Výsledky vyhledávání - "Niels H. Skotte"

Akademický článek

Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington’s disease

Autor: Meeli Mullari, Nicolas Fossat, Niels H. Skotte, Andrea Asenjo-Martinez, David T. Humphreys, Jens Bukh, Agnete Kirkeby, Troels K. H. Scheel, Michael L. Nielsen

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract RNA-binding proteins (RBPs) are key players regulating RNA processing and are associated with disorders ranging from cancer to neurodegeneration. Here, we present a proteomics workflow for large-scale identification of RBPs and their RNA-bin

Externí odkaz: https://doaj.org/article/af7bee72a0c145a5ad5d646db7ed76f4

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Akademický článek

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

Autor: Jens V. Andersen, Niels H. Skotte, Sofie K. Christensen, Filip S. Polli, Mohammad Shabani, Kia H. Markussen, Henriette Haukedal, Emil W. Westi, Marta Diaz-delCastillo, Ramon C. Sun, Kristi A. Kohlmeier, Arne Schousboe, Matthew S. Gentry, Heikki Tanila, Kristine K. Freude, Blanca I. Aldana, Matthias Mann, Helle S. Waagepetersen

Publikováno v: Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)

Abstract Alzheimer’s disease (AD) is an unremitting neurodegenerative disorder characterized by cerebral amyloid-β (Aβ) accumulation and gradual decline in cognitive function. Changes in brain energy metabolism arise in the preclinical phase of A

Externí odkaz: https://doaj.org/article/65bc66f8ef10424aabe726a04584a21a

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Akademický článek

Site-specific characterization of endogenous SUMOylation across species and organs

Autor: Ivo A. Hendriks, David Lyon, Dan Su, Niels H. Skotte, Jeremy A. Daniel, Lars J. Jensen, Michael L. Nielsen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Proteomics is a powerful method to study protein SUMOylation, but system-wide insights into endogenous SUMO2/3 modification events are still sparse. Here, the authors develop a more sensitive SUMO proteomics approach, providing detailed maps of endog

Externí odkaz: https://doaj.org/article/f1a95d5fa715451a8a9764153f666d48

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Akademický článek

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

Autor: Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels H. Skotte, Yen T. N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi, Michael R. Hayden

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)

Abstract Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo load

Externí odkaz: https://doaj.org/article/3098d7176f61480fbe25947e9399afed

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Akademický článek

Reduced gluconeogenesis and lactate clearance in Huntington's disease

Autor: Knud Josefsen, Signe M.B. Nielsen, André Campos, Thomas Seifert, Lis Hasholt, Jørgen E. Nielsen, Anne Nørremølle, Niels H. Skotte, Niels H. Secher, Bjørn Quistorff

Publikováno v: Neurobiology of Disease, Vol 40, Iss 3, Pp 656-662 (2010)

We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control subjects, but no peak was seen in any

Externí odkaz: https://doaj.org/article/282c9138827345a78db41605660c1746

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Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex

Autor: Jens V. Andersen, Emil W. Westi, Nane Griem‐Krey, Niels H. Skotte, Arne Schousboe, Blanca I. Aldana, Petrine Wellendorph

Publikováno v: Journal of Neurochemistry.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8238457255184bba096264fd3613efc
https://doi.org/10.1111/jnc.15814

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D13 Saliva biomarker discovery in Huntington’s disease

Autor: Filippa L Qvist, Marie NN Hellem, Jørgen E Nielsen, Matthias Mann, Niels H Skotte

Publikováno v: D: Wet biomarkers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7af0989003874dee23726c29162d5dd
https://doi.org/10.1136/jnnp-2022-ehdn.69

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Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

Autor: Kia H. Markussen, Heikki Tanila, Henriette Haukedal, Matthew S. Gentry, Kristi A. Kohlmeier, Arne Schousboe, Kristine K. Freude, Ramon C. Sun, Matthias Mann, Filip S. Polli, Niels H. Skotte, Sofie K. Christensen, Marta Diaz-delCastillo, Jens V. Andersen, Blanca I. Aldana, Emil W. Westi, Helle S. Waagepetersen, Mohammad Shabani

Publikováno v: Andersen, J V, Skotte, N H, Christensen, S K, Polli, F S, Shabani, M, Markussen, K H, Haukedal, H, Westi, E W, Diaz-delCastillo, M, Sun, R C, Kohlmeier, K A, Schousboe, A, Gentry, M S, Tanila, H, Freude, K K, Aldana, B I, Mann, M & Waagepetersen, H S 2021, ' Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease ', Cell Death & Disease, vol. 12, no. 11, 954 . https://doi.org/10.1038/s41419-021-04237-y
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease

Alzheimer’s disease (AD) is an unremitting neurodegenerative disorder characterized by cerebral amyloid-β (Aβ) accumulation and gradual decline in cognitive function. Changes in brain energy metabolism arise in the preclinical phase of AD, sugges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccf3de41e3c461ced3ba3e98e714ce1
https://doi.org/10.1038/s41419-021-04237-y

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Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in fragile X syndrome

Autor: Qiyu Chen, Marta Garcia-Miralles, Carola I. Radulescu, Bernice Sim, Xin Yi Yeo, Herty Liany, Georgia Chaldaiopoulou, Matthias Mann, Maija L. Castrén, Mahmoud A. Pouladi, Sangyong Jung, Srikanth Nama, Prabha Sampath, Han-Gyu Bae, Niels H. Skotte, Kagistia Hana Utami, Ana R. Colaço, Ulla-Kaisa Peteri, Nur Amirah Binte Mohammad Yusof

Background Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by epigenetic silencing of FMR1 and loss of FMRP expression. Efforts to understand the molecular underpinnings of the disease have been largely performed in rodent or nonisog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90df106193303f98a564f5e2a2f82817
http://hdl.handle.net/10138/333443

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Palmitoylation of caspase-6 by HIP14 regulates its activation

Autor: Xiaofan Qiu, Dagmar E. Ehrnhoefer, Roshni R. Singaraja, Shaun S. Sanders, Kuljeet Vaid, Michael R. Hayden, Niels H. Skotte, Srinivasaragavan Kannan, Chandra S. Verma

Publikováno v: Cell Death & Differentiation. 24:433-444

Caspase-6 (CASP6) has an important role in axonal degeneration during neuronal apoptosis and in the neurodegenerative diseases Alzheimer and Huntington disease. Decreasing CASP6 activity may help to restore neuronal function in these and other diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade913fcdcd397c3d1e66c87646fa934
https://doi.org/10.1038/cdd.2016.139

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