Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Niefang Yu"'
Publikováno v:
Computer Science and Education ISBN: 9789819924455
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbc2ca8a4a486aca81cfd64b5e3453c2
https://doi.org/10.1007/978-981-99-2446-2_44
https://doi.org/10.1007/978-981-99-2446-2_44
Autor:
Youjin Ge, Niefang Yu
Publikováno v:
Synthetic Communications. 51:379-387
Herein a practical and convenient procedure for the one-step synthesis of quinoline-3,4-dicarboxylate derivatives from isatins and β-keto esters in alcohols by sulfuric acid-catalyzed was described...
An efficient and stereoselective procedure of oxidizing disulfide to thiosulfinate 2a using CHP as the oxidant and economically available Ti(O-i-Pr)4/L-DET/H2O as catalysts were developed. The reaction went smoothly under mild conditions with synthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba22b919c10c5e48d8604b24d3c0f21
Publikováno v:
Chemical biologydrug design. 94(2)
A series of compounds similar to Pracinostat that contained benzimidazole ring and N-hydroxyacrylamide attached at 5- or 6-position were designed, synthesized, and evaluated as HDAC inhibitors. It was interesting to find that the corresponding deriva
Autor:
Dizhong Chen, Mui Ling Khoo, Joyce Wei Wei Chang, Kee Chuan Goh, Xin Liu, Anders Poulsen, Siok Kun Goh, Kay Lin Goh, Kanda Sangthongpitag, Niefang Yu, Lye Pek Ling, Zahid Bonday, Changyong Hu, Xukun Wang, Xiaofeng Wu, Brian Dymock, Hwee Hoon Khng, Eric T. Sun, Haishan Wang, Melvin Ng, Lijuan Fang, Ethirajulu Kantharaj, Weiping Deng, Jeanette Marjorie Wood, Ting Lu, Ken Chi Lik Lee, Pauline Yeo
Publikováno v:
Journal of Medicinal Chemistry. 54:4694-4720
A series of 3-(1,2-disubstituted-1H-benzimidazol-5-yl)-N-hydroxyacrylamides (1) were designed and synthesized as HDAC inhibitors. Extensive SARs have been established for in vitro potency (HDAC1 enzyme and COLO 205 cellular IC(50)), liver microsomal
Autor:
Hong Yan Song, Melvin Ng, Zou Yong, Eric T. Sun, Michael Entzeroth, Anders Poulsen, Dizhong Chen, Kee Chuan Goh, Joyce Wei Wei Chang, Kanda Sangthongpitag, Walter Stünkel, Niefang Yu, Zahid Bonday, Haishan Wang, Weiping Deng, Lye Pek Ling, Stéphanie Blanchard, Hwee Hoon Khng, Wai Chung Ong, Lijuan Fang, Xiaofeng Wu, Xukun Wang, Siok Kun Goh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1403-1408
A series of N-hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides were designed and synthesized as novel HDAC inhibitors. General SAR has been established for the substituents at positions 1 and 2, as well as the importance of the ethylene gro
Autor:
Yifa Zhou, Kanda Sangthongpitag, Xukun Wang, Haishan Wang, Blanche Shamoon, Marcia L. Taylor, Michael Entzeroth, Yin Zheng, Janet Rose, BinHui Ni, Kee Chuan Goh, Ze-Yi Lim, Christoph Reinhard, Mark X. Du, Walter Stünkel, Brad Carte, Lijuan Fang, Niefang Yu, Anne B. Jefferson
Publikováno v:
Drug Development Research. 62:349-361
Polo-like kinase 1 (PLK1) has been shown to be involved in cell cycle progression of rapidly proliferating, nontransformed cells as well as tumor cells. In cancer, overexpression of PLK1 contributes to the malignant state by aberrant cell cycle regul
Publikováno v:
Tetrahedron Letters. 41:6993-6996
Substituted 4H-chromene derivatives are a new class of compounds that bind Bcl-2 protein and induce apoptosis in tumor cells. Here we report an efficient synthetic method for the preparation of these compounds from salicylaldehyde derivatives and alk
Publikováno v:
Tetrahedron. 55:13735-13740
Homophthalic anhydride reacts with benzaldehyde in the presence of boron trifluoride-diethyl ether complex to give the cycloadduct 3-phenyl-3,4-dihydroisocoumarin-4-carboxylic acid in good to excellent yield. Under these conditions we did not observe
Publikováno v:
Tetrahedron Letters. 39:829-832
Cycloaddition of imines with homophthalic anhydride in the presence of BF 3 leads to the trans isomers of isoquinolonic acids with a high stereoselectivity and avoids the formation of homophtalic amides. This catalyst extends the scope of the reactio