Zobrazeno 1 - 10
of 1 545
pro vyhledávání: '"Nicotinamide riboside"'
Autor:
Edwin R. Miranda, Pallavi Varshney, Corey E. Mazo, James Shadiow, Andrew T. Ludlow, Jacob M. Haus
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103300- (2024)
Glyoxalase I (GLO1) is the primary enzyme for detoxification of the reactive dicarbonyl methylglyoxal (MG). Loss of GLO1 promotes accumulation of MG resulting in a recapitulation of diabetic phenotypes. We previously demonstrated attenuated GLO1 prot
Externí odkaz:
https://doaj.org/article/318951f6a16d406dbf8a1199a23cdddf
Autor:
Sandra Carrera-Juliá, Elena Obrador, Rafael López-Blanch, María Oriol-Caballo, Paz Moreno-Murciano, José M. Estrela
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
A recent pilot study in amyotrophic lateral sclerosis (ALS) patients analyzed the effect of a Mediterranean diet (MeDi) supplemented with nicotinamide riboside (NR, a NAD+ promoter), pterostilbene (PTER, a natural antioxidant) and/or coconut oil on a
Externí odkaz:
https://doaj.org/article/42d8156464c14488a2c5d3b9970a6439
Autor:
Giorgio Turconi, Farhan Alam, Tanima SenGupta, Sini Pirnes-Karhu, Soophie Olfat, Mark S. Schmidt, Kärt Mätlik, Ana Montaño-Rodriguez, Vladimir Heiskanen, Daniel Garton, Petteri T. Piepponen, Charles Brenner, Carina I. Holmberg, Hilde Nilsen, Eija Pirinen, Jaan-Olle Andressoo
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34355- (2024)
Parkinson's disease (PD) is associated with a reduction in 26/20S proteasome and mitochondrial function and depletion of dopamine. Activation of mitochondrial function with the NAD+ precursor nicotinamide riboside (NR) is a potential therapeutic for
Externí odkaz:
https://doaj.org/article/ac4f73d8f115461db81a3d5dd4a624da
Autor:
Yan Li, Chunjia Zhang, Zihan Li, Fan Bai, Yingli Jing, Han Ke, Shuangyue Zhang, Yitong Yan, Yan Yu
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 2, Pp 1291-1307 (2024)
Changes in intracellular nicotinamide adenine dinucleotide (NAD+) levels have been observed in various disease states. A decrease in NAD+ levels has been noted following spinal cord injury (SCI). Nicotinamide riboside (NR) serves as the precursor of
Externí odkaz:
https://doaj.org/article/908e806ced9a46b4ba14a9bfaa72b439
Autor:
Alejandro Marmolejo-Garza, Laurent Chatre, Deborah L. Croteau, Alejandro Herron-Bedoya, Minh Danh Anh Luu, Benoit Bernay, Julien Pontin, Vilhelm A. Bohr, Erik Boddeke, Amalia M. Dolga
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106645- (2024)
Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust cognitive benefits and alleviates neuroinflammation in Alzheimer's Disease (AD) mouse models without decreasing beta-amyloid plaque pathology. Su
Externí odkaz:
https://doaj.org/article/4ee99df2197a4223b78289600027be29
Akademický článek
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Autor:
Jingting Zhang, Fu Chen
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116701- (2024)
Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) have received considerable attention as anti-aging and anti-metabolic disease nutraceuticals. However, few studies have focused on their role in ameliorating hepatic metabolic disturban
Externí odkaz:
https://doaj.org/article/0658b1dc3eb2468ba3abf843dc321351
Autor:
Juan Carlos Rivera, Jorge Espinoza-Derout, Kamrul M. Hasan, Jocelyn Molina-Mancio, Jason Martínez, Candice J. Lao, Martin L. Lee, Desean L. Lee, Julian Wilson, Amiya P. Sinha-Hikim, Theodore C. Friedman
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionCigarettes containing nicotine (Nic) are a risk factor for the development of cardiovascular and metabolic diseases. We reported that Nic delivered via injections or e-cigarette vapor led to hepatic steatosis in mice fed with a high-fat d
Externí odkaz:
https://doaj.org/article/61f4887ed95b417f94add5bd981abdea
Publikováno v:
JIMD Reports, Vol 64, Iss 6, Pp 417-423 (2023)
Abstract Phospho‐ribosyl‐pyrophosphate synthetase 1 (PRPS1) deficiency is secondary to loss of function variants in PRPS1. This enzyme generates phospho‐ribosyl‐pyrophosphate (PRPP), which is utilized in the synthesis of purines, nicotinamide
Externí odkaz:
https://doaj.org/article/f4215bb5b6d6428aaa4b3f1ab9d236a2
Autor:
Shuting Qiu, Shihan Shao, Yunheng Zhang, Yingying Zhang, Jie Yin, Yu Hong, Jun Yang, Xiaohua Tan, Chunhong Di
Publikováno v:
Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101655- (2024)
Background: Previous studies have shown that the nicotinamide adenine dinucleotide (NAD+) precursors, nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), protect against endogenously or exogenously induced DNA damage. However, whether t
Externí odkaz:
https://doaj.org/article/c0adc1e1d3dc455f8475cefd006596b4