Výsledky vyhledávání - "Nicolo Manaresi"

Akademický článek

Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential

Externí odkaz: https://doaj.org/article/3ccca0e5b5dc46c78df201565348528a

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Abstract 6087: Evaluation of intra-tumor heterogeneity by single-cell copy number profiling of circulating multiple myeloma cells using Shannon index

Autor: Alberto Ferrarini, Claudio Forcato, Valentina del Monaco, Mario Terracciano, Marianna Garonzi, Massimiliano Pellicano, Genny Buson, Francesca Fontana, Paola Tononi, Nicolo Manaresi

Publikováno v: Cancer Research. 82:6087-6087

Tumors develop through an evolutionary process in which genomic lesions accumulate in different coexisting subclones leading to intra-tumor heterogeneity (ITH). ITH allows the tumor to adapt to microenvironments and to resist therapies and has been s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::747d5316dabeba6d7a10796821f099ce
https://doi.org/10.1158/1538-7445.am2022-6087

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Akademický článek

Circulating tumor cell copy-number heterogeneity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

Autor: Marianne Oulhen, Patrycja Pawlikowska, Tala Tayoun, Marianna Garonzi, Genny Buson, Claudio Forcato, Nicolò Manaresi, Agathe Aberlenc, Laura Mezquita, Yann Lecluse, Pernelle Lavaud, Charles Naltet, David Planchard, Benjamin Besse, Françoise Farace

Publikováno v: npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)

Abstract Gatekeeper mutations are identified in only 50% of the cases at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors (TKIs). Circulating tumor cells (CTCs) are relevant tools to identify additional resistance mechanisms

Externí odkaz: https://doaj.org/article/17945349780b47ecb1ff35beb8ce4404

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Akademický článek

Genetic Characterization of Cancer of Unknown Primary Using Liquid Biopsy Approaches

Autor: Noemi Laprovitera, Irene Salamon, Francesco Gelsomino, Elisa Porcellini, Mattia Riefolo, Marianna Garonzi, Paola Tononi, Sabrina Valente, Silvia Sabbioni, Francesca Fontana, Nicolò Manaresi, Antonia D’Errico, Maria A. Pantaleo, Andrea Ardizzoni, Manuela Ferracin

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Cancers of unknown primary (CUPs) comprise a heterogeneous group of rare metastatic tumors whose primary site cannot be identified after extensive clinical–pathological investigations. CUP patients are generally treated with empirical chemotherapy

Externí odkaz: https://doaj.org/article/b3542a4271e6460098eb09e62942f605

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Akademický článek

A streamlined workflow for single-cells genome-wide copy-number profiling by low-pass sequencing of LM-PCR whole-genome amplification products.

Autor: Alberto Ferrarini, Claudio Forcato, Genny Buson, Paola Tononi, Valentina Del Monaco, Mario Terracciano, Chiara Bolognesi, Francesca Fontana, Gianni Medoro, Rui Neves, Birte Möhlendick, Karim Rihawi, Andrea Ardizzoni, Semini Sumanasuriya, Penny Flohr, Maryou Lambros, Johann de Bono, Nikolas H Stoecklein, Nicolò Manaresi

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0193689 (2018)

Chromosomal instability and associated chromosomal aberrations are hallmarks of cancer and play a critical role in disease progression and development of resistance to drugs. Single-cell genome analysis has gained interest in latest years as a source

Externí odkaz: https://doaj.org/article/8c6ff371798a4662bf53ba6d47d85225

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Akademický článek

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Akademický článek

Molecular profiling of single circulating tumor cells with diagnostic intention

Publikováno v: EMBO Molecular Medicine, Vol 6, Iss 11, Pp 1371-1386 (2014)

Abstract Several hundred clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but assays are lacking for comprehensive molecular characterization of CTCs with diagnostic precision. We therefore co

Externí odkaz: https://doaj.org/article/4c7f94474173490ca4416410eb96f756

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Standardization and clinical implementation of liquid biopsy assays - IMI's CANCER-ID

Autor: Klaus Pantel, Terstappen, Leon W. M. M., nicolo manaresi, Harry J.M. Groen, Menno Tamminga, Ed Schuuring, Ellen Heitzer, Speicher, Michael R., Bjorn Naume, jon amund kyte, thomas Schlange

Publikováno v: University of Groningen
AACR annual meeting 2019

The innovative medicine initiative (IMI) project CANCER-ID (www.cancer-id.eu) is a 5 year (2014-2019) international public-private partnership of currently 40 partners from 14 countries, with the aim to evaluate technologies for Circulating Tumor Cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8abc35a24240e50f177e91692115e34b
https://research.rug.nl/en/publications/fdcac263-89c1-4091-a863-1e1d5730b9cd

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