Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Niels Heemskerk"'
Autor:
Lisa te Molder, Maaike Kreft, Niels Heemskerk, Joyce Schuring, Jose M. de Pereda, Kevin Wilhelmsen, Arnoud Sonnenberg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract In epithelial cancers, the epidermal growth factor receptor (EGFR) and integrin α6β4 are frequently overexpressed and found to synergistically activate intracellular signaling pathways that promote cell proliferation and migration. In canc
Externí odkaz:
https://doaj.org/article/87dfb450d8f447a4ac605d2d0ef1c327
Autor:
Amelie Bos, Esil Aleyd, Lydia P. E. van der Steen, P. J. Winter, Niels Heemskerk, Stephan M. Pouw, Louis Boon, Rene J. P. Musters, Jantine E. Bakema, Cassian Sitaru, Michel Cogné, Marjolein van Egmond
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunoglobulin A (IgA) is generally considered as a non-inflammatory regulator of mucosal immunity, and its importance in diversifying the gut microbiota is increasingly appreciated. IgA autoantibodies have been found in several autoimmune or chronic
Externí odkaz:
https://doaj.org/article/4af949826139448faa844c9e290be8b0
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Vascular abnormalities in tumors have a major impact on the immune microenvironment in tumors. The consequences of abnormal vasculature include increased hypoxia, acidosis, high intra-tumoral fluid pressure, and angiogenesis. This introduces an immun
Externí odkaz:
https://doaj.org/article/013f6d9a138d45a5893baa1ee0c46533
Autor:
Niels Heemskerk, Lilian Schimmel, Chantal Oort, Jos van Rijssel, Taofei Yin, Bin Ma, Jakobus van Unen, Bettina Pitter, Stephan Huveneers, Joachim Goedhart, Yi Wu, Eloi Montanez, Abigail Woodfin, Jaap D. van Buul
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Endothelial cells can support leukocyte extravasation without causing vascular leakage, but the exact mechanism underlying this process has not been fully elucidated. Here the authors show that it is regulated through actomyosin-based endothelial por
Externí odkaz:
https://doaj.org/article/6c3133e60cd84e1f9874b018a721bd0a
Autor:
Simran Grewal, Rianne Korthouwer, Marijn Bögels, Rens Braster, Niels Heemskerk, Andries E. Budding, Stephan M. Pouw, Jack van Horssen, Marjolein Ankersmit, Jeroen Meijerink, Petrousjka van den Tol, Steven Oosterling, Jaap Bonjer, Nuray Gül, Marjolein van Egmond
Publikováno v:
OncoImmunology, Vol 7, Iss 9 (2018)
Surgical resection of the primary tumor provides the best chance of cure for patients with colorectal carcinoma (CRC). However, bacterial translocation during intestinal surgery has been correlated with poor long-term oncological outcome. Therefore,
Externí odkaz:
https://doaj.org/article/012be5ae30f845d7b957e6456e8bd1b0
Autor:
José M. de Pereda, Arnoud Sonnenberg, Lisa te Molder, Kevin Wilhelmsen, Niels Heemskerk, Joyce Schuring, Maaike Kreft
Publikováno v:
Scientific Reports, 11(1):8675. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
te Molder, L, Kreft, M, Heemskerk, N, Schuring, J, de Pereda, J M, Wilhelmsen, K & Sonnenberg, A 2021, ' EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines ', Scientific Reports, vol. 11, no. 1, 8675, pp. 8675 . https://doi.org/10.1038/s41598-021-88134-6
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
te Molder, L, Kreft, M, Heemskerk, N, Schuring, J, de Pereda, J M, Wilhelmsen, K & Sonnenberg, A 2021, ' EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines ', Scientific Reports, vol. 11, no. 1, 8675, pp. 8675 . https://doi.org/10.1038/s41598-021-88134-6
© The Author(s) 2021.
