Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Niels Asger Jakobsen"'
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102641- (2023)
Summary: Single-cell assay for transposase-accessible chromatin with sequencing (scATAC-seq) resolves the heterogeneity of epigenetic states across cells but does not typically capture exonic mutations, which limits our knowledge of how somatic mutat
Externí odkaz:
https://doaj.org/article/74639132d5b741ccbc93ab653e811900
Autor:
Curtis A. Lachowiez, Sanam Loghavi, Zhihong Zeng, Tomoyuki Tanaka, Yi June Kim, Hidetaka Uryu, Sven Turkalj, Niels Asger Jakobsen, Marlise R. Luskin, Dzifa Y. Duose, Rebecca S S. Tidwell, Nicholas J. Short, Gautam Borthakur, Tapan M. Kadia, Lucia Masarova, George D. Tippett, Prithviraj Bose, Elias J. Jabbour, Farhad Ravandi, Naval G. Daver, Guillermo Garcia-Manero, Hagop Kantarjian, Jacqueline S. Garcia, Paresh Vyas, Koichi Takahashi, Marina Konopleva, Courtney D. DiNardo
Publikováno v:
Blood Cancer Discovery.
The safety and efficacy of combining the IDH1 inhibitor ivosidenib (IVO) with the BCL2 inhibitor venetoclax (VEN; IVO+VEN) +/- azacitidine (AZA; IVO+VEN+AZA) was evaluated in four cohorts of patients with IDH1-mutated myeloid malignancies (n=31). Mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2ef2e5e66589607245ebefd8e9103d
https://doi.org/10.1158/2643-3230.bcd-22-0205
https://doi.org/10.1158/2643-3230.bcd-22-0205
Autor:
Naser Ansari-Pour, Verena Körber, Niels Asger Jakobsen, Rachel Moore, Nina Claudino, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Simon Newman, Benjamin Kendrick, Adrian Taylor, Rasheed Afinowi-Luitz, Roger Gundle, Bridget Watkins, Kim Wheway, Debra Beazley, Andrew Carr, Paresh Vyas, Thomas Höfer
Publikováno v:
Blood. 140:5753-5754
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1699fc899d8104de7dc0d72bdb740795
https://doi.org/10.1182/blood-2022-166236
https://doi.org/10.1182/blood-2022-166236
Autor:
Sylvie D Freeman, Abin Thomas, Ian Thomas, Paresh Vyas, Amanda Gilkes, Marlen Metzner, Niels Asger Jakobsen, Alison Kennedy, Amy Moore, Nuria Marquez Almuina, Sarah Burns, Sophie King, Georgia M. Andrew, Kathleen M.E. Gallagher, Rob Sellar, Paul Cahalin, Duruta Weber, Mike Dennis, Priyanka Mehta, Steve Knapper, Nigel H. Russell
Publikováno v:
Blood. 140:532-533
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed8191d5c6297f0f472cdb45bcd7a8c8
https://doi.org/10.1182/blood-2022-162245
https://doi.org/10.1182/blood-2022-162245
Autor:
Sven Turkalj, Niels Asger Jakobsen, Angus Groom, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Kevin Clark, E. Ravza Gür, Lance D. Hentges, Paul Sopp, James O.J. Davies, Jim R. Hughes, Paresh Vyas
Publikováno v:
Blood. 140:1193-1194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8ab0bfff0faeef08a8a1256eae3e7c3
https://doi.org/10.1182/blood-2022-163139
https://doi.org/10.1182/blood-2022-163139
Autor:
Merve Aksöz, Grigore-Aristide Gafencu, Bilyana Stoilova, Mario Buono, Yiran Meng, Niels Asger Jakobsen, Marlen Metzner, Sally-Ann Clark, Ryan Beveridge, Supat Thongjuea, Paresh Vyas, Claus Nerlov
Hematopoietic stem cells (HSC) reconstitute multi-lineage human hematopoiesis after clinical bone marrow transplantation and are the cells-of-origin of hematological malignancies. Though HSC provide multi-lineage engraftment, individual murine HSCs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e24586f54d7d4463bba85966472f19b9
https://doi.org/10.1101/2022.01.14.475546
https://doi.org/10.1101/2022.01.14.475546
Autor:
Verena Körber, Naser Ansari-Pour, Niels Asger Jakobsen, Rachel Moore, Nina Claudino, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Simon Newman, Benjamin JL Kendrick, Adrian H Taylor, Rasheed Afinowi-Luitz, Roger Gundle, Bridget Watkins, Kim Wheway, Debra Beazley, Andrew J Carr, Paresh Vyas, Thomas Höfer
Dividing somatic stem cells acquire DNA changes marking different clones. With time, clones can become large, either stochastically through neutral drift, or increased fitness and consequent selection. We present a simple, direct, and general approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::734e24e46824f7a209d9c807605c0600
https://doi.org/10.1101/2021.12.15.472780
https://doi.org/10.1101/2021.12.15.472780
Autor:
Ryan O. Schenck, Niels Asger Jakobsen, Virginia Turati, Darryl Shibata, Paresh Vyas, Simon Leedham, Alexander R.A. Anderson
Publikováno v:
Cancer Research. 82:A019-A019
Clonal hematopoiesis (CH), such as clonal hematopoiesis of indeterminant potential (CHIP), is diagnosed based on somatic genomic alterations in the absence of hematologic malignancy. At present, CHIP is diagnosed using peripheral blood, where putativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0322798b8fb037287172b313c08be13
https://doi.org/10.1158/1538-7445.evodyn22-a019
https://doi.org/10.1158/1538-7445.evodyn22-a019
Autor:
Thomas K. Hiron, Christopher A. O’Callaghan, Gerard Moncayo, Michael T. McCarthy, Alessandro Valli, Niels Asger Jakobsen, Tomoyoshi Soga, Julie Adam
Expression of the cell-surface glycoprotein MHC class I polypeptide-related sequence A (MICA) is induced in dangerous, abnormal, or “stressed” cells, including cancer cells, virus-infected cells, and rapidly proliferating cells. MICA is recognize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25619ba652941439dd119e5fbea9878b
https://doi.org/10.1074/jbc.m117.809459
https://doi.org/10.1074/jbc.m117.809459
Autor:
Paresh Vyas, Niels Asger Jakobsen
The haematological malignancies are a heterogeneous group of neoplastic disorders, which lead to almost 10,000 deaths annually in the UK. Over the past 2 decades, there has been significant progress in our understanding of the pathological mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d1a1ea565807a5f646fb78773471a7
https://doi.org/10.7861/clinmedicine.18-2-s47
https://doi.org/10.7861/clinmedicine.18-2-s47