Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Niels Heinz"'
Autor:
Sebastian Dütting, Frederique Gaits-Iacovoni, David Stegner, Michael Popp, Adrien Antkowiak, Judith M.M. van Eeuwijk, Paquita Nurden, Simon Stritt, Tobias Heib, Katja Aurbach, Oguzhan Angay, Deya Cherpokova, Niels Heinz, Ayesha A. Baig, Maximilian G. Gorelashvili, Frank Gerner, Katrin G. Heinze, Jerry Ware, Georg Krohne, Zaverio M. Ruggeri, Alan T. Nurden, Harald Schulze, Ute Modlich, Irina Pleines, Cord Brakebusch, Bernhard Nieswandt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Düttinget al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting
Externí odkaz:
https://doaj.org/article/9a41c7db2ef649429ea7c2db2ddf72fe
Autor:
Christian Milde, Luise Roser, Marcel G. E. Rommel, Franziska Schenk, Ute Modlich, Keven Hoerster, Niels Heinz, Saskia Kohlscheen
Publikováno v:
Experimental hematology, 85:33-46
Thrombopoietin (THPO) and its receptor myeloproliferative leukemia virus oncogene (MPL) regulate hematopoietic stem cell (HSC) quiescence and maintenance, but also megakaryopoiesis. Thrombocytopenias or aplastic anemias can be treated today with THPO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5079dfc9dc1570b51719b9236aaae6
https://doi.org/10.1016/j.exphem.2020.04.006
https://doi.org/10.1016/j.exphem.2020.04.006
Autor:
Attila Sebe, Kaj E C Blokland, Ute Modlich, Niels Heinz, Katharina Cullmann, Franziska Schenk, Zoltán Ivics
Publikováno v:
Biomaterials. 192
Genetic modification of induced pluripotent stem (iPS) cells may be necessary for the generation of effector cells for cellular therapies. Hereby, it can be important to induce transgene expression at restricted and defined time windows, especially i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db8cb837381e25ffa522b088da77aef
https://pubmed.ncbi.nlm.nih.gov/30508767
https://pubmed.ncbi.nlm.nih.gov/30508767
Autor:
Bernhard Schiedlmeier, Axel Schambach, Niels Heinz, Ute Modlich, Adrian Schwarzer, Birgitta Ehrnström
Publikováno v:
Stem Cells Translational Medicine. 4:1064-1072
Human cord blood (CB)-derived hematopoietic stem cells (HSCs) are an interesting source for HSC transplantation. However, the number of collected CB-HSCs is often too low for one transplantation; therefore, ex vivo expansion of CB-HSCs is desirable.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6676eee9c3c2a87cd0ee62678a4e329c
https://doi.org/10.5966/sctm.2014-0284
https://doi.org/10.5966/sctm.2014-0284
Autor:
Axel Schambach, Niels Heinz, Michael Heuser, K Czarnecki, M Heise, R Phaltane, Thomas Moritz, Sebastian Brennig, Nico Lachmann, Dagmar Dilloo, Volkhard Kaever, Henning Kempf
Publikováno v:
Leukemia. 29:2266-2269
Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5cfe44b1e21981e67d2a3a1e930d64
https://doi.org/10.1038/leu.2015.108
https://doi.org/10.1038/leu.2015.108
Autor:
Dirk Wedekind, Jessica Herbst, Martin Hapke, Rolf Baumann, Axel Schambach, Dario A. A. Vignali, Martin Sauer, Niels Heinz, Bernhard Schiedlmeier, Bruce R. Blazar, M.R.M. van den Brink, Sayed Shahabuddin Hoseini
Publikováno v:
Leukemia. 29:1530-1542
Co-transplantation of hematopoietic stem cells with those engineered to express leukemia-reactive T cell receptors (TCRs) and differentiated ex vivo into precursor T cells (preTs) may reduce the risk of leukemia relapse. Since expression of potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f7777d9fa980c416b2bc92cdebb6ab
https://doi.org/10.1038/leu.2015.20
https://doi.org/10.1038/leu.2015.20
Autor:
Angel Raya, Oscar Quintana-Bustamante, V. Moleiro, Juan A. Bueren, Elena Almarza, Guillermo Guenechea, Ute Modlich, José C. Segovia, R. Chinchon, Juan Carlos Izpisúa-Belmonte, Melanie Galla, Samuel Navarro, M.L. Lozano, Enrique Samper, Tobias Maetzig, Yaima Torres, Paula Río, Bernhard Schiedlmeier, Niels Heinz, F.J. Molina-Estevez, Gustavo Mostoslavsky
Publikováno v:
STEM CELLS; Vol 32
Fanconi anemia (FA) is a complex genetic disease associated with a defective DNA repair pathway known as the FA pathway. In contrast to many other FA proteins, BRCA2 participates downstream in this pathway and has a critical role in homology-directed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8aafe4e30675ed392614570d5bf737
https://doi.org/10.1002/stem.1586
https://doi.org/10.1002/stem.1586
Autor:
Axel Schambach, Sandra Broll, Raju Kandimalla, Markus Heine, Jürgen Bode, Niels Heinz, Kristina Nehlsen, Stefanie Binius
Publikováno v:
Minicircle and Miniplasmid DNA Vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0cd01ff089fa5e0209a53ace0e9c16
https://doi.org/10.1002/9783527670420.ch8
https://doi.org/10.1002/9783527670420.ch8
Autor:
L. J. Latorre‐Rey, Sabine Wintterle, Susanne Wingert, Saskia Kohlscheen, Bernhard Nieswandt, Michael A. Rieger, Sebastian Dütting, F. Schenk, Niels Heinz, T. Abel, Ute Modlich
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 15(2)
Essentials Platelet phenotypes can be modified by lentiviral transduction of hematopoietic stem cells. Megakaryocyte-specific lentiviral vectors were tested in vitro and in vivo for restricted expression. The glycoprotein 6 vector expressed almost ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc1a52fa77674c66a82ab62173b000a
https://pubmed.ncbi.nlm.nih.gov/27930847
https://pubmed.ncbi.nlm.nih.gov/27930847
Autor:
Eva Nilsson, Stefan Karlsson, Christopher Baum, Ulrika Blank, Bernhard Schiedlmeier, Birgitta Ehrnström, Niels Heinz, Ann C.M. Brun
Publikováno v:
European Journal of Haematology; Vol 89
European Journal of Haematology
European Journal of Haematology
OBJECTIVES: Methods to expand hematopoietic stem cells (HSCs) ex vivo encompass an attractive approach that would substantially broaden the clinical applicability of HSCs derived from cord blood. Recently, members of the Angiopoietin-like (Angptl) fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce4294f9098a7d91a9f8ce85832755d