Výsledky vyhledávání - "Nicolle F. Som"

Akademický článek

The Conserved Actinobacterial Two-Component System MtrAB Coordinates Chloramphenicol Production with Sporulation in Streptomyces venezuelae NRRL B-65442

Autor: Nicolle F. Som, Daniel Heine, Neil A. Holmes, John T. Munnoch, Govind Chandra, Ryan F. Seipke, Paul A. Hoskisson, Barrie Wilkinson, Matthew I. Hutchings

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

Streptomyces bacteria make numerous secondary metabolites, including half of all known antibiotics. Production of antibiotics is usually coordinated with the onset of sporulation but the cross regulation of these processes is not fully understood. Th

Externí odkaz: https://doaj.org/article/150e51c10e1a4f9c9bd81308b48430f2

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Sensing and responding to diverse extracellular signals: an updated analysis of the sensor kinases and response regulators of Streptomyces species

Autor: Thomas C. McLean, Matthew I. Hutchings, Mahmoud M. Al Bassam, Natalia Tschowri, Nicolle F. Som, Paul A. Hoskisson, Rebecca Lo

Publikováno v: Microbiology. 165:929-952

Streptomyces venezuelae is a Gram-positive, filamentous actinomycete with a complex developmental life cycle. Genomic analysis revealed that S. venezuelae encodes a large number of two-component systems (TCS): comprised of a membrane-bound sensor kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03af3ee01e8c5ee93d015d625d9f5133
https://doi.org/10.1099/mic.0.000817

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The MtrAB-LpqB two component system links development with secondary metabolite production in Streptomyces species and can be manipulated to switch on silent secondary metabolite clusters

Autor: Nicolle F. Som, Paul A. Hoskisson, Neil A. Holmes, John T. Munnoch, Barrie Wilkinson, Felicity Knowles, Ryan F. Seipke, Daniel Heine, Matthew I. Hutchings, Govind Chandra

Publikováno v: Access Microbiology. 1

Streptomyces species are important producers of bioactive compounds such as antibiotics, antitumor and immunosuppressant drugs. Around two-thirds of all known natural antibiotics are produced by these bacteria and antibiotic production is linked to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f655c1f8870d555f0519a16c803e3f91
https://doi.org/10.1099/acmi.ac2019.po0054

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Deciphering the regulatory mechanisms of formicamycin biosynthesis in Streptomyces formicae, a novel antibiotic against MRSA

Autor: Nicolle F. Som, Matthew I. Hutchings, Rebecca Devine, Katherine Noble

Publikováno v: Access Microbiology. 1

Derivatives of the secondary metabolites of Streptomyces bacteria account for over half of the antibiotics currently used in the clinic. A crucial part of overcoming antimicrobial resistance (AMR) is in the development of new antibiotics that functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4724b7cb79655d338da0d4396dd75582
https://doi.org/10.1099/acmi.ac2019.po0332

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MtrA is an essential regulator that coordinates antibiotic production and sporulation in Streptomyces species

Autor: Felicity Knowles, Govind Chandra, John T. Munnoch, Matthew I. Hutchings, Neil A. Holmes, Ryan F. Seipke, Barrie Wilkinson, Nicolle F. Som, Paul A. Hoskisson, Daniel Heine

Streptomyces bacteria make numerous secondary metabolites, including half of all known antibiotics. Understanding the global regulation of secondary metabolism is important because most Streptomyces natural products are not made under laboratory cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80143d40d3002772f1324f2782c13080
https://doi.org/10.1101/090399

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