Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Niels, Schaft"'
Autor:
Carola Berking, Gerold Schuler, Olaf Wolkenhauer, Annelies W Turksma, Heiko Bruns, Julio Vera, Martin Eberhardt, Manuel Wiesinger, Beatrice Schuler-Thurner, Cindy Flamann, Markus Vincent Heppt, Shailendra Gupta, Christopher Lischer, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Johannes März, Harald Knorr, Krishna Pal Singh, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen-van Heeren, Bettina Hohberger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Tumor-associated antigens and their derived peptides constitute an opportunity to design off-the-shelf mainline or adjuvant anti-cancer immunotherapies for a broad array of patients. A performant and rational antigen selection pipeline wou
Externí odkaz:
https://doaj.org/article/f5b73ac9110f43bf9d82c89934e31442
Autor:
Niels Schaft, Jan Dörrie, Gerold Schuler, Beatrice Schuler-Thurner, Husam Sallam, Shiri Klein, Galit Eisenberg, Shoshana Frankenburg, Michal Lotem, Areej Khatib
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The treatment of cancer was revolutionized within the last two decades by utilizing the mechanism of the immune system against malignant tissue in so-called cancer immunotherapy. Two main developments boosted cancer immunotherapy: 1) the use of check
Externí odkaz:
https://doaj.org/article/2d8d1f070bcd4679a5f082af5bcbc7c2
Autor:
Felix Pfister, Jan Dörrie, Niels Schaft, Vera Buchele, Harald Unterweger, Lucas R. Carnell, Patrick Schreier, Rene Stein, Markéta Kubánková, Jochen Guck, Holger Hackstein, Christoph Alexiou, Christina Janko
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundImmunotherapy of cancer is an emerging field with the potential to improve long-term survival. Thus far, adoptive transfer of tumor-specific T cells represents an effective treatment option for tumors of the hematological system such as lym
Externí odkaz:
https://doaj.org/article/46cbcad70ccd47019395acaf9ee98ab1
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
Externí odkaz:
https://doaj.org/article/e5126a7dc7bd4bd383c0474bfaf89189
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Dendritic cells (DCs) can be used for therapeutic vaccination against cancer. The success of this therapy depends on efficient tumor-antigen presentation to cytotoxic T lymphocytes (CTLs) and the induction of durable CTL responses by the DCs. Therefo
Externí odkaz:
https://doaj.org/article/05ea4929ce7049ae8b78e017f0c7525d
Autor:
Elias A. T. Koch, Niels Schaft, Mirko Kummer, Carola Berking, Gerold Schuler, Kenichiro Hasumi, Jan Dörrie, Beatrice Schuler-Thurner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Uveal melanoma (UM) is an orphan disease with a mortality of 80% within one year upon the development of metastatic disease. UM does hardly respond to chemotherapy and kinase inhibitors and is largely resistant to checkpoint inhibition. Hence, furthe
Externí odkaz:
https://doaj.org/article/6472911da671458fa687e220434108be
Autor:
Dennis C. Harrer, Bianca Simon, Shin-ichiro Fujii, Kanako Shimizu, Ugur Uslu, Gerold Schuler, Kerstin F. Gerer, Stefanie Hoyer, Jan Dörrie, Niels Schaft
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-17 (2017)
Abstract Background Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineer
Externí odkaz:
https://doaj.org/article/bcf27fff4a0f4695b2497727695d8b7a
Autor:
Naomi C. Bosch, Reinhard E. Voll, Caroline J. Voskens, Stefanie Gross, Barbara Seliger, Gerold Schuler, Niels Schaft, Jan Dörrie
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Background: In therapeutic cancer vaccination, monocyte-derived dendritic cells (moDCs) efficiently activate specific T-cell responses; however, optimizing the activation of innate immune cells could support and improve the antitumor effects. A major
Externí odkaz:
https://doaj.org/article/28f379eb821f4bb394c4e79ae1f9234d
Autor:
Jan B. Boscheinen, Sabrina Thomann, David M. Knipe, Neal DeLuca, Beatrice Schuler-Thurner, Stefanie Gross, Jan Dörrie, Niels Schaft, Christian Bach, Anette Rohrhofer, Melanie Werner-Klein, Barbara Schmidt, Philipp Schuster
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Robust anti-tumor immunity requires innate as well as adaptive immune responses. We have shown that plasmacytoid dendritic cells develop killer cell-like activity in melanoma cell cocultures after exposure to the infectious but replication-deficient
Externí odkaz:
https://doaj.org/article/dcf30f70258e4e309c1f071f6e2ca38d
Autor:
Julio Vera, Gerold Schuler, Jan Dörrie, Niels Schaft, Cornelia Schinzel, Tanushree Jaitly, Martin Eberhardt, Christopher Lischer
Therapeutic anticancer vaccination has been adapted as an immunotherapy in several solid tumors. However, the selection of promising candidates from the total quantity of possible epitopes poses a challenge to clinicians and bioinformaticians alike,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29abc54a36d3630ce2d0513ea7206480
https://doi.org/10.1158/0008-5472.c.6511160.v1
https://doi.org/10.1158/0008-5472.c.6511160.v1
