Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Niels D Prins"'
Autor:
Jolene F Leijenaar, Silvia Ingala, Carole H Sudre, Henk-Jan MM Mutsaerts, Anna E. Leeuwis, Wiesje M van der Flier, Philip Scheltens, Henry C Weinstein, Frederik Barkhof, Joop van Gerven, Geert Jan Groeneveld, Niels D Prins
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 3, Iss , Pp 100128- (2022)
Background: Patients with vascular cognitive impairment (VCI) are very heterogeneous in both symptoms and type of cerebrovascular pathology. This might be an important reason why there is no symptomatic treatment available for VCI patients. In this s
Externí odkaz:
https://doaj.org/article/5136d3fbb5b24735baf3055b9249b55f
Autor:
Jooske MF Boomsma, Lieza G Exalto, Frederik Barkhof, Anna E Leeuwis, Niels D Prins, Philip Scheltens, Charlotte E Teunissen, Henry C Weinstein, Geert Jan Biessels, Wiesje M van der Flier, On-behalf-of-the-TRACE-VCI-study-group
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 3, Iss , Pp 100141- (2022)
Background: Little is known about the trajectories of cognitive decline in relation to different types of vascular brain injury in patients presenting at a memory clinic with Vascular Cognitive Impairment (VCI). Methods: We included 472 memory clinic
Externí odkaz:
https://doaj.org/article/08118b172fe044f6b71eae9b66e96e37
Autor:
Philip Scheltens, Merja Hallikainen, Timo Grimmer, Thomas Duning, Alida A Gouw, Charlotte E Teunissen, Alle Meije Wink, Paul Maruff, John Harrison, Caroline M van Baal, Suzanne Bruins, Inge Lues, Niels D Prins
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract Background PQ912 is an inhibitor of the glutaminyl cyclase enzyme that plays a central role in the formation of synaptotoxic pyroglutamate-A-beta oligomers. We report on the first clinical study with PQ912 in subjects with biomarker-proven A
Externí odkaz:
https://doaj.org/article/691f429b58a244929af4927237eedec1
Autor:
Inge M W Verberk, MSc, Malika B Laarhuis, MSc, Karlijn A van den Bosch, MSc, Jarith L Ebenau, MD, Mardou van Leeuwenstijn, Niels D Prins, MD, Philip Scheltens, ProfMD, Charlotte E Teunissen, ProfPhD, Wiesje M van der Flier, ProfPhD
Publikováno v:
The Lancet. Healthy Longevity, Vol 2, Iss 2, Pp e87-e95 (2021)
Summary: Background: Serum glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) are putative non-amyloid blood-based biomarkers indicative of ongoing inflammatory and neurodegenerative disease processes. We aimed to assess their progn
Externí odkaz:
https://doaj.org/article/ec1aa80adf93445e8bcddd482872827f
Autor:
Lois Ottenhoff, Everard G. B. Vijverberg, Leonie N. C. Visser, Merike Verijp, Niels D. Prins, Wiesje M. Van der Flier, Sietske A. M. Sikkes
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Introduction In the context of the development of pharmaceutical interventions, expectations and experiences of participants are essential. Their insights may be particularly helpful to address the challenges of recruiting and retaining part
Externí odkaz:
https://doaj.org/article/fd2f7729792e42adae7107f7e497452d
Autor:
Lisa Waterink, Els D. Bakker, Leonie N. C. Visser, Francesca Mangialasche, Miia Kivipelto, Kay Deckers, Sebastian Köhler, Sietske A. M. Sikkes, Niels D. Prins, Philip Scheltens, Wiesje M. van der Flier, Marissa D. Zwan
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
BackgroundThe COVID-19 pandemic has major influence on lifestyle and mental health, which might affect brain-health and increase the risk of cognitive decline, particularly in older adults. We aimed to describe changes in modifiable risk factors rela
Externí odkaz:
https://doaj.org/article/b5728f30e46e486d9d11757e9e59e4b4
Autor:
Jarith L. Ebenau, Sven J. van derLee, Marc Hulsman, Niccolò Tesi, Iris E. Jansen, Inge M.W. Verberk, Mardou vanLeeuwenstijn, Charlotte E. Teunissen, Frederik Barkhof, Niels D. Prins, Philip Scheltens, Henne Holstege, Bart N.M. vanBerckel, Wiesje M. van derFlier
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction We investigated relationships among genetic determinants of Alzheimer's disease (AD), amyloid/tau/neurodegenaration (ATN) biomarkers, and risk of dementia. Methods We studied cognitively normal individuals with subjective cognit
Externí odkaz:
https://doaj.org/article/f7b9d3ce60aa4f109863674dff7bb41b
Autor:
Jarith L. Ebenau, Denise Visser, Sander C. J. Verfaillie, Tessa Timmers, Mardou S. S. A. van Leeuwenstijn, Mara ten Kate, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Niels D. Prins, Ronald Boellaard, Wiesje M. van der Flier, Bart N. M. van Berckel
Publikováno v:
Ebenau, J L, Visser, D, Verfaillie, S C J, Timmers, T, van Leeuwenstijn, M S S A, Kate, M T, Windhorst, A D, Barkhof, F, Scheltens, P, Prins, N D, Boellaard, R, van der Flier, W M & van Berckel, B N M 2023, ' Cerebral blood flow, amyloid burden, and cognition in cognitively normal individuals ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 50, no. 2, pp. 410-422 . https://doi.org/10.1007/s00259-022-05958-8
European Journal of Nuclear Medicine and Molecular Imaging, 50(2), 410-422. Springer Verlag
European Journal of Nuclear Medicine and Molecular Imaging, 50(2), 410-422. Springer Verlag
Abstract Purpose The role of cerebral blood flow (CBF) in the early stages of Alzheimer’s disease is complex and largely unknown. We investigated cross-sectional and longitudinal associations between CBF, amyloid burden, and cognition, in cognitive
Autor:
Sanne Franzen, Jade Smith, Esther van den Berg, Monica Rivera Mindt, Rozemarijn L. van Bruchem‐Visser, Erin L Abner, Lon S. Schneider, Niels D. Prins, Ganesh M Babulal, Janne M. Papma
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Susan Abushakra, John Hey, Kaj Blennow, Philip Scheltens, Eric M. Reiman, Jakub Hort, Katerina Sheardova, Sterre M. Rutgers, Niels D. Prins, Paul Dautzenberg, Ladislav Pazdera, Aidan Power, Martin Tolar
Publikováno v:
Alzheimer's & Dementia. 18