Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Niels Halama"'
Chemokines as Prognostic Factor in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
Autor:
Johanna Fellhofer-Hofer, Clemens Franz, Johannes A. Vey, Christoph Kahlert, Eva Kalkum, Arianeb Mehrabi, Niels Halama, Pascal Probst, Fee Klupp
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5374 (2024)
Chemokines orchestrate many aspects of tumorigenic processes such as angiogenesis, apoptosis and metastatic spread, and related receptors are expressed on tumor cells as well as on inflammatory cells (e.g., tumor-infiltrating T cells, TILs) in the tu
Externí odkaz:
https://doaj.org/article/3c878d6be08a4330958fa21b917df1d3
Autor:
Juri Fuchs, Anastasia Murtha-Lemekhova, Jan Pfeiffenberger, Alexander Fichtner, Patrick Günther, Niels Halama, Philipp Mayer, Daniel Hornuss, Rosa Klotz, Pascal Probst, Katrin Hoffmann, for the RELIVE Initiative
Publikováno v:
Systematic Reviews, Vol 11, Iss 1, Pp 1-3 (2022)
Abstract Background Rare liver lesions and diseases have seldomly aroused major interest of researchers. For most guidelines, presumably similar clinical conditions are pooled without detailed investigations of singularities that they present. Main t
Externí odkaz:
https://doaj.org/article/74e662c23f8b4079bf697d4ba0d74e45
Autor:
Rasha Hamid, Mustafa Alaziz, Amanpreet S. Mahal, Anthony W. Ashton, Niels Halama, Dirk Jaeger, Xuanmao Jiao, Richard G. Pestell
Publikováno v:
Cells, Vol 12, Iss 18, p 2237 (2023)
The G-protein-coupled receptor C-C chemokine receptor 5 (CCR5) functions as a co-receptor for the entry of HIV into immune cells. CCR5 binds promiscuously to a diverse array of ligands initiating cell signaling that includes guided migration. Althoug
Externí odkaz:
https://doaj.org/article/64e95e5aa2a144e990ce0386497385f1
Autor:
Christopher J. Neufeldt, Berati Cerikan, Mirko Cortese, Jamie Frankish, Ji-Young Lee, Agnieszka Plociennikowska, Florian Heigwer, Vibhu Prasad, Sebastian Joecks, Sandy S. Burkart, David Y. Zander, Baskaran Subramanian, Rayomand Gimi, Seetharamaiyer Padmanabhan, Radhakrishnan Iyer, Mathieu Gendarme, Bachir El Debs, Niels Halama, Uta Merle, Michael Boutros, Marco Binder, Ralf Bartenschlager
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Neufeldt et al. evaluate transcriptional and cytokine secretion profiles of cells and patient sera following SARS-CoV-2 infection and detect distinct upregulation of inflammatory cytokines. They also demonstrate that this upregulation is mediated by
Externí odkaz:
https://doaj.org/article/e74d2975b29b4848bc2c7e84d04fd670
Autor:
Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Thilo Hackert, Christoph Springfeld, Inka Zörnig, Dirk Jäger, Niels Halama
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Pancreatic ductal adenocarcinoma (PDA) is usually unresponsive to immunotherapeutic approaches. However, tertiary lymphoid structures (TLS) are associated with favorable patient outcomes in PDA. A better understanding of the B cell infiltrate and bio
Externí odkaz:
https://doaj.org/article/d020feab911c4d1fb6e309f2b562b91a
Autor:
Azaz Ahmed, Rosa Klotz, Sophia Köhler, Nathalia Giese, Thilo Hackert, Christoph Springfeld, Dirk Jäger, Niels Halama
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe peritumoral stroma is a hallmark of pancreatic ductal adenocarcinoma (PDA) with implications for disease development, progression and therapy resistance. We systematically investigated immune features of the stroma in PDA patients to id
Externí odkaz:
https://doaj.org/article/0d6322eca2fc4769a3335eabf7dd41e3
Autor:
Maria Xydia, Raheleh Rahbari, Eliana Ruggiero, Iain Macaulay, Maxime Tarabichi, Robert Lohmayer, Stefan Wilkening, Tillmann Michels, Daniel Brown, Sebastiaan Vanuytven, Svetlana Mastitskaya, Sean Laidlaw, Niels Grabe, Maria Pritsch, Raffaele Fronza, Klaus Hexel, Steffen Schmitt, Michael Müller-Steinhardt, Niels Halama, Christoph Domschke, Manfred Schmidt, Christof von Kalle, Florian Schütz, Thierry Voet, Philipp Beckhove
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their
Externí odkaz:
https://doaj.org/article/564548dac492461fa165fbbe611c1237
Autor:
Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Thilo Hackert, Christoph Springfeld, Dirk Jäger, Niels Halama
Publikováno v:
Cancers, Vol 15, Iss 6, p 1815 (2023)
Background: Mounting evidence suggests that sex plays a critical role in various aspects of cancer such as immune responses. However, a male bias exists in human and non-human studies including immunotherapy trials. The role of sex on immune response
Externí odkaz:
https://doaj.org/article/c24951d0aa6d424c9d89561d7585062f
Autor:
Maike Janssen, Ulrike Schäkel, Carine Djuka Fokou, Johannes Krisam, Jacek Stermann, Katharina Kriegsmann, Isabella Haberbosch, Jan Philipp Novotny, Stefan Weber, Maria Vehreschild, Martin Bornhäuser, Lars Bullinger, Michael Schmitt, Tobias Liebregts, Peter Dreger, Hanns-Martin Lorenz, Anna Plaszczyca, Ralf Bartenschlager, Barbara Müller, Hans-Georg Kräusslich, Niels Halama, Dirk Jäger, Richard F. Schlenk, Albrecht Leo, Stefan Meuer, Markus A. Weigand, Johann Motsch, Uta Merle, Claudia M. Denkinger, Carsten Müller-Tidow
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-4 (2020)
Abstract Objectives Primary objectives • To assess the time from randomisation until an improvement within 84 days defined as two points on a seven point ordinal scale or live discharge from the hospital in high-risk patients (group 1 to group 4) w
Externí odkaz:
https://doaj.org/article/2846c88e940f4f1aa7e46d73e536451d
Autor:
Dirk Jäger, Niels Halama, Jürgen Krauß, Nicolas Hohmann, Dirk Eulberg, Matthias Baumann, Anja Williams, Meggy Suarez-Carmona, Jutta Schreiber, Ulrike Pruefer, Anna Frömming, Diana Beyer, Jarf Ulf Jungelius, Aram Mangasarian
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/c21d6a5da77a4a5b90ee921e5f986569