Výsledky vyhledávání - "Niels, Grabe"

Akademický článek

CNN stability training improves robustness to scanner and IHC-based image variability for epithelium segmentation in cervical histology

Autor: Felipe Miranda Ruiz, Bernd Lahrmann, Liam Bartels, Alexandra Krauthoff, Andreas Keil, Steffen Härtel, Amy S. Tao, Philipp Ströbel, Megan A. Clarke, Nicolas Wentzensen, Niels Grabe

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

BackgroundIn digital pathology, image properties such as color, brightness, contrast and blurriness may vary based on the scanner and sample preparation. Convolutional Neural Networks (CNNs) are sensitive to these variations and may underperform on i

Externí odkaz: https://doaj.org/article/ca9a4f8b047a41a79bf6def099fe001c

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Akademický článek

Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)

Abstract Background Activation of the oncogene yes-associated protein (YAP) is frequently detected in intrahepatic cholangiocarcinoma (iCCA); however, the expression pattern and the functional impact of its paralogue WW domain-containing transcriptio

Externí odkaz: https://doaj.org/article/dffad727f8a042bbb433f912e31ec171

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Akademický článek

Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their

Externí odkaz: https://doaj.org/article/564548dac492461fa165fbbe611c1237

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Akademický článek

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)

Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that

Externí odkaz: https://doaj.org/article/c9223cd55c18449db9d005eb65c4887e

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Akademický článek

Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma

Autor: Nele Kreycy, Christiane Gotzian, Thomas Fleming, Christa Flechtenmacher, Niels Grabe, Peter Plinkert, Jochen Hess, Karim Zaoui

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-9 (2017)

Abstract Background Glyoxalase 1 is a key enzyme in the detoxification of reactive metabolites such as methylglyoxal and induced Glyoxalase 1 expression has been demonstrated for several human malignancies. However, the regulation and clinical releva

Externí odkaz: https://doaj.org/article/3951c6c96c7b48cd9d91e9ee0143cdef

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Akademický článek

Robust and accurate quantification of biomarkers of immune cells in lung cancer micro-environment using deep convolutional neural networks

Autor: Lilija Aprupe, Geert Litjens, Titus J. Brinker, Jeroen van der Laak, Niels Grabe

Publikováno v: PeerJ, Vol 7, p e6335 (2019)

Recent years have seen a growing awareness of the role the immune system plays in successful cancer treatment, especially in novel therapies like immunotherapy. The characterization of the immunological composition of tumors and their micro-environme

Externí odkaz: https://doaj.org/article/ba9a9355e95e4b6ebe9cbfbb801f66b0

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Akademický článek

Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish

Autor: Erika Tsingos, Burkhard Höckendorf, Thomas Sütterlin, Stephan Kirchmaier, Niels Grabe, Lazaro Centanin, Joachim Wittbrodt

Publikováno v: eLife, Vol 8 (2019)

Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka (Oryzias latipes) coordinate their growth rates. NR ce

Externí odkaz: https://doaj.org/article/821cc2715f6040a9a5ccf56d8de0343c

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Akademický článek

Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour doe

Externí odkaz: https://doaj.org/article/6b8b3ea588cd4746baa64e76cce15f72

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Automated Evaluation of p16/Ki-67 Dual-Stain Cytology as a Biomarker for Detection of Anal Precancer in Men Who Have Sex With Men and Are Living With Human Immunodeficiency Virus

Autor: Camryn M Cohen, Nicolas Wentzensen, Bernd Lahrmann, Diane Tokugawa, Nancy Poitras, Liam Bartels, Alexandra Krauthoff, Andreas Keil, Felipe Miranda, Philip E Castle, Thomas Lorey, Brad Hare, Teresa M Darragh, Niels Grabe, Megan A Clarke

Publikováno v: Clin Infect Dis

Background Human papillomavirus–related biomarkers such as p16/Ki-67 “dual-stain” (DS) cytology have shown promising clinical performance for anal cancer screening. Here, we assessed the performance of automated evaluation of DS cytology (autom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0b0decb8aa897a52062a95501a9dbe
https://doi.org/10.1093/cid/ciac211

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