cb60c473764338b6419affd52446ef
Autor:
Roos E. Ruijne, Astrid M. Kamperman, Kylee Trevillion, Carlo Garofalo, Femke E. Jongejan, Stefan Bogaerts, Louise M. Howard, Niels L. Mulder
Publikováno v:
BJPsych Open, Vol 5 (2019)
BackgroundDespite the high prevalence of domestic violence and abuse (DVA) among patients with psychiatric conditions, detection rates are low. Limited knowledge and skills on DVA in mental healthcare (MHC) professionals might contribute to poor iden
Externí odkaz:
https://doaj.org/article/a71f78409493439794ede6c3a288daae
Autor:
Hilde D. de Vries, Anna Palmiotti, Rumei Li, Milaine V. Hovingh, Niels L. Mulder, Martijn Koehorst, Vincent W. Bloks, Tim van Zutphen, Folkert Kuipers, Jan Freark de Boer
Publikováno v:
Pediatric Research. Nature Publishing Group
Background Cyp2c70-/- mice with a human-like bile acid (BA) composition display features of neonatal cholestasis. We assessed whether perinatal ursodeoxycholic acid (UDCA) exposure prevents neonatal cholestasis in Cyp2c70-/- mice and reduces cholangi
Autor:
Janine K. Kruit, Niels L. Mulder, Angelika Jurdzinski, Bart J. L. Eggen, Laura J. Niedernhofer, Ana P. Huerta Guevara, Tokio Sano, Tania Rozgaja Stallons, Theo H. van Dijk, Johan W. Jonker, Sara J. McGowan, Melissa Kazantzis
Publikováno v:
Metabolism: clinical and experimental
Metabolism: Clinical and Experimental, 117:154711, 1-9. W B SAUNDERS CO-ELSEVIER INC
Metabolism: Clinical and Experimental, 117:154711, 1-9. W B SAUNDERS CO-ELSEVIER INC
Background: Type 2 diabetes (T2DM) is an age-associated disease characterized by hyperglycemia due to insulin resistance and decreased beta-cell function. DNA damage accumulation has been associated with T2DM, but whether DNA damage plays a role in t
Autor:
Bart van de Sluis, Theo Boer, Jan Freark de Boer, Justina C. Wolters, Esther Verkade, Hilde D. de Vries, Vincent W. Bloks, Niels L. Mulder, Nicolette C. A. Huijkman, Folkert Kuipers, Martijn Koehorst
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 291-305 (2020)
Journal of Lipid Research
Journal of Lipid Research, 61(3), 291-305. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Lipid Research
Journal of Lipid Research, 61(3), 291-305. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Bile acids (BAs) facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5. These receptors are targets for therapy in cholestati
Publikováno v:
Journal of endocrinology, 240(2), 123-132. BIOSCIENTIFICA LTD
MicroRNAs have emerged as essential regulators of beta cell function and beta cell proliferation. One of these microRNAs, miR-132, is highly induced in several obesity models and increased expression of miR-132 in vitro modulates glucose-stimulated i