Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicolo Bisi"'
Autor:
Luca Pinzi, Christian Conze, Nicolo Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I. Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig, Michael S. Christodoulou, Daniele Passarella, Lidia Bakota, Giulio Rastelli, Roland Brandt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Tauopathies such as Alzheimer’s disease are characterized by aggregation and increased phosphorylation of the microtubule-associated protein tau. Tau’s pathological changes are closely linked to neurodegeneration, making tau a prime cand
Externí odkaz:
https://doaj.org/article/46bfa35f5bc64145adbe0445e00ba099
Autor:
Luca Pinzi, Christian Conze, Nicolo Bisi, Gabriele Dalla Torre, Nanci Monteiro-Abreu, Nataliya I. Trushina, Ahmed Soliman, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig, Michael S. Christodoulou, Daniele Passarella, Lidia Bakota, Giulio Rastelli, Roland Brandt
Tauopathies such as Alzheimer’s disease are characterized by the aggregation and increased phosphorylation of the microtubule-associated protein tau. The pathological changes in tau are closely linked to neurodegeneration, making tau a prime candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf20f97aaeeac224a616e217be5c71f
https://doi.org/10.1101/2022.10.31.514565
https://doi.org/10.1101/2022.10.31.514565
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Traditional de novo drug discovery, which typically presents an 11% approval rate from phase I trials and even higher failure rates in fields like neurodegeneration, often requires two to three billion dollars and 10–17 years per new drug. In contr
Externí odkaz:
https://doaj.org/article/4ae91223b1ad450eb2101948e648c7b8
Autor:
Frédéric Velard, Nicolo Bisi, Janos Sapi, Sandra Audonnet, Aurélie Moniot, Stéphane Gérard, Marie Laronze-Cochard, Eric Hénon, Ingrid Allart-Simon, Miguel Ponce-Vargas
Publikováno v:
RSC Medicinal Chemistry
RSC Medicinal Chemistry, Royal Society of Chemistry, 2021, 12, pp.584-592. ⟨10.1039/d0md00423e⟩
RSC Med Chem
RSC Medicinal Chemistry, Royal Society of Chemistry, 2021, 12, pp.584-592. ⟨10.1039/d0md00423e⟩
RSC Med Chem
International audience; Cyclic nucleotide phosphodiesterase type 4 (PDE4), which controls the intracellular level of cyclic adenosine monophosphate (cAMP), has aroused scientific attention as a suitable target for antiinflammatory therapy of respirat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713631ad5f71ac378605bffc82252434
https://hal.archives-ouvertes.fr/hal-03352041
https://hal.archives-ouvertes.fr/hal-03352041
Publikováno v:
Molecules, Vol 29, Iss 3, p 722 (2024)
Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) represent two among the most frequent neurodegenerative diseases worldwide. A common hallmark of these pathologies is the misfolding and consequent aggregation of amyloid proteins into soluble
Externí odkaz:
https://doaj.org/article/3aadc38507df4468b1dc6580b9c36281
Publikováno v:
Molecules, Vol 28, Iss 11, p 4544 (2023)
Tau is a protein characterized by large structural portions displaying extended conformational changes. Unfortunately, the accumulation of this protein into toxic aggregates in neuronal cells leads to a number of severe pathologies, collectively name
Externí odkaz:
https://doaj.org/article/0e122fc5bd4d46f2b559338567e4a0b0
Autor:
Nicolò Bisi, Lucia Feni, Kaliroi Peqini, Helena Pérez-Peña, Sandrine Ongeri, Stefano Pieraccini, Sara Pellegrino
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Alpha-synuclein (αSyn) is a highly expressed and conserved protein, typically found in the presynaptic terminals of neurons. The misfolding and aggregation of αSyn into amyloid fibrils is a pathogenic hallmark of several neurodegenerative diseases
Externí odkaz:
https://doaj.org/article/e04e2c7331384a49928be9456838938c