Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Niels H. Gehring"'
Autor:
Volker Boehm, Sabrina Kueckelmann, Jennifer V. Gerbracht, Sebastian Kallabis, Thiago Britto-Borges, Janine Altmüller, Marcus Krüger, Christoph Dieterich, Niels H. Gehring
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintai
Externí odkaz:
https://doaj.org/article/9c2915beac40413f8c56308a467df541
Autor:
Annie M. Sriramachandran, Katrin Meyer-Teschendorf, Stefan Pabst, Helle D. Ulrich, Niels H. Gehring, Kay Hofmann, Gerrit J. K. Praefcke, R. Jürgen Dohmen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targ
Externí odkaz:
https://doaj.org/article/d0762ab2824541ce8ce0b7085be1b113
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Degradation of messenger RNA is a key regulatory step in controlling eukaryotic gene expression. Here the authors present xrFrag, a molecular tool to interrogate the extent and directionality of mRNA turnover by the detection of stabilized decay inte
Externí odkaz:
https://doaj.org/article/4df3f5547cd041fa9a60258e7949e822
Autor:
Lena P. Schlautmann, Niels H. Gehring
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 866 (2020)
The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP) component that is assembled during splicing and binds to mRNAs upstream of exon-exon junctions. EJCs accompany the mRNA during its entire life in the nucleus and the cy
Externí odkaz:
https://doaj.org/article/aa019f5a36b4458ab676e9958ad64969
Autor:
Lara Ajamian, Karen Abel, Shringar Rao, Kishanda Vyboh, Francisco García-de-Gracia, Ricardo Soto-Rifo, Andreas E. Kulozik, Niels H. Gehring, Andrew J. Mouland
Publikováno v:
Biomolecules, Vol 5, Iss 4, Pp 2808-2839 (2015)
Unspliced, genomic HIV-1 RNA (vRNA) is a component of several ribonucleoprotein complexes (RNP) during the viral replication cycle. In earlier work, we demonstrated that the host upframeshift protein 1 (UPF1), a key factor in nonsense-mediated mRNA d
Externí odkaz:
https://doaj.org/article/c3766bdb1e4348ddbe1c4472c2fd0475
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 555-568 (2014)
Nonsense-mediated mRNA decay (NMD) degrades different classes of mRNAs, including transcripts with premature termination codons (PTCs). The NMD factor SMG6 initiates degradation of substrate mRNAs by endonucleolytic cleavage. Here, we aim to delineat
Externí odkaz:
https://doaj.org/article/71be9370767a42578f089d78237b8eb8
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 454-461 (2012)
The exon junction complex (EJC) is a key regulator of posttranscriptional mRNA fate and binds to mRNA during splicing. Although the composition of EJCs is well understood, the mechanism mediating splicing-dependent EJC assembly and the factor(s) recr
Externí odkaz:
https://doaj.org/article/f3c5c5cbcc204148b28e0de7dced2c03
A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis
Autor:
Esra Peker, Konstantin Weiss, Jiyao Song, Christine Zarges, Sarah Gerlich, Volker Boehm, Aleksandra Trifunovic, Thomas Langer, Niels H. Gehring, Thomas Becker, Jan Riemer
Publikováno v:
Journal of Cell Biology. 222
Mitochondria critically rely on protein import and its tight regulation. Here, we found that the complex I assembly factor NDUFAF8 follows a two-step import pathway linking IMS and matrix import systems. A weak targeting sequence drives TIM23-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1adf7919867f5b307fec5aadbbbe7784
https://doi.org/10.1083/jcb.202210019
https://doi.org/10.1083/jcb.202210019
Autor:
Ann-Katrin Claudius, Steffen Erkelenz, Juliane Mundorf, Niels H. Gehring, Dimitrije Stanković, Volker Boehm, Mirka Uhlirova, Tina Bresser
Publikováno v:
Nucleic Acids Research
Pre-mRNA splicing catalyzed by the spliceosome represents a critical step in the regulation of gene expression contributing to transcriptome and proteome diversity. The spliceosome consists of five small nuclear ribonucleoprotein particles (snRNPs),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10970a7d42a53256c2935550f320f34
https://doi.org/10.1093/nar/gkaa1274
https://doi.org/10.1093/nar/gkaa1274
CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex
Autor:
Niels H. Gehring, Janica L Wiederstein, Dominik Aschemeier, Jennifer V. Gerbracht, Simona Ciriello, Janine Altmüller, Christian K. Frese, Thiago Britto-Borges, Christoph Dieterich, Volker Boehm, Marcus Krueger, Sebastian Kallabis
Publikováno v:
Nucleic Acids Research
The exon junction complex (EJC) is an essential constituent and regulator of spliced messenger ribonucleoprotein particles (mRNPs) in metazoans. As a core component of the EJC, CASC3 was described to be pivotal for EJC-dependent nuclear and cytoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93c9065d3ff03c8fc471d610d3a3eff
https://doi.org/10.1093/nar/gkaa564
https://doi.org/10.1093/nar/gkaa564