In epithelial cancers, the epidermal growth factor receptor (EGFR) and integrin α6β4 are frequently overexpressed and found to synergistically activate intracellular signaling pathways that promote cell proliferation and
In epithelial cancers, the epidermal growth factor receptor (EGFR) and integrin α6β4 are frequently overexpressed and found to synergistically activate intracellular signaling pathways that promote cell proliferation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570c9a1b0856b2178bee42e37c15eac7
https://research.vumc.nl/en/publications/d95793b7-e664-4752-8851-ba331fd43120
https://research.vumc.nl/en/publications/d95793b7-e664-4752-8851-ba331fd43120
Autor:
Marieke H. Heineke, Paula J. Winter, Niels Heemskerk, Suzanne N. Lissenberg-Thunnissen, Marco de Donatis, Dennis Y. Gout, A. Robin Temming, Cornelis W. Tuk, Thies Rösner, Marijn Bögels, Tessa Hellingman, Mandy Gruijs, Marjolein van Egmond, Jantine E. Bakema, Arthur E. H. Bentlage, Gestur Vidarsson, Thomas Valerius
Publikováno v:
Journal of Clinical Investigation, 131(6), 1. The American Society for Clinical Investigation
J Clin Invest
Heemskerk, N, Gruijs, M, Temming, A R, Heineke, M H, Gout, D Y, Hellingman, T, Tuk, C W, Winter, P J, Lissenberg-Thunnissen, S, Bentlage, A E, de Donatis, M, Bögels, M, Rösner, T, Valerius, T, Bakema, J E, Vidarsson, G & van Egmond, M 2021, ' Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity ', Journal of Clinical Investigation, vol. 131, no. 6, e134680 . https://doi.org/10.1172/JCI134680
Journal of Clinical Investigation, 131(6):e134680. The American Society for Clinical Investigation
Journal of clinical investigation, 131(6):e134680. The American Society for Clinical Investigation
J Clin Invest
Heemskerk, N, Gruijs, M, Temming, A R, Heineke, M H, Gout, D Y, Hellingman, T, Tuk, C W, Winter, P J, Lissenberg-Thunnissen, S, Bentlage, A E, de Donatis, M, Bögels, M, Rösner, T, Valerius, T, Bakema, J E, Vidarsson, G & van Egmond, M 2021, ' Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity ', Journal of Clinical Investigation, vol. 131, no. 6, e134680 . https://doi.org/10.1172/JCI134680
Journal of Clinical Investigation, 131(6):e134680. The American Society for Clinical Investigation
Journal of clinical investigation, 131(6):e134680. The American Society for Clinical Investigation
Most clinically used anticancer mAbs are of the IgG isotype, which can eliminate tumor cells through NK cell-mediated antibody-dependent cellular cytotoxicity and macrophage-mediated antibody-dependent phagocytosis. IgG, however, ineffectively recrui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253c7d45fb6c5b38d74a0986dbf8bca1
https://dspace.library.uu.nl/handle/1874/425229
https://dspace.library.uu.nl/handle/1874/425229
Publikováno v:
Small GTPases, 8(1), 1-15. Landes Bioscience
Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens. It serves as a protective response that involves leukocytes, blood vessels and molecular mediators with the purpose to eliminate the initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a9712e96e1ca285bbf5749a3449412
https://doi.org/10.1080/21541248.2016.1197872
https://doi.org/10.1080/21541248.2016.1197872
Autor:
Marjolein van Egmond, Nuray Gül, Marjolein Ankersmit, Stephan M. Pouw, Jack van Horssen, Jaap Bonjer, Rens Braster, Petrousjka van den Tol, Niels Heemskerk, Simran Grewal, Marijn Bögels, Steven J. Oosterling, Rianne M. Korthouwer, Jeroen Meijerink, Andries E. Budding
Publikováno v:
Grewal, S, Korthouwer, R, Bögels, M, Braster, R, Heemskerk, N, Budding, A E, Pouw, S M, van Horssen, J, Ankersmit, M, Meijerink, J, van den Tol, P, Oosterling, S, Bonjer, J, Gül, N & van Egmond, M 2018, ' Spillage of bacterial products during colon surgery increases the risk of liver metastases development in a rat colon carcinoma model ', OncoImmunology, vol. 7, no. 9, pp. e1461302 . https://doi.org/10.1080/2162402X.2018.1461302
OncoImmunology, Vol 7, Iss 9 (2018)
OncoImmunology, 7(9). Landes Bioscience
OncoImmunology, Vol 7, Iss 9 (2018)
OncoImmunology, 7(9). Landes Bioscience
Surgical resection of the primary tumor provides the best chance of cure for patients with colorectal carcinoma (CRC). However, bacterial translocation during intestinal surgery has been correlated with poor long-term oncological outcome. Therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e9f278651ac431c9f1e76d30706059
https://research.vumc.nl/en/publications/adbde185-ecc8-4789-a297-4bc954f022a4
https://research.vumc.nl/en/publications/adbde185-ecc8-4789-a297-4bc954f022a4
Autor:
Niels Heemskerk, Jos van Rijssel, Vivian de Waard, Martin J. T. Kalsbeek, Jaap D. van Buul, Jeffrey Kroon
Publikováno v:
Molecular biology of the cell, 28(13), 1745-1753. American Society for Cell Biology
Molecular Biology of the Cell
Molecular Biology of the Cell
Long-term flow conditions promote endothelial cells to align in the direction of flow. The endothelial RhoGEF Trio keeps active Rac1 at the downstream side rather than exchanging GTP. Thus Trio acts as a scaffold protein to regulate endothelial cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481007f5209129aee11eecdc74c64c30
https://pure.amc.nl/en/publications/flowinduced-endothelial-cell-alignment-requires-the-rhogef-trio-as-a-scaffold-protein-to-polarize-active-rac1-distribution(88f930ae-9a36-4c5f-9a4c-fe705d5d6bf2).html
https://pure.amc.nl/en/publications/flowinduced-endothelial-cell-alignment-requires-the-rhogef-trio-as-a-scaffold-protein-to-polarize-active-rac1-distribution(88f930ae-9a36-4c5f-9a4c-fe705d5d6bf2).html