Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nidal F. Farraj"'
Publikováno v:
European Journal of Pharmaceutical Sciences. 6:1-10
Granulocyte-colony stimulating factor (G-CSF) was administered to sheep in three different nasal formulations and as a subcutaneous injection. The nasal formulations were: a solution containing L-alpha-lysophosphatidylglycerol (LPG), a powder formula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec878465eae8cb9bcacbdf83a887e484
https://doi.org/10.1016/s0928-0987(97)00057-2
https://doi.org/10.1016/s0928-0987(97)00057-2
Autor:
Michael Hinchcliffe, Julie L. Richardson, Luca Benedetti, Lisbeth Illum, Joanne Whetstone, A.N. Fisher, Peter James Watts, Nidal F. Farraj
Publikováno v:
Journal of Controlled Release. 42:133-142
The distribution and the retention time of a novel bioadhesive intravaginal delivery system based on HYAFF microspheres were studied in a sheep model. In a preliminary experiment, the vagina of the ewe was outlined by gamma scintigraphy following vag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4183901f7470f3305686530119068e
https://doi.org/10.1016/0168-3659(96)01451-4
https://doi.org/10.1016/0168-3659(96)01451-4
Autor:
S.S. Davis, Nidal F. Farraj, Paul N. Shaw, A.N. Fisher, Lisbeth Illum, M. Pawula, David A. Barrett
Publikováno v:
Biopharmaceutics & Drug Disposition. 17:717-724
The pharmacokinetics of morphine-6-glucuronide (M6G) after both intravenous dosing and nasal administration were studied in sheep. The nasal formulation consisted of M6G in combination with an absorption promoting delivery system in the form of chito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::646643a75b58c5e66da40adbed4ae5e2
https://doi.org/10.1002/(sici)1099-081x(199611)17:8<717::aid-bdd985>3.0.co
https://doi.org/10.1002/(sici)1099-081x(199611)17:8<717::aid-bdd985>3.0.co
Publikováno v:
European Journal of Pharmaceutical Sciences. 1:229-236
Rat erythrocytes, a natural biological model membrane, were used in this study to demonstrate the haemolytic effects of some absorption enhancers and cyclodextrins alone and in combined formulations. The order of haemolytic potency was found to be LP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae9fcc54081810aab9a6e5801d30581
https://doi.org/10.1016/0928-0987(94)90016-7
https://doi.org/10.1016/0928-0987(94)90016-7
Publikováno v:
Journal of Controlled Release. 29:133-141
The use of hyaluronic acid ester microspheres for the intranasal delivery of insulin was investigated in sheep. The formulations were based on two types of microspheres produced from the same polymer but using different stabilising agents. Furthermor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b2f172185207d1445876cdf1768b404
https://doi.org/10.1016/0168-3659(94)90129-5
https://doi.org/10.1016/0168-3659(94)90129-5
Publikováno v:
Pharmaceutical Research. 11:1186-1189
A nasal solution formulation of the cationic material chitosan was shown to greatly enhance the absorption of insulin across the nasal mucosa of rat and sheep. The absorption promoting effect was concentration dependent with the optimal efficacy obta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5783b0394cb72c620c2f7291d23c825
https://doi.org/10.1023/a:1018901302450
https://doi.org/10.1023/a:1018901302450
Publikováno v:
International Journal of Pharmaceutics. 88:319-325
Insulin was administered vaginally to sheep as an aqueous solution and as a lyophilised powder with bioadhesive starch microspheres. The effect of lysophosphatidylcholine (LPC) on the vaginal absorption of insulin from both formulations was studied.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2557d8d1ef0a90dafc5d765aca2b299d
https://doi.org/10.1016/0378-5173(92)90330-5
https://doi.org/10.1016/0378-5173(92)90330-5
Autor:
Inderjit Jabbal-Gill, Nidal F. Farraj, Lisbeth Illum, Bente Rose Johansen, S.S. Davis, A.N. Fisher, Derek T. O'Hagan
Publikováno v:
International Journal of Pharmaceutics. 74:147-156
The effect of L-α-lysophosphatidylcholine (LPC) on the nasal absorption of human growth hormone (hGH) in anaesthetised rats. conscious rabbits and sheep, has been examined. LPC was shown to be an effective enhancer of nasal hGH absorption in three d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dc7f2b7bb2abd4cd2d4dc692e9edcab
https://doi.org/10.1016/0378-5173(91)90231-c
https://doi.org/10.1016/0378-5173(91)90231-c
Publikováno v:
International Journal of Pharmaceutics. 63:207-211
This paper describes an assessment of the potential of using bioadhesive microspheres as a nasal delivery system for biosynthetic human growth hormone (hGH) in sheep. The microsphere system was used alone and in combination with a biological surfacta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e87dc9a9bef12cc69e9f30ec9c86220
https://doi.org/10.1016/0378-5173(90)90126-o
https://doi.org/10.1016/0378-5173(90)90126-o
Publikováno v:
Journal of Controlled Release. 13:253-261
The use of the bioadhesive microsphere system for the intranasal delivery of insulin was investigated in sheep. The effect of combining the above system with lysophosphatidylcholine, as a biological absorption enhancer, was also assessed. For compari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49d26ac5d7bdc37b498bae9163f5e907
https://doi.org/10.1016/0168-3659(90)90016-m
https://doi.org/10.1016/0168-3659(90)90016-m