Výsledky vyhledávání - "Niels Hagenaars"

The relationship between publication volume of biomedical research and burden of disease

Autor: Niels Hagenaars, Ingeborg Meijer, T M de Kruif, M. Levi, Ludo Waltman, A. Gupta, L A van de Laar

Publikováno v: None

Background One could hypothesize that the biomedical research agenda aligns with the (global) burden of disease, since it should aim to reduce illness and death. We investigated the relationship between publication volume and Research-dependent Fract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2159a421dd097dcd0da533d35cfd94cc
https://hdl.handle.net/1887/85312

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Improving the evaluation of worldwide biomedical research output: classification method and standardised bibliometric indicators by disease

Autor: Lissy van de Laar, Anshu Gupta, Thijs de Kruif, Ludo Waltman, Ingeborg Meijer, Niels Hagenaars

Publikováno v: BMJ open
BMJ open, 8(6), e020818
BMJ Open

Objective Since most biomedical research focuses on a specific disease, evaluation of research output requires disease-specific bibliometric indicators. Currently used methods are insufficient. The aim of this study is to develop a method that enable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26d097e77c2656f4b7addf061c7cde2
https://doi.org/10.1136/bmjopen-2017-020818

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A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine

Autor: Ethlinn V.B. van Gaal, Niels Hagenaars, Rolf J. Verheul, Wim E. Hennink, Thomas van Es, J.G.M. Heldens, Han van den Bosch, Bram Slütter, Pascal H.J.L.F. de Jong, Harrie L. Glansbeek, Enrico Mastrobattista, Ivo Que, Wim Jiskoot, Sven C. M. Bruijns

Publikováno v: Verheul, R J, Hagenaars, N, van Es, T, van Gaal, E V B, De Jong, P H J L, Bruijns, S C M, Mastrobattista, E, Slutter, B, Que, I, Heldens, J G M, van den Bosch, J F, Glansbeek, H L, Hennink, W E & Jiskoot, W 2012, ' A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine ', European Journal of Pharmaceutical Sciences, vol. 45, no. 4, pp. 467-474 . https://doi.org/10.1016/j.ejps.2011.10.001
European Journal of Pharmaceutical Sciences, 45(4), 467-474. Elsevier
European Journal of Pharmaceutical Sciences, 45(4), 467-474

Recently we reported that reacetylation of N,N,N-trimethyl chitosan (TMC) reduced the adjuvant effect of TMC in mice after intranasal (i.n.) administration of whole inactivated influenza virus (WIV) vaccine. The aim of the present study was to elucid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2805f81cd6a874130bfba468c4a6c5fa
https://doi.org/10.1016/j.ejps.2011.10.001

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Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine

Autor: Pascal H.J.L.F. de Jong, Niels Hagenaars, Enrico Mastrobattista, J.G.M. Heldens, Harrie L. Glansbeek, Rolf J. Verheul, Imke Mooren, Wim E. Hennink, Han van den Bosch, Wim Jiskoot

Publikováno v: Journal of Controlled Release. 140:126-133

The aim of this study was to assess the influence of structural properties of N,N,N-trimethyl chitosan (TMC) on its adjuvanticity. Therefore, TMCs with varying degrees of quaternization (DQ, 22-86%), O-methylation (DOM, 0-76%) and acetylation (DAc 9-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12644b4f4b1c4cfe3a1b707f2346acb0
https://doi.org/10.1016/j.jconrel.2009.08.018

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Head-to-head comparison of four nonadjuvanted inactivated cell culture-derived influenza vaccines: Effect of composition, spatial organization and immunization route on the immunogenicity in a murine challenge model

Autor: Niels Hagenaars, Herman Vromans, Enrico Mastrobattista, Virgil E.J.C. Schijns, Harrie L. Glansbeek, Wim Jiskoot, Han van den Bosch, Didier Betbeder, J.G.M. Heldens

Publikováno v: Vaccine. 26:6555-6563

In order to study the influence of antigen composition, spatial organization of antigen and the route of administration, four cell culture-derived, inactivated, nonadjuvanted influenza vaccine formulations, i.e. whole inactivated virus (WIV), split,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79be228432d7c7b0ee4f4fa1e5ac3d31
https://doi.org/10.1016/j.vaccine.2008.09.057

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Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine

Autor: Niels Hagenaars, Clemens W.G.M. Löwik, Jacco G. M. Heldens, Harrie L. Glansbeek, Han van den Bosch, Wim Jiskoot, Bram Slütter, Eric L. Kaijzel, Rob Nieuwland, Ivo Que, Enrico Mastrobattista, Pascal H.J.L.F. de Jong, Marta Mania

Publikováno v: Journal of Controlled Release, 144(1), 17-24
Journal of Controlled Release, 144(1), 17-24. Elsevier
Hagenaars, N, Mania, M, De Jong, P, Que, I, Nieuwland, R, Slütter, B, Glansbeek, H, Heldens, J, van den Bosch, H, Löwik, C, Kaijzel, E L, Mastrobattista, E & Jiskoot, W 2010, ' Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine ', Journal of Controlled Release, vol. 144, no. 1, pp. 17-24 . https://doi.org/10.1016/j.jconrel.2010.01.027

The nose is a promising immunization site and intranasal (in.) vaccination studies with whole inactivated influenza virus (WIV) adjuvanted with N,N,N-trimethylchitosan (TMC-WIV) have shown promising results. In this study, the influence of TMC on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7ec3d29fcc22c71e383d07c8b31d70
https://pubmed.ncbi.nlm.nih.gov/20100528

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Physicochemical and immunological characterization of N,N,N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration

Autor: Enrico Mastrobattista, Niels Hagenaars, Rolf J. Verheul, Wim Jiskoot, Han van den Bosch, J.G.M. Heldens, Imke Mooren, Harrie L. Glansbeek

Publikováno v: Pharmaceutical research. 26(6)

The purpose of this study was the development and physicochemical and immunological characterization of intranasal (i.n.) vaccine formulations of whole inactivated influenza virus (WIV) coated with N,N,N-trimethyl chitosan (TMC).Synthesized TMCs with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a310de2cc702f3ef26ebe5dde16783
https://pubmed.ncbi.nlm.nih.gov/19224344

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Rational design of nasal vaccines

Autor: Niels Hagenaars, Bram Slütter, Wim Jiskoot

Nasal vaccination is a promising alternative to classical parental vaccination, as it is non-invasive and, in principle, capable of eliciting strong systemic and local immune responses. However, the protective efficacy of nasally administered antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd5b4fd2162a65bce0799534113fa8a
https://dspace.library.uu.nl/handle/1874/40363

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Akademický článek

Physicochemical and Immunological Characterization of N,N,N-Trimethyl Chitosan-Coated Whole Inactivated Influenza Virus Vaccine for Intranasal Administration.

Autor: Niels Hagenaars, Enrico Mastrobattista, Rolf Verheul, Imke Mooren, Harrie Glansbeek, Jacco Heldens, Han van den Bosch, Wim Jiskoot

Publikováno v: Pharmaceutical Research; Jun2009, Vol. 26 Issue 6, p1353-1364, 12p

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