Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nidhanapati K. Raghavendra"'
Autor:
Madhavi Latha Yadav Bangaru, PhD, Ravi Kumar Medabalimi, Sobhan Babu, PhD, Nidhanapati K. Raghavendra, PhD
Publikováno v:
SoftwareX, Vol 16, Iss , Pp 100881- (2021)
Insertion of silent mutations allowing for restriction site modification aids in the screening of successful mutants during site directed mutagenesis. Introducing a new restriction site requires the analysis of degenerate sequences within mutant prim
Externí odkaz:
https://doaj.org/article/cd0ed638cc514d7999cb829537c20ff8
Publikováno v:
SoftwareX, Vol 16, Iss, Pp 100881-(2021)
Insertion of silent mutations allowing for restriction site modification aids in the screening of successful mutants during site directed mutagenesis. Introducing a new restriction site requires the analysis of degenerate sequences within mutant prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d471c3567ace4600e38e8868688b623
http://www.sciencedirect.com/science/article/pii/S2352711021001448
http://www.sciencedirect.com/science/article/pii/S2352711021001448
Publikováno v:
Chemical Biology & Drug Design. 91:1133-1140
Alkaloids are a class of organic compounds with a wide range of biological properties, including anti-HIV activity. The 1,2,3,4-tetrahydroisoquinoline is a ubiquitous structural motif of many alkaloids. Using a short and an efficient route for synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d25fcdbe4d2bf04119e0a29e83bf97
https://doi.org/10.1111/cbdd.13175
https://doi.org/10.1111/cbdd.13175
Publikováno v:
Biochemical and biophysical research communications. 490(2)
Lens-epithelium-derived-growth factor (LEDGF/p75) is an essential host protein for integration of HIV-1 DNA into host genome. Earlier alanine scanning mutational analysis has revealed that residues I365, D366 and F406 in the integrase binding domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60e0489bef9d41994f20e0f9596ad3a
https://pubmed.ncbi.nlm.nih.gov/28610923
https://pubmed.ncbi.nlm.nih.gov/28610923
Publikováno v:
Nucleic Acids Research
Integration is an essential step in the retroviral lifecycle, and the lentiviral integrase binding protein lens epithelium-derived growth factor (LEDGF)/p75 plays a crucial role during human immunodeficiency virus type 1 (HIV-1) cDNA integration. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0412a12986bdb9700b7265ab41cdcce
https://doi.org/10.1093/nar/gkm1127
https://doi.org/10.1093/nar/gkm1127
Publikováno v:
Frontiers in bioscience (Landmark edition). 17(3)
Type III restriction-modification (R-M) enzymes need to interact with two separate unmethylated DNA sequences in indirectly repeated, head-to-head orientations for efficient cleavage to occur at a defined location next to only one of the two sites. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a24149873f35f2fa2dddd26430e0d3b
https://pubmed.ncbi.nlm.nih.gov/22201792
https://pubmed.ncbi.nlm.nih.gov/22201792
Autor:
Nidhanapati K. Raghavendra, Sonja Hess, Mamuka Kvaratskhelia, Li Wu, Robert Graham, Nikolozi Shkriabai
Publikováno v:
Retrovirology
Retrovirology, Vol 7, Iss 1, p 66 (2010)
Retrovirology, Vol 7, Iss 1, p 66 (2010)
An integrated HIV-1 genomic DNA leads to an infected cell becoming either an active or a latent virus-producing cell. Upon appropriate activation, a latently infected cell can result in production of progeny viruses that spread the infection to uninf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9178ab95fc98179dea3c0586d8f80c46
https://resolver.caltech.edu/CaltechAUTHORS:20101027-100244817
https://resolver.caltech.edu/CaltechAUTHORS:20101027-100244817
Retroviral replication proceeds through the formation of a provirus, an integrated DNA copy of the viral RNA genome. The linear cDNA product of reverse transcription is the integration substrate and two different integrase activities, 3' processing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb51b42c5925a38c63ab0d3263ac85a
https://europepmc.org/articles/PMC2673482/
https://europepmc.org/articles/PMC2673482/
Autor:
Peter Cherepanov, Alan Engelman, Ming-Chieh Shun, Paul Kellam, Janet E. Daigle, Nick Vandegraaff, Nidhanapati K. Raghavendra, Siobhan M. Hughes
LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their enzymatic activities and chromosomal association. A novel genetic knockout model was established that allowed us for the first time to analyze HIV-1 integration in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac47c3918df1a021003a80c3f10709f
https://europepmc.org/articles/PMC1920171/
https://europepmc.org/articles/PMC1920171/
Publikováno v:
Virology. 360(1)
An integrase dimer can process and integrate a single HIV-1 DNA end in vitro, whereas a tetramer is required to integrate two ends. LEDGF/p75 can potently stimulate integrase activity, but its effects on half- versus full-site integration have not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc30d77ea00bcc2d17c613e4ce466558
https://pubmed.ncbi.nlm.nih.gov/17258258
https://pubmed.ncbi.nlm.nih.gov/17258258