Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nicolle H R Litjens"'
Autor:
Yen-Ling Chiu, Kai-Hsiang Shu, Feng-Jung Yang, Tzu-Ying Chou, Ping-Min Chen, Fang-Yun Lay, Szu-Yu Pan, Cheng-Jui Lin, Nicolle H R Litjens, Michiel G H Betjes, Selma Bermudez, Kung-Chi Kao, Jean-San Chia, George Wang, Yu-Sen Peng, Yi-Fang Chuang
Publikováno v:
Immunity & Ageing, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of the immune system. Nevertheless, the etiology and impact of these changes in ESRD patients remain unknown. Results Compared to healthy individuals
Externí odkaz:
https://doaj.org/article/c485f57a0a79416ea4172e2d98201066
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228096 (2020)
BACKGROUND:The hypothesis was tested that parameters of an aged T-cell compartment associate with the risk for late rejection after kidney transplantation. METHODS:Recipients of a kidney transplant in the period 2007-2013 were (N = 365) were included
Externí odkaz:
https://doaj.org/article/f7bc69d3bdf346c5aea8a2f74a28f544
Autor:
Burç Dedeoglu, Ruud W J Meijers, Mariska Klepper, Dennis A Hesselink, Carla C Baan, Nicolle H R Litjens, Michiel G H Betjes
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150826 (2016)
End-stage renal disease patients have a dysfunctional, prematurely aged peripheral T-cell system. Here we hypothesized that the degree of premature T-cell ageing before kidney transplantation predicts the risk for early acute allograft rejection (EAR
Externí odkaz:
https://doaj.org/article/1d8694267a5b45b7bfade1e593398cf2
Autor:
Nicolle H. R. Litjens, Amy C. J. van der List, Mariska Klepper, Derek Reijerkerk, Fréderique Prevoo, Michiel G. H. Betjes
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionOlder recipient age is associated with a significant decreased risk for rejection after kidney transplantation which is incompletely understood.MethodsIn a longitudinal study, circulating alloreactive T cells were assessed of young (≤45
Externí odkaz:
https://doaj.org/article/c6dee10092a64cacb8727de6e9c2b4ae
Autor:
Aafke A. Duizendstra, Michelle V. van der Grift, Patrick P. Boor, Lisanne Noordam, Robert J. de Knegt, Maikel P. Peppelenbosch, Michiel G. H. Betjes, Nicolle H. R. Litjens, Jaap Kwekkeboom
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Spontaneous operational tolerance to the allograft develops in a proportion of liver transplant (LTx) recipients weaned off immunosuppressive drugs (IS). Several previous studies have investigated whether peripheral blood gene expression profiles cou
Externí odkaz:
https://doaj.org/article/e72d1e070ca04c0287a5515d0530bf10
Autor:
Nicolle H. R. Litjens, Anton W. Langerak, Amy C. J. van der List, Mariska Klepper, Maaike de Bie, Zakia Azmani, Alexander T. den Dekker, Rutger W. W. Brouwer, Michiel G. H. Betjes, Wilfred F. J. Van IJcken
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Transcriptomics can be combined with TRA and TRB clonotype analysis at the single cell level. The aim of this study was to validate this approach on the ICELL8 Single-Cell system and to evaluate its usefulness to analyse clinical paucicellular sample
Externí odkaz:
https://doaj.org/article/306135e5e78044de8362b0971dd85cf5
Autor:
Aafke A, Duizendstra, Robert J, De Knegt, Nicole M A, Nagtzaam, Michiel G H, Betjes, Willem A, Dik, Nicolle H R, Litjens, Jaap, Kwekkeboom
Publikováno v:
Transplantation Proceedings, 54(7), 1874-1880. Elsevier Inc.
Background: Operationally tolerant liver transplant (LTx)-recipients can be weaned off immunosuppressive (IS) drugs without development of graft rejection. However, it is feared that liver fibrosis might develop after complete IS weaning. The purpose
Autor:
Nicolle H R Litjens, Amy C J van der List, Mariska Klepper, Fréderique Prevoo, Karin Boer, Dennis A Hesselink, Michiel G H Betjes
Publikováno v:
Clinical and Experimental Immunology.
Acute T-cell-mediated rejection (aTCMR) still remains a clinical problem after kidney transplantation despite significant improvements in immunosuppressive regimens. Polyfunctional T cells, i.e. T cells producing multiple pro-inflammatory cytokines,
End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8+ T Cell Subsets
Autor:
Ling Huang, Michiel G. H. Betjes, Mariska Klepper, Anton W. Langerak, Carla C. Baan, Nicolle H. R. Litjens
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease (ESRD) patients have a prematurely aged T cell system which is associated with defective T cel
Externí odkaz:
https://doaj.org/article/b88c2102b7f9445cb7c41273795be75a
Autor:
Amy C. J. van der List, Nicolle H. R. Litjens, Mariska Klepper, Fréderique Prevoo, Michiel G. H. Betjes
Publikováno v:
Journal of Immunology, 209(7), 1389-1400. American Association of Immunologists
Following kidney transplantation, donor-specific hyporesponsiveness (DSH) may develop, defined as a lowered response of alloreactive T cells, specifically directed to donor Ag. This study aimed to characterize the nature of DSH through multiparameter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85655eedd05d02a78d26e6b45b71460
https://pure.eur.nl/en/publications/ab57bfe7-828a-4425-ba60-ed771c9847fc
https://pure.eur.nl/en/publications/ab57bfe7-828a-4425-ba60-ed771c9847fc