Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Niels Erik Olesen"'
Autor:
Korbinian Löbmann, Katharina Brede, Niels Erik Olesen, Matthias Manne Knopp, Nele-Johanna Hempel, Natalja Genina
Publikováno v:
International Journal of Pharmaceutics. 544:153-157
The aim of this study was to introduce a fast and reliable differential scanning calorimetry (DSC)-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica (MS). The proposed method is
Publikováno v:
International Journal of Pharmaceutics. 540:98-105
The aim of the present study was to compare two DSC-based methods to predict drug-polymer solubility (melting point depression method and recrystallization method) and propose a guideline for selecting the most suitable method based on physicochemica
Autor:
Søren V. Søgaard, Jukka Rantanen, Morten Allesø, Joergen Garnaes, Niels Erik Olesen, Cosima Hirschberg, Morten Hannibal Madsen
Publikováno v:
Powder Technology. 321:523-532
This study presents an evaluation of the predicted and experimentally observed flow behavior, i.e., flow pattern and critical outlet diameter, in a tablet press hopper. Three grades of a commonly used pharmaceutical additive, microcrystalline cellulo
Autor:
Peter Langguth, René Holm, Ilona Porsch, Matthias Manne Knopp, Natasha Gannon, Thomas Rades, Malte Bille Rask, Niels Erik Olesen
Publikováno v:
Journal of Pharmaceutical Sciences. 105:2621-2624
The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work inve
Publikováno v:
Journal of Pharmaceutical Sciences. 105:2640-2647
The dosing of drugs in an aqueous cyclodextrin formulation requires sufficient amount of cyclodextrins to fully solubilize the drug, as described by Stella's cyclodextrin utility number (UCD). However, this framework does not take biopharmaceutical e
Autor:
René Holm, Niels Erik Olesen, Huiling Mu, Signe Dalgaard Alexandersen, Birgitte N. Dahlgaard, Peter Westh
Publikováno v:
European Journal of Pharmaceutical Sciences. 87:22-29
Preservatives are inactivated when added to conserve aqueous cyclodextrin (CD) formulations due to complex formation between CDs and the preservative. To maintain the desired conservation effect the preservative needs to be added in apparent surplus
Publikováno v:
European Journal of Pharmaceutical Sciences. 85:10-17
In this study, the influence of copolymer composition on drug-polymer solubility was investigated. The solubility of the model drug celecoxib (CCX) in various polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer compositions (70/30, 60/40, 50/50 and
Publikováno v:
Journal of Pharmaceutical Sciences. 105:362-367
In this study, a method proposed to predict drug-polymer miscibility from differential scanning calorimetry measurements was subjected to statistical analysis. The method is relatively fast and inexpensive and has gained popularity as a result of the
Publikováno v:
Journal of Pharmaceutical Sciences. 104:2905-2912
In this study, the influence of polymer molecular weight on drug–polymer solubility was investigated using binary systems containing indomethacin (IMC) and polyvinylpyrrolidone (PVP) of different molecular weights. The experimental solubility in PV
Publikováno v:
Journal of Colloid and Interface Science. 453:79-89
The aggregation number (n), thermodynamic potentials (ΔG, ΔH, ΔS) and critical micelle concentration (CMC) for 6 natural bile salts were determined on the basis of both original and previously published isothermal titration calorimetry (ITC) data.