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Akademický článek

Hypoxia drives HIF2-dependent reversible macrophage cell cycle entry

Autor: Bo Meng, Na Zhao, Petra Mlcochova, Isabella A.T.M. Ferreira, Brian M. Ortmann, Tanja Davis, Niek Wit, Jan Rehwinkel, Simon Cook, Patrick H. Maxwell, James A. Nathan, Ravindra K. Gupta

Publikováno v: Cell Reports, Vol 43, Iss 7, Pp 114471- (2024)

Summary: Low-oxygen conditions (hypoxia) have been associated primarily with cell-cycle arrest in dividing cells. Macrophages are typically quiescent in G0 but can proliferate in response to tissue signals. Here we show that hypoxia (1% oxygen tensio

Externí odkaz: https://doaj.org/article/eadb2615d1c64a0997c73b03a036fcb1

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Akademický článek

A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis

Autor: Anna S. Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M. Ortmann, James A. West, Norbert Volkmar, Anthony W. Martinelli, Zhaoqi Li, Niek Wit, Dennis Vitkup, Arthur Kaser, Paul J. Lehner, James A. Nathan

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Cholesterol biosynthesis is a highly regulated, oxygen-dependent pathway, vital for cell membrane integrity and growth. In fungi, the dependency on oxygen for sterol production has resulted in a shared transcriptional response, resembling pr

Externí odkaz: https://doaj.org/article/c87d491caba847fcaeae18fb670de9f1

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Akademický článek

Author Correction: A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)

Externí odkaz: https://doaj.org/article/1e8df5e5952f458ba4cea0c1b5668fea

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Akademický článek

Author Correction: A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Externí odkaz: https://doaj.org/article/2599fb5071604775b7eff4fa0c444bd5

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Akademický článek

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

Publikováno v: eLife, Vol 11 (2022)

DNA damage response mechanisms have meiotic roles that ensure successful gamete formation. While completion of meiotic double-strand break (DSB) repair requires the canonical RAD9A-RAD1-HUS1 (9A-1-1) complex, mammalian meiocytes also express RAD9A an

Externí odkaz: https://doaj.org/article/57deb83a4c11495681d45121899c60e3

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Akademický článek

Increased formate overflow is a hallmark of oxidative cancer

Autor: Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian M. Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou, Alexei Vazquez

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of

Externí odkaz: https://doaj.org/article/3791b6fce2b1446482c02c147ec6dfd2

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Akademický článek

Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.

Autor: Niek Wit, Peter H L Krijger, Paul C M van den Berk, Heinz Jacobs

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16669 (2011)

Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164)) is a highly conserved, DNA damage-inducible process that is mediated by the E2/E3 complex Rad6/Rad18. This ubiquitylation event recruits translesion synt

Externí odkaz: https://doaj.org/article/3c5f9de1d9ff406ea01c6051fdb4296c

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Akademický článek

The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.

Autor: Peter H L Krijger, Niek Wit, Paul C M van den Berk, Heinz Jacobs

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15236 (2010)

To generate high affinity antibodies during an immune response, B cells undergo somatic hypermutation (SHM) of their immunoglobulin genes. Error-prone translesion synthesis (TLS) DNA polymerases have been reported to be responsible for all mutations

Externí odkaz: https://doaj.org/article/d2e77dad11a5417ab2ff7bdcb316ff15

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