Zobrazeno 1 - 10
of 547
pro vyhledávání: '"Niels Borregaard"'
Autor:
Kristian Reckzeh, Hüsün Kizilkaya, Alexandra Søgaard Helbo, Montserrat Estruch Alrich, André Gundersen Deslauriers, Amit Grover, Nicolas Rapin, Fazila Asmar, Kirsten Grønbæk, Bo Porse, Niels Borregaard, Dietmar Vestweber, Claus Nerlov, Kim Theilgaard-Mönch
Publikováno v:
Blood Advances, Vol 2, Iss 13, Pp 1628-1632 (2018)
Externí odkaz:
https://doaj.org/article/2f66945dee264ca7845692de80ef5b07
Autor:
Sara Louise Dahl, Joshua S. Woodworth, Christian Johann Lerche, Elisabeth Præstekjær Cramer, Pia Rude Nielsen, Claus Moser, Allan Randrup Thomsen, Niels Borregaard, Jack Bernard Cowland
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Lipocalin-2 is a constituent of the neutrophil secondary granules and is expressed de novo by macrophages and epithelium in response to inflammation. Lipocalin-2 acts in a bacteriostatic fashion by binding iron-loaded siderophores required for bacter
Externí odkaz:
https://doaj.org/article/b3b63c0d7b184b8386b6ce832b7c67d8
Autor:
Jesper Brink Svendsen, Bo Baslund, Elisabeth Præstekjær Cramer, Nicolas Rapin, Niels Borregaard, Jack Bernard Cowland
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164985 (2016)
Jumonji Domain-Containing Protein 3 (JMJD3)/lysine demethylase 6B (KDM6B) is an epigenetic modulator that removes repressive histone marks on genes. Expression of KDM6B mRNA is elevated in leukocytes from patients with ANCA-associated vasculitis (AAV
Externí odkaz:
https://doaj.org/article/e675e878b7e243daa558a48f8dab5c07
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125483 (2015)
The α-defensins, human neutrophil peptides (HNPs) are the predominant antimicrobial peptides of neutrophil granules. They are synthesized in promyelocytes and myelocytes as proHNPs, but only processed in promyelocytes and stored as mature HNPs in az
Externí odkaz:
https://doaj.org/article/e647c7348cd34087916227ac7db29919
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92471 (2014)
Specific granule deficiency (SGD) is a rare congenital disorder characterized by recurrent infections. The disease is caused by inactivating mutations of the CCAAT/enhancer binding protein-ε (C/EBP-ε) gene. As a consequence, specific and gelatinase
Externí odkaz:
https://doaj.org/article/57b30975f284474589c9bcfdc40989a9
Autor:
Maria T Larsen, Christoffer Hother, Mattias Häger, Corinna C Pedersen, Kim Theilgaard-Mönch, Niels Borregaard, Jack B Cowland
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58454 (2013)
The purpose of this study was to describe the microRNA (miRNA) expression profiles of neutrophils and their precursors from the initiation of granulopoiesis in the bone marrow to extravasation and accumulation in skin windows. We analyzed three diffe
Externí odkaz:
https://doaj.org/article/36eac848033041eaa9f8ddf61fe23bf5
Autor:
Prajna Jena, Soumitra Mohanty, Tirthankar Mohanty, Stephanie Kallert, Matthias Morgelin, Thomas Lindstrøm, Niels Borregaard, Steffen Stenger, Avinash Sonawane, Ole E Sørensen
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50345 (2012)
Pathogenic mycobacteria reside in, and are in turn controlled by, macrophages. However, emerging data suggest that neutrophils also play a critical role in innate immunity to tuberculosis, presumably by their different antibacterial granule proteins.
Externí odkaz:
https://doaj.org/article/0230893362ac4e3f9b7578d0c4bba2e2
Autor:
Elisabeth P Cramer, Andreas Glenthøj, Mattias Häger, Anna Juncker-Jensen, Lars H Engelholm, Eric Santoni-Rugiu, Leif R Lund, Ole D Laerum, Jack B Cowland, Niels Borregaard
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39646 (2012)
NGAL/lipocalin-2 is a siderophore-binding protein that is highly expressed in several cancers. It is suggested to confer a proliferative advantage to cancer cells. Its expression has been correlated with aggressiveness of breast cancer as determined
Externí odkaz:
https://doaj.org/article/9969d821ebe74b1a993da31c784a0c16
Autor:
Kirsten Grønbæk, Montserrat Estruch Alrich, Hüsün Kizilkaya, Kristian Reckzeh, Kim Theilgaard-Mönch, Claus Nerlov, Amit Grover, Nicolas Rapin, Fazila Asmar, Alexandra Søgaard Helbo, Niels Borregaard, Bo T. Porse, André Gundersen Deslauriers, Dietmar Vestweber
Publikováno v:
Blood Advances. 2:1628-1632
Key Points EMCN is a novel marker of human HSCs. EMCN is a more specific marker of HSCs than CD34 as it can discriminate HSCs from lineage-committed HPCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245740b888743fd30ef432a4d38498fc
https://doi.org/10.1182/bloodadvances.2018015743
https://doi.org/10.1182/bloodadvances.2018015743
Autor:
Matthias Mörgelin, Anders A. Bengtsson, Niels Fisker, Niels Borregaard, Kristian Assing, Jonathan Sjögren, Tirthankar Mohanty, Anas H. A. Abu-Humaidan, Ole E. Sørensen, Fredrik Kahn
Publikováno v:
Mohanty, T, Sjögren, J, Kahn, F, Abu-Humaidan, A H A, Fisker, N, Assing, K, Mörgelin, M, Bengtsson, A A, Borregaard, N & Sørensen, O E 2015, ' A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa ', Blood, vol. 126, no. 18, pp. 2128-37 . https://doi.org/10.1182/blood-2015-04-641142
Neutrophils are essential for host defense at the oral mucosa and neutropenia or functional neutrophil defects lead to disordered oral homeostasis. We found that neutrophils from the oral mucosa harvested from morning saliva had released neutrophil e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76070ed3d260b66f842b75250706ea3f
https://doi.org/10.1182/blood-2015-04-641142
https://doi.org/10.1182/blood-2015-04-641142