Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Nida Meednu"'
Autor:
Richard D. Bell, Matthew Brendel, Maxwell A. Konnaris, Justin Xiang, Miguel Otero, Mark A. Fontana, Zilong Bai, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Daria M. Krenitsky, Nida Meednu, Javier Rangel-Moreno, Dagmar Scheel-Toellner, Hayley Carr, Saba Nayar, Jack McMurray, Edward DiCarlo, Jennifer H. Anolik, Laura T. Donlin, Dana E. Orange, H. Mark Kenney, Edward M. Schwarz, Andrew Filer, Lionel B. Ivashkiv, Fei Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Rheumatoid arthritis (RA) is a complex immune-mediated inflammatory disorder in which patients suffer from inflammatory-erosive arthritis. Recent advances on histopathology heterogeneity of RA synovial tissue revealed three distinct phenotyp
Externí odkaz:
https://doaj.org/article/b17d2655ca764faea6b9cae2cefd3a7a
Autor:
Garrett Dunlap, Aaron Wagner, Nida Meednu, Ruoqiao Wang, Fan Zhang, Jabea Cyril Ekabe, Anna Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Vivian P. Bykerk, Laura T. Donlin, Susan M. Goodman, Gary S. Firestein, David L. Boyle, V. Michael Holers, Larry W. Moreland, Darren Tabechian, Costantino Pitzalis, Andrew Filer, Soumya Raychaudhuri, Michael B. Brenner, Juilee Thakar, Andrew McDavid, Deepak A. Rao, Jennifer H. Anolik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify
Externí odkaz:
https://doaj.org/article/b76b85a9921847d4919133eeb47ed023
Autor:
Nida Meednu, Javier Rangel-Moreno, Fan Zhang, Katherine Escalera-Rivera, Elisa Corsiero, Edoardo Prediletto, Edward DiCarlo, Susan Goodman, Laura T. Donlin, Soumya Raychauduri, Michele Bombardieri, Costantino Pitzalis, Dana E. Orange, Andrew McDavid, Jennifer H. Anolik
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110766- (2022)
Summary: Ectopic lymphoid structures (ELS) can develop in rheumatoid arthritis (RA) synovial tissue, but the precise pathways of B cell activation and selection are not well understood. Here, we identify a synovial B cell population characterized by
Externí odkaz:
https://doaj.org/article/d2589dc291814ca69cf6bbe41b34d502
Autor:
Andrew Filer, Michael H Weisman, Judith A James, Kenneth Kalunian, Michelle A Petri, Chaim Putterman, H Michael Belmont, Ilfita Sahbudin, Karim Raza, Maria Dall'Era, Jill P Buyon, Diane L Kamen, Karen Salomon-Escoto, Kazuyoshi Ishigaki, Patrick Dunn, David Wofsy, Michele Bombardieri, Vivian Bykerk, Myles Lewis, Ming Wu, Soumya Raychaudhuri, Hemant Suryawanshi, Thomas Tuschl, Christopher Ritchlin, Maureen McMahon, Jennifer Grossman, Philip M Carlucci, Alessandra Nerviani, Peter M Izmirly, Fan Zhang, Felice Rivellese, Joan Bathon, Zhu Zhu, Qian Xiao, Jessica Li, Holden Maecker, Nir Hacohen, Rong Mao, Jennifer Anolik, Javier Rangel-Moreno, Nida Meednu, Susan Goodman, Lindsy Forbess, Mariko Ishimori, Kevin Deane, David Hildeman, Yuhong Li, Laura Hughes, Robert Clancy, ANNE DAVIDSON, Matthias Kretzler, Larry Moreland, Harris Perlman, Peter Gregersen, Celine C Berthier, Andrea Fava, David Boyle, Derek M Fine, Ami Ben-Artzi, P J Utz, Melanie Smith, Beatrice Goilav, Carla Cuda, Andrew McDavid, Deepak A Rao, Joshua Keegan, Ilya Korsunsky, Joel Guthridge, Kevin Wei, Arnon Arazi, Thomas Eisenhaure, Michael Brenner, Susan Macwana, Pavel Morozov, Manjunath Kustagi, Gerald Watts, Kristina K Deonaraine, Jose Monroy-Trujillo, Mohamed G Atta, Kristin Haag, William Apruzzese, Sean Connery, Fernanda Payan-Schober, Kerry Cho, Jennifer Goff, Aparna Nathan, Joseph Mears, Nghia Millard, Kathryn Weinand, Saori Sakaue, Bill Robinson, Wade DeJager, Louis Bridges, Laura Donlin, Edward DiCarlo, Amit Lakhanpal, Heather Sherman, Anvita Singaraju, Lorien Shakib, Brendan Boyce, Darren Tabechian, Jen Albrecht, James Lederer, A Helena Jonsson, Daimon Simmons, Gregory Keras, Adam Chicoine, Zhihan Jian Li, Mandy McGeachy, Gary Firestein, Arnold Ceponis, Diane Horowitz, Salina Dominguez, Arthur Mandelin, Anjali Thakrar, Mike Holers, Jennifer Seifert, Constanino Pitzalis, Ellen Gravallese, Jennifer Barnas, Raymond Hsu, Steven Woodle, Paul Hoover, Michael Peters, Tony Jones, David Lieb, Jeffrey Hodgin, Raji Menon
