Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Niels Eckstein"'
Publikováno v:
Metabolites, Vol 14, Iss 6, p 342 (2024)
With a rising demand of cocaine over the last years, it is likely that unregulated new psychoactive substances with similar effects such as indatraline ((1R,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine) and troparil (Methyl (1R,2S
Externí odkaz:
https://doaj.org/article/df3464c68c3f4f8aaa956f73b0273292
Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
Autor:
Bodo Haas, Veronika Klinger, Christina Keksel, Verena Bonigut, Daniela Kiefer, Julia Caspers, Julia Walther, Maria Wos-Maganga, Sandra Weickhardt, Gabriele Röhn, Marco Timmer, Roland Frötschl, Niels Eckstein
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Intrinsic chemoresistance of glioblastoma (GBM) is frequently owed to activation of the PI3K and MEK/ERK pathways. These signaling cascades are tightly interconnected however the quantitative contribution of both to intrinsic resi
Externí odkaz:
https://doaj.org/article/cbc74fa257cc4e36b6334340db9acf0c
Publikováno v:
Metabolites, Vol 11, Iss 1, p 3 (2020)
Synthetic cathinones belong to the most often seized new psychoactive substances on an international level. This study investigated the toxicometabolomics, particularly the in vitro metabolism of 2-(methylamino)-1-(4-methylphenyl)-1-pentanone (4-MPD)
Externí odkaz:
https://doaj.org/article/a7397497257542ecb0e69dbe62a93daa
Autor:
Hans-Dieter Royer, Carsten Denkert, Brigitte Royer-Pokora, Manfred Dietel, Manfred Beier, Jan Budczies, Matthias U. Kassack, Alexandra Hamacher, Inge Napierski, Sybille Wolf-Kümmeth, Georg von Jonquières, Anne Pölitz, Barbara Hildebrandt, Kati Servan, Niels Eckstein
Platinum plays a central role in the therapy of ovarian cancer, and the emergence of platinum resistance is a major obstacle for clinical management of the disease. We treated A2780 ovarian cancer cells by weekly cycles of cisplatin over a period of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd194349894177406e13d95c1d31a870
https://doi.org/10.1158/0008-5472.c.6499425.v1
https://doi.org/10.1158/0008-5472.c.6499425.v1
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Journal of cancer research and clinical oncology, 147:779-792
Journal of cancer research and clinical oncology, 147:779-792
Purpose d,l-methadone (MET), an analgesic drug used for pain treatment and opiate addiction, has achieved attention from oncologists and social media as possible chemoensitizing agent in cancer therapy, notably brain cancer (glioblastoma multiforme,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a74260397a4821bc4f74801c46ebcf
http://europepmc.org/articles/PMC7872955
http://europepmc.org/articles/PMC7872955
Autor:
Christina Felske, Lea Wagmann, Sascha K. Manier, Matthias J Richter, Niels Eckstein, Tanja M. Gampfer, Markus R. Meyer
Publikováno v:
Journal of Analytical Toxicology. 45:1014-1027
Flubromazolam is widely known as highly potent designer benzodiazepine (DBZD). Recently, the two flubromazolam-derived new psychoactive substances (NPS) clobromazolam and bromazolam appeared on the drugs of abuse market. Since no information concerni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5290fb7415fb2a8e7cd3e02b3a2d52b
https://doi.org/10.1093/jat/bkaa161
https://doi.org/10.1093/jat/bkaa161
Publikováno v:
Journal of Public Health. 30:409-415
In a global comparison, in 2006 Germany was the first in the world to switch naratriptan to an OTC medication but since then only almotriptan has been switched. Therefore, Germany has fallen behind recently because of the failure to carry out further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33f193a02782649d9e67ea85b9835f7c
https://doi.org/10.1007/s10389-020-01310-2
https://doi.org/10.1007/s10389-020-01310-2
Publikováno v:
Journal of Public Health. 29:9-17
The consent of community pharmacists is an important factor for the successful implementation of Rx-to-OTC switches but is not part of the official reclassification procedure in Germany. The aim was to identify potential switch candidates and indicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e8f15711aa5280f67086682f11cfe27
https://doi.org/10.1007/s10389-019-01101-4
https://doi.org/10.1007/s10389-019-01101-4
Background D,L-methadone (MET), an analgesic drug used for pain treatment and opiate addiction has achieved attention from oncologist and social media as possible chemosensitizing agent in glioblastoma multiforme (GBM) treatment. MET has been reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::965d7804289a179b791a47bc3b57e615
https://doi.org/10.21203/rs.3.rs-62227/v1
https://doi.org/10.21203/rs.3.rs-62227/v1