Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Niels, Krebsfaenger"'
Autor:
Gabriele Schmuck, Gary M. Williams, Alan M. Jeffrey, David Molina, Daniel J. Smart, Klaus D. Brunnemann, Andreas Kampkoetter, Jian-Dong Duan, Niels Krebsfaenger
Publikováno v:
Chemico-Biological Interactions. 203:386-390
Fluoroquinolone (FQ) antibiotics are bacteriocidal through inhibition of the bacterial gyrase and at sufficient concentrations in vitro, they can inhibit the homologous eukaryotic topoisomerase (TOPO) II enzyme. FQ exert a variety of genotoxic effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b2b08013a00080193b77cb35d50c01
https://doi.org/10.1016/j.cbi.2013.01.003
https://doi.org/10.1016/j.cbi.2013.01.003
Autor:
Niels Krebsfaenger, Félix Carvalho, Maria de Lourdes Bastos, Marc Brulport, Franz Oesch, D. de Boer, Matthias Hermes, Helena Carmo, Johannes Doehmer, Jan G. Hengstler, Michael R. Schön, Fernando Remião
Publikováno v:
Toxicology, 229(3), 236-244. Elsevier Ireland Ltd
4-Methylthioamphetamine (4-MTA) belongs to a group of new amphetamine derivatives that is usually sold as "ecstasy" or "flatliners" on the illicit drug market. Large interindividual differences in 4-MTA mediated toxicity have been reported in humans.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef80e790f13595462deca244eebbb2fd
https://doi.org/10.1016/j.tox.2006.10.024
https://doi.org/10.1016/j.tox.2006.10.024
Autor:
Peter Neuhaus, Kathrin Klein, Ulrich M. Zanger, Thomas E. Mürdter, Andreas K. Nussler, Janet K. Coller, Niels Krebsfaenger, Michel Eichelbaum, Renzo Wolbold
Publikováno v:
British Journal of Clinical Pharmacology. 57:105-111
Aims To characterize the interindividual variability and the individual CYP involved in the formation of α-hydroxy-, N-desmethyl- and N-didesmethyl-tamoxifen from tamoxifen. Methods Microsomes from 50 human livers were used to characterize the inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95dc15953869e1814871426e345d4a4b
https://doi.org/10.1046/j.1365-2125.2003.01970.x
https://doi.org/10.1046/j.1365-2125.2003.01970.x
Autor:
Karin Endrizzi, Thomas E. Mürdter, Andreas K. Nussler, Renzo Wolbold, Ulrich M. Zanger, Kathrin Klein, Thomas Lang, Niels Krebsfaenger, Peter Neuhaus, Janet K. Coller, Michel Eichelbaum
Publikováno v:
British Journal of Clinical Pharmacology. 54:157-167
Aims To investigate in a large panel of 50 human liver samples the contribution of CYP2C9, CYP2D6, and CYP3A4 to the overall formation of the potent antioestrogen Z-4-hydroxy-tamoxifen, and how various genotypes affect its formation from tamoxifen. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a068b49db23be6f0b2f59e9807550a
https://doi.org/10.1046/j.1365-2125.2002.01614.x
https://doi.org/10.1046/j.1365-2125.2002.01614.x
Autor:
Niels Krebsfaenger
Publikováno v:
Pharmaceutical Sciences Encyclopedia
Species differences in metabolism may have significant impact on pharmacokinetics and toxicity of drugs. Therefore detailed knowledge of comparative metabolism across species is key for species selection in preclinical safety testing and interpretati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ed8ffa722f6fdca4fff28243b46245
https://doi.org/10.1002/9780470571224.pse056
https://doi.org/10.1002/9780470571224.pse056
Autor:
Niels, Krebsfaenger, Thomas E, Mürdter, Ulrich M, Zanger, Michel F, Eichelbaum, Johannes, Doehmer
Publikováno v:
ALTEX. 20(3)
With more than 30 genetic variants human cytochrome P450 2D6 (CYP2D6) presents the most extensive variation among all cytochromes P450. At the same time, roughly 30% of all drugs are metabolised by CYP2D6. Therefore, V79 Chinese hamster cells were ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed51df67bff113096b84fe50e9a672f9
https://pubmed.ncbi.nlm.nih.gov/12947487
https://pubmed.ncbi.nlm.nih.gov/12947487
Publikováno v:
BMC News and views. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bccad84cad0a7a5c1c01940e30bfef7a
https://doi.org/10.1186/2048-4623-2-s1-op006
https://doi.org/10.1186/2048-4623-2-s1-op006
Autor:
Niels Krebsfaenger, Matthias Hermes, D. de Boer, Jan G. Hengstler, Franz Oesch, Félix Carvalho, Marc Brulport, Johannes Doehmer, Fernando Remião, Maria de Lourdes Bastos, Helena Carmo, Michael R. Schön
Publikováno v:
Toxicology Letters. 172:S40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98a38f6a926bba2026d62538f02a7691
https://doi.org/10.1016/j.toxlet.2007.05.134
https://doi.org/10.1016/j.toxlet.2007.05.134
Autor:
Michael R. Schön, Matthias Hermes, Franz Oesch, Jan G. Hengstler, Maria de Lourdes Bastos, Fernando Remião, Helena Carmo, Niels Krebsfaenger, Johannes Doehmer, Paula S. Branco, Luísa M. Ferreira, Renata Silva, M. Brulport, Félix Carvalho, D. de Boer
Publikováno v:
ResearcherID
OBJECTIVES Remarkable interindividual differences in 3,4-methylenedioxymethamphetamine ('Ecstasy')-mediated toxicity have been reported in humans. Therefore, we tested whether CYP2D6 or its variant alleles as well as CYP3A4 influence the susceptibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaca1043ff8e7e39229f1eaf04e9a2f1
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000241971500004&KeyUID=WOS:000241971500004
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000241971500004&KeyUID=WOS:000241971500004