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss 1 (2021)
Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating i
Externí odkaz:
https://doaj.org/article/e3722c73b6ce45bba6e56c13af3b5745
Autor:
Wen Sun, Nida Meednu, Alexander Rosenberg, Javier Rangel-Moreno, Victor Wang, Jason Glanzman, Teresa Owen, Xichao Zhou, Hengwei Zhang, Brendan F. Boyce, Jennifer H. Anolik, Lianping Xing
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
B cells contribute to rheumatoid arthritis pathogenesis and bone erosion, but the underlying mechanisms are still unclear. Here the authors show, using mouse models and patient tissues, that B cells directly inhibit osteoblast differentiation by prod
Externí odkaz:
https://doaj.org/article/879bcc165f4342d5914461b4c9efd208
Autor:
Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M. Eisenhaure, Shuqiang Li, Edward P. Browne, Adam Chicoine, Danielle Sutherby, Akiko Noma, Accelerating Medicines Partnership RA/SLE Network, Chad Nusbaum, Stephen Kelly, Alessandra B. Pernis, Lionel B. Ivashkiv, Susan M. Goodman, William H. Robinson, Paul J. Utz, James A. Lederer, Ellen M. Gravallese, Brendan F. Boyce, Nir Hacohen, Costantino Pitzalis, Peter K. Gregersen, Gary S. Firestein, Soumya Raychaudhuri, Larry W. Moreland, V. Michael Holers, Vivian P. Bykerk, Andrew Filer, David L. Boyle, Michael B. Brenner, Jennifer H. Anolik
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims
Externí odkaz:
https://doaj.org/article/f1834e16a4ee4cddb44b1feb039eb118
Autor:
Marcy B. Bolster, Darren Tabechian, Bethany Marston, Edwin A. Smith, Ellen Goldmuntz, Richard M. Keating, Lynette Keyes-Elstein, Jeffrey R. Curtis, Andreea Coca, Karen D. Boyle, Nida Meednu, Jennifer H. Anolik, Jennifer Barnard, Ralf G. Thiele, Jonathan Graf, Beverly Welch, Meggan Mackay, Kelly Callahan
Publikováno v:
Arthritis & Rheumatology. 74:200-211
Objective B cells can become activated in germinal center (GC) reactions in secondary lymphoid tissue and ectopic GCs in synovium in RA that may be TNF and lymphotoxin (LT) dependent. Here we characterized the peripheral B cell compartment longitudin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a1178be48dc90d4a4f24a09efa9760
https://doi.org/10.1002/art.41941
https://doi.org/10.1002/art.41941
Autor:
Jennifer L. Barnas, Diana F Alzamareh, Cameron Baker, Andrew McDavid, R. John Looney, Jennifer H. Anolik, Nida Meednu, Jennifer Albrecht
Publikováno v:
J Immunol
Type I IFN is essential for viral clearance but also contributes to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), via aberrant nucleic acid–sensing pathways, leading to autoantibody production. Type III IFN (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de19999f91cbbb692183b53ca0bdb331
https://doi.org/10.4049/jimmunol.2100339
https://doi.org/10.4049/jimmunol.2100339
Autor:
Fan Zhang, Edoardo Prediletto, Javier Rangel-Moreno, Costantino Pitzalis, Michele Bombardieri, Edward F. DiCarlo, Jennifer H. Anolik, Elisa Corsiero, Katherine Escalera-Rivera, Soumya Raychauduri, Nida Meednu, Andrew McDavid, Susan M. Goodman, Laura T. Donlin, Dana E. Orange
Ectopic lymphoid structures (ELS) can develop in rheumatoid arthritis (RA) synovial tissue, but the precise pathways of B cell activation and selection are not well understood. Here, we identified a unique B cell population in the synovium characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::125135c3c11615128bef8c78f467155a
https://doi.org/10.1101/2021.05.14.443150
https://doi.org/10.1101/2021.05.14.443150
Autor:
Javier Rangel-Moreno, Neha Nandedkar-Kulkarni, Jennifer H. Anolik, Douglas G Widman, Nida Meednu
Publikováno v:
Poster presentations.
Background SLE is an autoimmune disease characterized by activation of the innate and adaptive arms of the immune system. Recently the nuclear export protein exportin-1 (XPO1) has surfaced as an attractive target for the treatment of SLE. Verdinexor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e8e134998a66662a635819686d227b
https://doi.org/10.1136/lupus-2020-eurolupus.183
https://doi.org/10.1136/lupus-2020-eurolupus.183