Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Niel C. Hoglen"'
Autor:
James E. Vath, Thomas Edward Hughes, Margaret Wyman, Niel C. Hoglen, Bryan Burkey, Philip Inskeep
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:301-313
Methionine aminopeptidase 2 (MetAP2) inhibition is a promising approach to treating diabetes, obesity, and associated metabolic disorders. Beloranib, a MetAP2 inhibitor previously investigated for treatment of Prader-Willi syndrome, was associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75178b1c01e7f175da71410ab91ce16f
https://doi.org/10.1124/jpet.117.246272
https://doi.org/10.1124/jpet.117.246272
Autor:
Niel C. Hoglen, Scott A. Mobley, Glenn Sipes, John Michael Sauer, R. Clark Lantz, David L. Earnest, Robert S. McCuskey, Edward A. Abril
Publikováno v:
Liver. 17:157-165
Previous studies have shown that large doses of vitamin A potentiate chemical-induced liver injury and that the Kupffer cell is directly involved in this potentiation. Therefore, these studies were designed to determine if Kupffer cells isolated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bb7e77b238bb2ff0f43b9b08419f9d
https://doi.org/10.1111/j.1600-0676.1997.tb00799.x
https://doi.org/10.1111/j.1600-0676.1997.tb00799.x
Autor:
Karen L. Valentino, Ronald W. Busuttil, Douglas G. Farmer, Marian Kaldas, Charles Lassman, Niel C. Hoglen, Jerzy W. Kupiec-Weglinski, Masamichi Katori, Xiu-Da Shen, Dean M. Anselmo
Publikováno v:
Liver Transplantation. 13:361-366
This study examined the efficacy of the caspase inhibitor, IDN-6556, in a rat model of liver ischemia-reperfusion injury. Livers from male Sprague-Dawley rats were reperfused for 120 minutes after 24 hours of 4 degrees C cold storage in University of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de03d9b6ae0d961f35dde855c5df7e7
https://doi.org/10.1002/lt.21016
https://doi.org/10.1002/lt.21016
Autor:
Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
Publikováno v:
Journal of Medicinal Chemistry. 48:6779-6782
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e
https://doi.org/10.1021/jm050307e
Autor:
Niel C. Hoglen, Patricia C. Contreras, Brad P. Hirakawa, Long-Shiuh Chen, Todd Groessl, Craig D. Fisher
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:634-640
The potency, efficacy, and pharmacokinetic properties of IDN-6556 (3-[2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid), a first-in-class caspase inhibitor in clinical trials for the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cd6072fda815132c80b024022dc888
https://doi.org/10.1124/jpet.103.062034
https://doi.org/10.1124/jpet.103.062034
Publikováno v:
Toxicology and Applied Pharmacology. 163:141-148
1,2-Dichlorobenzene (1,2-DCB) is a potent hepatotoxicant in male Fischer 344 (F-344) rats but not in Sprague-Dawley (SD) rats. While Kupffer cell-dependent oxidative stress plays a role in the progression of 1,2-DCB-mediated liver injury, we hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212953414b03c714a9e4ec4fcd34ebce
https://doi.org/10.1006/taap.1999.8860
https://doi.org/10.1006/taap.1999.8860
Autor:
R. Clark Lantz, Niel C. Hoglen, I. Glenn Sipes, Husam S. Younis, L Gunawardhana, Dylan P. Hartley
Publikováno v:
Toxicological Sciences. 46:376-385
1,2-Dichlorobenzene (1,2-DCB) is a potent hepatotoxicant in male Fischer 344 (F344) rats and previous studies have suggested that reactive oxygen species may play a role in the development of hepatotoxicity. Since reactive oxygen species can damage l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4aadfafe1c1d64dbdfcc561dd43b41f
https://doi.org/10.1006/toxs.1998.2523
https://doi.org/10.1006/toxs.1998.2523
Autor:
Niel C. Hoglen, Husam S. Younis, J M Sauer, L E Twerdok, I. G. Sipes, M J Miller, J L Hensel, D R Steup, S P Regan, S J Waterman
Publikováno v:
Toxicological Sciences. 46:176-184
This study was conducted to compare the effects of 60-day dietary exposure (2%) to low melt point paraffin wax (LMPW) on both general liver morphology and Kupffer cell (KC) function and morphology in female F-344 and Sprague-Dawley (SD) rats. Livers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866076e0d4e965cf308eac10bf7844dc
https://doi.org/10.1006/toxs.1998.2509
https://doi.org/10.1006/toxs.1998.2509
Autor:
Niel C. Hoglen, Husam S. Younis, Dylan P. Hartley, Lhanoo Gunawardhana, R. Clark Lantz, I. Glenn Sipes
Publikováno v:
Toxicological Sciences. 46:376-385
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b30672c6424b88cd6420e188bec129
https://doi.org/10.1093/toxsci/46.2.376
https://doi.org/10.1093/toxsci/46.2.376
Publikováno v:
Chemical Research in Toxicology. 10:401-407
The reaction of peroxynitrite with gamma-tocopherol (gamma-TH) in a methanol/potassium phosphate buffer solution results in the formation of four major products, which were identified as 2,7,8-trimethyl-2-(4,8,12-trimethyldecyl)-5-nitro-6-chromanol++
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4cb99ef884f7dee861ef172f8fc448
https://doi.org/10.1021/tx960200h
https://doi.org/10.1021/tx960200h