Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Niels H. Buus"'
Publikováno v:
Case Reports in Critical Care, Vol 2018 (2018)
Metformin poisoning is a life-threatening condition with a high mortality rate. We present a patient case of metformin poisoning following intake of 80 g metformin resulting in severe lactate acidosis with a nadir pH of 6.73 and circulatory collapse,
Externí odkaz:
https://doaj.org/article/77cd0966e5a146078e96437427e59033
Autor:
Ulla Kampmann, Ole N. Mathiassen, Kent L. Christensen, Niels H. Buus, Mette Bjerre, Henrik Vase, Niels Møller, Anne Kaltoft, Per L. Poulsen
Publikováno v:
Journal of Diabetes Research, Vol 2017 (2017)
Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance. Afferent signaling from the kidneys elevates the central sympathetic drive. We investigated the effect of catheter-based renal sympathetic denerva
Externí odkaz:
https://doaj.org/article/48b42b5fb1a74b568954bb0707e472cf
Autor:
Christian D. Peters, Ole N. Mathiasen, Henrik Vase, Jesper Bech, Kent L. Christensen, Anne P. Schroeder, Ole Lederballe, Hans Rickers, Ulla Kampmann, Per L. Poulsen, Sten Langfeldt, Gratien Andersen, Klavs W. Hansen, Hans E. Bøtker, Morten Engholm, Jannik B. Bertelsen, Jens F. Lassen, Erling B. Pedersen, Anne Kaltoft, Niels H. Buus
Publikováno v:
Artery Research, Vol 16 (2016)
Background: A recent sham-controlled trial (ReSET) showed no sustained effect of renal denervation (RDN) on 24-hour ambulatory blood pressure (24hA-BP) measurements in patients with treatment resistant hypertension.1 The aim of this substudy was to i
Externí odkaz:
https://doaj.org/article/fb954618a46846a1a16558705d199897
Autor:
Morten Engholm, Jannik B. Bertelsen, Ole N. Mathiassen, Henrik Vase, Jesper N. Bech, Anne P. Schroeder, Ole Lederballe, Hans Rickers, Christian D. Peters, Ulla Kampmannf, Per L. Poulsen, Sten Langfeldt, Gratien Andersen, Klavs W. Hansen, Erling B. Pedersen, Jens F. Lassen, Hans E. Boetker, Niels H. Buus, Anne Kaltoft, Kent L. Christensen
Publikováno v:
Artery Research, Vol 16 (2016)
Externí odkaz:
https://doaj.org/article/d3dae40890c54aef98c85b4ba5703f17
Autor:
Rasmus K. Carlsen, Christian D. Peters, Esben Laugesen, Simon Winther, Dinah S. Khatir, Hans E. Boetker, Morten Boettcher, Per Ivarsen, My Svensson, Niels H. Buus
Publikováno v:
Artery Research, Vol 16 (2016)
Background: We recently reported that central blood pressure (BP) obtained non-invasively in chronic kidney disease (CKD) patients significantly underestimated the central BP with decreasing eGFR in comparison with invasively measured true central BP
Externí odkaz:
https://doaj.org/article/8db3b27f650c48489eeb4fbf7df911e2
Autor:
Niels H. Buus, Camilla Asferg, Jørgen Jeppesen, Bahareh Abdolalizadeh, Rasmus Dreier, Julie Lyng Forman, Lisbet Rosenkrantz Hölmich, Martin Egfjord, Majid Sheykhzade, Ulrik B. Andersen
Publikováno v:
Nephrology Dialysis Transplantation. 36:1282-1291
Background Increased potassium intake lowers blood pressure (BP) in hypertensive patients. The underlying mechanism is not fully understood but must be complex because increased potassium intake elevates circulating concentrations of the BP-raising h
Autor:
Michael Pedersen, Kent L. Christensen, Dinah S. Khatir, Bente Jespersen, Per Ivarsen, Niels H. Buus
Publikováno v:
Khatir, D S, Pedersen, M, Ivarsen, P, Christensen, K L, Jespersen, B & Buus, N H 2019, ' Effects of additional vasodilatory or nonvasodilatory treatment on renal function, vascular resistance and oxygenation in chronic kidney disease : a randomized clinical trial ', Journal of Hypertension, vol. 37, no. 1, pp. 116-124 . https://doi.org/10.1097/HJH.0000000000001835
Khatir, D S, Pedersen, M, Ivarsen, P, Christensen, K L, Jespersen, B & Buus, N H 2019, ' Effects of additional vasodilatory or nonvasodilatory treatment on renal function, vascular resistance and oxygenation in chronic kidney disease : A randomized clinical trial ', Journal of Hypertension, vol. 37, no. 1, pp. 116-124 . https://doi.org/10.1097/HJH.0000000000001835
Khatir, D S, Pedersen, M, Ivarsen, P, Christensen, K L, Jespersen, B & Buus, N H 2019, ' Effects of additional vasodilatory or nonvasodilatory treatment on renal function, vascular resistance and oxygenation in chronic kidney disease : A randomized clinical trial ', Journal of Hypertension, vol. 37, no. 1, pp. 116-124 . https://doi.org/10.1097/HJH.0000000000001835
Aim:Progression of chronic kidney disease (CKD) may be accelerated by tissue hypoxia due to impaired blood supply. This could be induced by small artery narrowing resulting in abnormally high intrarenal vascular resistance (RVR). We investigated whet
Autor:
Luis Rivera, Judit Prat-Duran, Ulf Simonsen, Vladimir V. Matchkov, Estéfano Pinilla, Simon Comerma-Steffensen, Niels H. Buus
Publikováno v:
Pinilla, E, Comerma Steffensen, S G, Prat Duran, J, Rivera, L, Matchkov, V, Buus, N H & Simonsen, U 2021, ' Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries ', Hypertension, vol. 77, no. 1, pp. 216-227 . https://doi.org/10.1161/HYPERTENSIONAHA.120.15352
Transglutaminase 2 (TG2) is an enzyme which in the open conformation exerts transamidase activity, leading to protein cross-linking and fibrosis. In the closed conformation, TG2 participates in transmembrane signaling as a G protein. The unspecific t
Publikováno v:
Prat-Duran, J, Pinilla, E, Nørregaard, R, Simonsen, U & Buus, N H 2021, ' Transglutaminase 2 as a novel target in chronic kidney disease-Methods, mechanisms and pharmacological inhibition ', Pharmacology & Therapeutics, vol. 222, 107787 . https://doi.org/10.1016/j.pharmthera.2020.107787
Chronic kidney disease (CKD) is a global health problem with a prevalence of 10-15%. Progressive fibrosis of the renal tissue is a main feature of CKD, but current treatment strategies are relatively unspecific and delay, but do not prevent, CKD. Exp
Publikováno v:
Wehland, M, Simonsen, U, Buus, N H, Krüger, M & Grimm, D 2020, ' An evaluation of the fixed-dose combination sacubitril/valsartan for the treatment of arterial hypertension ', Expert Opinion on Pharmacotherapy, vol. 21, no. 10, pp. 1133-1143 . https://doi.org/10.1080/14656566.2020.1735356
Introduction: Essential hypertension is a significant risk factor for cardiovascular disease, renal disease, and mortality with increasing prevalence. Despite the availability of various antihypertensive agents, hypertension is still poorly controlle