Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Niels C. Berg Nyborg"'
Autor:
Anne Sietske de Boer, David Wederkinck Andersen, Birgitte Schjellerup Wulff, Anne Bugge, Inger Thorup, Trine R. Clausen, Niels C. Berg Nyborg, Rikke Kaae Kirk
Publikováno v:
Toxicology and Applied Pharmacology. 399:115035
Background and aims Cholecystokinin (CCK) may potentially be used to treat obesity. However, it is well-known to induce acute pancreatitis and pancreas neoplasia in rodents, but not in primates. Here we report the nonclinical safety profile of a long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcc8df3b05823d60dcfb6ca23913b2a
https://doi.org/10.1016/j.taap.2020.115035
https://doi.org/10.1016/j.taap.2020.115035
Autor:
Carsten F. Gotfredsen, Marianne O. Larsen, Zaki Salanti, Lotte Bjerre Knudsen, Anne-Marie Mølck, Inger Thorup, Niels C. Berg Nyborg
Publikováno v:
Diabetes. 63:2486-2497
Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2e0b4ff360dbfc2e250989915b260b
https://doi.org/10.2337/db13-1087
https://doi.org/10.2337/db13-1087
Publikováno v:
International Journal of Endocrinology, Vol 2013 (2013)
International Journal of Endocrinology
International Journal of Endocrinology
The aim of the present study was to examine the calcium activity of C8-T5dorsal root ganglion (DRG) neurons from Zucker diabetic fatty rats. In total, 8 diabetic ZDF fatty animals and 8 age-matched control ZDF lean rats were employed in the study. C8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b02c7e6372d1e48fa72cf72d97e91e
https://doi.org/10.1155/2013/532850
https://doi.org/10.1155/2013/532850
Publikováno v:
Diabetes. 61:1243-1249
Glucagon-like peptide (GLP)-1 analogs have been implicated as a risk factor for pancreatitis in humans. We investigated whether liraglutide, the once-daily human GLP-1 analog, induces pancreatitis in rats, mice, and monkeys. Pancreata from mice, rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f8d472032cbd01910e414c90eccb676
https://doi.org/10.2337/db11-0936
https://doi.org/10.2337/db11-0936
Publikováno v:
Antonie van Leeuwenhoek. 83:27-34
A total of 26 strains of wild-type lactic acid bacteria, mainly belonging to Lactococcus lactis and Lactobacillus helveticus, were assayed in vitro for their ability to produce a milk fermentate with inhibitory activity towards angiotensin converting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c61729b434d784efe9a03f707056c418
https://doi.org/10.1023/a:1022993905778
https://doi.org/10.1023/a:1022993905778
Autor:
Niels C. Berg Nyborg, Majid Sheykhzade
Publikováno v:
British Journal of Pharmacology. 132:1235-1246
This study investigates the mechanism of CGRP-induced relaxation in intramural coronary arteries by determining the effect of CGRP on cytosolic Ca2+ concentration ([Ca2+]i) using FURA-2 technique. CGRP concentration-dependently (10 pM – 100 nM) dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c739a5aefa35661863239229d4fa6ab
https://doi.org/10.1038/sj.bjp.0703936
https://doi.org/10.1038/sj.bjp.0703936
Autor:
Majid Sheykhzade, Niels C. Berg Nyborg
Publikováno v:
British Journal of Pharmacology. 130:386-390
We examined the interaction between rat-amylin and relaxations induced by rat-αCGRP and isoprenaline in rat isolated coronary small arteries. Amylin, 0.1–100 nM, had a concentration dependent non-competitive antagonistic effect on rat-αCGRP-induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92538c2beb2697b8b831d99709c9aa4f
https://doi.org/10.1038/sj.bjp.0703316
https://doi.org/10.1038/sj.bjp.0703316
Publikováno v:
British Journal of Pharmacology. 129:1212-1218
This study investigates the effect of partially metabolic controlled long-term (34 weeks) streptozotocin (STZ)-induced diabetes on relaxation and contractile responses of isolated coronary arteries to seven different vasoactive agents. The average fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e1a86d128fa846d122116f479af03a6
https://doi.org/10.1038/sj.bjp.0703159
https://doi.org/10.1038/sj.bjp.0703159
Autor:
Niels C. Berg Nyborg, Majid Sheykhzade
Publikováno v:
European Journal of Pharmacology. 351:53-59
The influence of vessel caliber on rat calcitonin gene-related peptide (rat-alphaCGRP)-induced responses and the reproducibility of rat-alphaCGRP concentration-response curves were investigated in the left intramural coronary artery of Sprague-Dawley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fb54a5464565efed2cc61008d92400
https://doi.org/10.1016/s0014-2999(98)00290-8
https://doi.org/10.1016/s0014-2999(98)00290-8
Autor:
Majid Sheykhzade, Niels C. Berg Nyborg
Publikováno v:
British Journal of Pharmacology. 123:1464-1470
1. In this study we characterized the CGRP-receptor subtype by Schild-plot analysis using the C-terminal fragment, human-alphaCGRP(8-37), a putative competitive CGRP1-receptor selective antagonist. In addition, the effect of rat-alphaCGRP was compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944dc75ea01df07c8067595505bc1c0c
https://doi.org/10.1038/sj.bjp.0701760
https://doi.org/10.1038/sj.bjp.0701760