Výsledky vyhledávání - "Nidhi Nautiyal"

Akademický článek

Rejuvenating bone marrow hematopoietic reserve prevents regeneration failure and hepatic decompensation in animal model of cirrhosis

Autor: Nidhi Nautiyal, Deepanshu Maheshwari, Dhananjay Kumar, E. Pranshu Rao, Dinesh Mani Tripathi, Sandeep Kumar, Sunidhi Diwakar, Manisha Bhardwaj, Sujata Mohanty, Prakash Baligar, Anupama Kumari, Chhagan Bihari, Subhrajit Biswas, S. K. Sarin, Anupam Kumar

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Background and aimBone marrow stem cells (BM-SCs) and their progeny play a central role in tissue repair and regeneration. In patients with chronic liver failure, bone marrow (BM) reserve is severally compromised and they showed marked defects in the

Externí odkaz: https://doaj.org/article/04a49a2070c74049a9ec25a410e8a312

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Akademický článek

Bioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure

Autor: Deepanshu Maheshwari, Dhananjay Kumar, Rakesh Kumar Jagdish, Nidhi Nautiyal, Ashinikumar Hidam, Rekha Kumari, Rashi Sehgal, Nirupama Trehanpati, Sukriti Baweja, Guresh Kumar, Swati Sinha, Meenu Bajpai, Viniyendra Pamecha, Chhagan Bihari, Rakhi Maiwall, Shiv Kumar Sarin, Anupam Kumar

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

ObjectiveThe monocyte–macrophage system is central to the host’s innate immune defense and in resolving injury. It is reported to be dysfunctional in acute-on-chronic liver failure (ACLF). The disease-associated alterations in ACLF monocytes are

Externí odkaz: https://doaj.org/article/edf93f42d18c4e23a4a103806e067e58

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Circulating extracellular vesicles induce monocyte dysfunction and are associated with sepsis and high mortality in cirrhosis

Autor: Ashok Chaudhary, Guresh Kumar, Rakhi Maiwall, Chhagan Bihari, Deepanshu Maheshwari, Nirupama Trehanpati, Jaswinder Singh Maras, Swati Thangariyal, Anupam Kumar, Shiv Kumar Sarin, Sukriti Baweja, Anupma Kumari, Deepika Lal, Gautam Mehta, Nidhi Nautiyal, Preeti Negi

Publikováno v: Liver International. 41:1614-1628

BACKGROUND Sepsis is common in cirrhosis and is often a result of immune dysregulation. Specific stimuli and pathways of inter-cellular communications between immune cells in cirrhosis and sepsis are incompletely understood. Immune cell-derived extra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92151cdfe75f9dc8c88624007852b33d
https://doi.org/10.1111/liv.14875

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Defects in energy metabolism are associated with functional exhaustion of bone marrow mesenchymal stem cells in cirrhosis

Autor: Dhananjay, Kumar, Deepanshu, Maheshwari, Nidhi, Nautiyal, Smriti, Shubham, Sheetalnath, Rooge, Lovkesh, Anand, Ashish, Vyas, Rekha, Kumari, Shvetank, Sharma, Chhagan, Bihari, Sujata, Mohanty, Rakhi, Maiwall, Anupam, Kumar, Shiv Kumar, Sarin

Publikováno v: Am J Stem Cells

Objectives: Cellular and functional exhaustion of bone marrow mesenchymal stem cells (BM-MSC) is significantly associated with the loss of HSCs and hepatic osteodystrophy in cirrhosis. The molecular mechanisms underlying the dysfunction of BM-MSCs ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b79fb132424bedbe627c4bc6da40a991
https://pubmed.ncbi.nlm.nih.gov/35295591

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Establishment of a Murine Model of Acute-on-Chronic Liver Failure with Multi-organ Dysfunction

Autor: Nidhi Nautiyal, Deepanshu Maheshwari, Dhananjay Kumar, Rekha Kumari, Suchi Gupta, Sachin Sharma, Sujata Mohanty, Anupama Parasar, Chhagan Bihari, Subhrajit Biswas, Archana Rastogi, Rakhi Maiwall, Anupam Kumar, Shiv Kumar Sarin

Background and Aims: Acute-on-chronic liver failure (ACLF) is a distinct clinical entity with high probability of organ failure and mortality. Experimental models of ACLF are needed to understand the pathophysiology and natural course of the disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9cea8d6c1d9357bbd3627b015ed91a9
https://doi.org/10.21203/rs.3.rs-438031/v1

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Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction

Autor: Subhrajit Biswas, Dhananjay Kumar, Dinesh M. Tripathi, Rekha Kumari, Sachin Sharma, Rakhi Maiwall, Sujata Mohanty, Archana Rastogi, Suchi Gupta, Deepanshu Maheshwari, Nidhi Nautiyal, Anupam Kumar, Chhagan Bihari, Shiv Kumar Sarin, Anupama Parasar

Publikováno v: Hepatology international. 15(6)

Acute-on-chronic liver failure (ACLF) is a distinct clinical entity with high probability of organ failure and mortality. Since patients generally present late, experimental models are needed to understand the pathophysiology and natural course of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02833a9f86ae71576ddc1376b31ece95
https://pubmed.ncbi.nlm.nih.gov/34435344

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Standard-Volume Plasma Exchange Improves Outcomes in Patients With Acute Liver Failure: A Randomized Controlled Trial

Autor: R. P. Mathur, Meenu Bajpai, Anupam Kumar, Nirupama Trehan Pati, Manish Sharma, Rakesh Kumar Jagdish, Ashini Hidam, Ankit Bharadwaj, Akanksha Singh, Ashok Choudhury, Tanvi Agarwal, Shiv Kumar Sarin, H. V. Tevethia, Guresh Kumar, Rakhi Maiwall, Nidhi Nautiyal, Rajan Vijayaraghavan

Publikováno v: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 20(4)

Background High volume plasma-exchange (HVPE) improves survival in patients with acute liver failure (ALF), but apprehension regarding volume overload and worsening of cerebral edema remain. Methods In an open-label randomized controlled trial, 40 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3764af0ea9c2e7fa1f51ef3e561dee
https://pubmed.ncbi.nlm.nih.gov/33524593

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