Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Niels Krogsgaard-Larsen"'
Autor:
Jacob C. Hansen, Silke Kayser, Kasper B. Hansen, Stylianos Iliadis, Niels Krogsgaard-Larsen, Lennart Bunch, Darryl S. Pickering, Jed T. Syrenne, Markus Staudt, Piero Temperini, Younes Larsen, Birgitte Nielsen, Feng Yi, Aleksandra Moroz
Publikováno v:
ACS Chemical Neuroscience. 11:674-701
Competitive antagonists for ionotropic glutamate receptors (iGluRs) are highly valuable tool compounds for studying health and disease states in the central nervous system. However, only few subtype selective tool compounds are available and the disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b74894f5acdfe0a342e18b7b5c2a7a0e
https://doi.org/10.1021/acschemneuro.0c00003
https://doi.org/10.1021/acschemneuro.0c00003
Autor:
Silke, Kayser, Jacob C, Hansen, Markus, Staudt, Aleksandra, Moroz, Younes, Larsen, Piero, Temperini, Feng, Yi, Jed T, Syrenne, Niels, Krogsgaard-Larsen, Stylianos, Iliadis, Birgitte, Nielsen, Kasper B, Hansen, Darryl S, Pickering, Lennart, Bunch
Publikováno v:
ACS Chem Neurosci
Competitive antagonists for ionotropic glutamate receptors (iGluRs) are highly valuable tool compounds for studying health and disease states in the central nervous system. However, only few subtype selective tool compounds are available and the disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9854d2d039a9d944b85aa9789f222513
https://pubmed.ncbi.nlm.nih.gov/32065744
https://pubmed.ncbi.nlm.nih.gov/32065744
Autor:
Liwei Han, Stinne W. Hansen, Karla Frydenvang, Lennart Bunch, Karina Koch, Claudia G. Delgar, Charlotte Møller, Tri H. V. Huynh, Darryl S. Pickering, Niels Krogsgaard-Larsen, Birgitte Nielsen, Patricia M.G.E. Brown, Jette S. Kastrup, Derek Bowie
Publikováno v:
Journal of Medicinal Chemistry. 60:441-457
Ionotropic glutamate receptor antagonists are valuable tool compounds for studies of neurological pathways in the central nervous system. On the basis of rational ligand design, a new class of selective antagonists, represented by (2S,4R)-4-(2-carbox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf41acb2aaafe10e76c5b656ba2b0bfb
https://doi.org/10.1021/acs.jmedchem.6b01516
https://doi.org/10.1021/acs.jmedchem.6b01516
Autor:
Benjamin J. Daniels, Zhanwei Wang, Daniel P. Furkert, Niels Krogsgaard-Larsen, Margaret A. Brimble
Publikováno v:
The Journal of Organic Chemistry. 81:10366-10375
The scalable synthesis of cyclic enecarbamates and their use as convenient precursors of α,β-unsaturated N-acyl iminium ions is reported. The newly developed route overcomes synthetic and reactivity difficulties in previously reported methods, is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5122606d1b65f9545395659ad3079432
https://doi.org/10.1021/acs.joc.6b01343
https://doi.org/10.1021/acs.joc.6b01343
Autor:
Niels Krogsgaard-Larsen, Elizabeth J. Robinson, Anna Matuszek, Jóhannes Reynisson, Margaret A. Brimble, Daniel P. Furkert, Alan Richardson, Euphemia Leung
Publikováno v:
MedChemComm. 6:239-246
Two hit compounds (14 and 62) were identified using virtual high throughput screening (vHTS) inhibiting the autophagy process in A2780 ovarian cancer cells. The expression levels of the LC3-II and p62 autophagy marker proteins were monitored using We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3bb2344a1a1213e711cbbc8ba1b93fb
https://doi.org/10.1039/c4md00420e
https://doi.org/10.1039/c4md00420e
Autor:
Kasper Harpsøe, Claus Tornby Christoffersen, Jan Kehler, P. Brøsen, Niels Krogsgaard-Larsen, Thomas Balle
Publikováno v:
Neurochemical Research. 39:1997-2007
The scientific advances during the 1970ies and 1980ies within the field of dopaminergic neurotransmission enabled the development of a pharmacophore that became the template for design and synthesis of dopamine D2 agonists during the following four d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9e333ceeecb19f3f918d0fc58b3c61
https://doi.org/10.1007/s11064-014-1314-2
https://doi.org/10.1007/s11064-014-1314-2
Autor:
Jan Kehler, Claus Tornby Christoffersen, Niels Krogsgaard-Larsen, Anders A. Jensen, Tenna Juul Schrøder
Publikováno v:
Journal of Medicinal Chemistry. 57:5823-5828
By introducing distal substituents on a tetracyclic scaffold resembling the ergoline structure, two series of analogues were achieved exhibiting subnanomolar receptor binding affinities for the dopamine D2 and serotonin 5-HT6 receptor subtype, respec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbe690a3e60a5cafb61d6fa34dfacd71
https://doi.org/10.1021/jm5003759
https://doi.org/10.1021/jm5003759
Autor:
Niels, Krogsgaard-Larsen, Claudia G, Delgar, Karina, Koch, Patricia M G E, Brown, Charlotte, Møller, Liwei, Han, Tri H V, Huynh, Stinne W, Hansen, Birgitte, Nielsen, Derek, Bowie, Darryl S, Pickering, Jette Sandholm, Kastrup, Karla, Frydenvang, Lennart, Bunch
Publikováno v:
Journal of medicinal chemistry. 60(1)
Ionotropic glutamate receptor antagonists are valuable tool compounds for studies of neurological pathways in the central nervous system. On the basis of rational ligand design, a new class of selective antagonists, represented by (2S,4R)-4-(2-carbox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ae2e6b559db049dff24ff758b719a0f
https://pubmed.ncbi.nlm.nih.gov/28005385
https://pubmed.ncbi.nlm.nih.gov/28005385
Publikováno v:
Chemical Reviews. 111:7981-8006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa10f528daa362523bab9ae7ad50df3
https://doi.org/10.1021/cr2002646
https://doi.org/10.1021/cr2002646
Publikováno v:
Synthesis. 2010:4287-4299
A new convenient three-step synthesis of the privileged CNS scaffold1,2,3,4,10,10a-hexahydropyrazino[1,2- A]indoleshas been developed. The method makes use of an intramolecular carbene-mediatedC-H insertion in phenylpiperazine-derived tosyl-hydrazone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db0c162f1175617298192efc1578ba12
https://doi.org/10.1055/s-0030-1258967
https://doi.org/10.1055/s-0030-1258967