Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Niels Grabe"'
Autor:
Felipe Miranda Ruiz, Bernd Lahrmann, Liam Bartels, Alexandra Krauthoff, Andreas Keil, Steffen Härtel, Amy S. Tao, Philipp Ströbel, Megan A. Clarke, Nicolas Wentzensen, Niels Grabe
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundIn digital pathology, image properties such as color, brightness, contrast and blurriness may vary based on the scanner and sample preparation. Convolutional Neural Networks (CNNs) are sensitive to these variations and may underperform on i
Externí odkaz:
https://doaj.org/article/ca9a4f8b047a41a79bf6def099fe001c
Autor:
Marcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M. E. Weiler, Carsten Sticht, Carolina De La Torre, Melina Rausch, Thomas Albrecht, Niels Grabe, Lea Duwe, Jesper B. Andersen, Bruno C. Köhler, Christoph Springfeld, Arianeb Mehrabi, Yakup Kulu, Peter Schirmacher, Stephanie Roessler, Benjamin Goeppert, Kai Breuhahn
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Activation of the oncogene yes-associated protein (YAP) is frequently detected in intrahepatic cholangiocarcinoma (iCCA); however, the expression pattern and the functional impact of its paralogue WW domain-containing transcriptio
Externí odkaz:
https://doaj.org/article/dffad727f8a042bbb433f912e31ec171
Autor:
Maria Xydia, Raheleh Rahbari, Eliana Ruggiero, Iain Macaulay, Maxime Tarabichi, Robert Lohmayer, Stefan Wilkening, Tillmann Michels, Daniel Brown, Sebastiaan Vanuytven, Svetlana Mastitskaya, Sean Laidlaw, Niels Grabe, Maria Pritsch, Raffaele Fronza, Klaus Hexel, Steffen Schmitt, Michael Müller-Steinhardt, Niels Halama, Christoph Domschke, Manfred Schmidt, Christof von Kalle, Florian Schütz, Thierry Voet, Philipp Beckhove
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their
Externí odkaz:
https://doaj.org/article/564548dac492461fa165fbbe611c1237
Autor:
Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, Patrick Metzger, Fengshen Kuo, Désirée Schönenberger, Mojca Adlesic, Asin Peighambari, Philipp Seidel, Chia-yi Chen, Miguel Consenza-Contreras, Andreas Jud, Bernd Lahrmann, Niels Grabe, Danijela Heide, Franziska M. Uhl, Timothy A. Chan, Justus Duyster, Robert Zeiser, Christoph Schell, Mathias Heikenwalder, Oliver Schilling, A. Ari Hakimi, Melanie Boerries, Ian J. Frew
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that
Externí odkaz:
https://doaj.org/article/c9223cd55c18449db9d005eb65c4887e
Autor:
Rouven Hoefflin, Sabine Harlander, Behnaz A. Abhari, Asin Peighambari, Mojca Adlesic, Philipp Seidel, Kyra Zodel, Stefan Haug, Burulca Göcmen, Yong Li, Bernd Lahrmann, Niels Grabe, Danijela Heide, Melanie Boerries, Anna Köttgen, Mathias Heikenwalder, Ian J. Frew
Publikováno v:
Cancers, Vol 13, Iss 19, p 4801 (2021)
Specific inhibitors of HIF-2α have recently been approved for the treatment of ccRCC in VHL disease patients and have shown encouraging results in clinical trials for metastatic sporadic ccRCC. However, not all patients respond to therapy and pre-cl
Externí odkaz:
https://doaj.org/article/b04abf253c0543498f3089d4b6881e47
Autor:
Nele Kreycy, Christiane Gotzian, Thomas Fleming, Christa Flechtenmacher, Niels Grabe, Peter Plinkert, Jochen Hess, Karim Zaoui
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-9 (2017)
Abstract Background Glyoxalase 1 is a key enzyme in the detoxification of reactive metabolites such as methylglyoxal and induced Glyoxalase 1 expression has been demonstrated for several human malignancies. However, the regulation and clinical releva
Externí odkaz:
https://doaj.org/article/3951c6c96c7b48cd9d91e9ee0143cdef
Publikováno v:
PeerJ, Vol 7, p e6335 (2019)
Recent years have seen a growing awareness of the role the immune system plays in successful cancer treatment, especially in novel therapies like immunotherapy. The characterization of the immunological composition of tumors and their micro-environme
Externí odkaz:
https://doaj.org/article/ba9a9355e95e4b6ebe9cbfbb801f66b0
Autor:
Erika Tsingos, Burkhard Höckendorf, Thomas Sütterlin, Stephan Kirchmaier, Niels Grabe, Lazaro Centanin, Joachim Wittbrodt
Publikováno v:
eLife, Vol 8 (2019)
Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka (Oryzias latipes) coordinate their growth rates. NR ce
Externí odkaz:
https://doaj.org/article/821cc2715f6040a9a5ccf56d8de0343c
Autor:
Mihály Ruppert, Sevil Korkmaz-Icöz, Shiliang Li, Paige Brlecic, Balázs Tamás Németh, Attila Oláh, Eszter M. Horváth, Gábor Veres, Sven Pleger, Niels Grabe, Béla Merkely, Matthias Karck, Tamás Radovits, Gábor Szabó
Publikováno v:
Frontiers in Physiology, Vol 9 (2019)
Background: Pressure unloading induces the regression of left ventricular myocardial hypertrophy (LVH). Recent findings indicate that pharmacological activation of the soluble guanylate cyclase (sGC) – cyclic guanosine monophosphate (cGMP) pathway
Externí odkaz:
https://doaj.org/article/cf189accbc1641079b76ccfe12690df7
Autor:
Rouven Hoefflin, Bernd Lahrmann, Gregor Warsow, Daniel Hübschmann, Cathleen Spath, Britta Walter, Xin Chen, Luisa Hofer, Stephan Macher-Goeppinger, Yanis Tolstov, Nina Korzeniewski, Anette Duensing, Carsten Grüllich, Dirk Jäger, Sven Perner, Gita Schönberg, Joanne Nyarangi-Dix, Sanjay Isaac, Gencay Hatiboglu, Dogu Teber, Boris Hadaschik, Sascha Pahernik, Wilfried Roth, Roland Eils, Matthias Schlesner, Holger Sültmann, Markus Hohenfellner, Niels Grabe, Stefan Duensing
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour doe
Externí odkaz:
https://doaj.org/article/6b8b3ea588cd4746baa64e76cce15f72