Výsledky vyhledávání - "Nicolle, Platt"

Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling

Autor: Yasmim de Oliveira Dalsenter, Morgana Moretti, Mauren K. Tavares, Priscila B. Rosa, Ana Lúcia S. Rodrigues, Daiane B. Fraga, Isabella A. Heinrich, Fernanda Neutzling Kaufmann, Luis E.B. Bettio, Vivian B. Neis, Andiara E. Freitas, Rodrigo B. Leal, Nicolle Platt, Isabel Werle, Axel Fogaça Rosado

Publikováno v: Purinergic Signal

Guanosine is a purine nucleoside that has been shown to exhibit antidepressant effects, but the mechanisms underlying its effect are not well established. We investigated if the antidepressant-like effect induced by guanosine in the tail suspension t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260dfd9b576f53d13dbf3d65b85d5b61
https://doi.org/10.1007/s11302-021-09779-6

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Involvement of serotonergic neurotransmission in the antidepressant-like effect elicited by cholecalciferol in the chronic unpredictable stress model in mice

Autor: Vivian B, Neis, Isabel, Werle, Morgana, Moretti, Priscila B, Rosa, Anderson, Camargo, Yasmim, de O Dalsenter, Nicolle, Platt, Axel F, Rosado, William D, Engel, Gudrian Ricardo L, de Almeida, Ingrid, Selhorst, Alcir Luiz, Dafre, Ana Lúcia S, Rodrigues

Publikováno v: Metabolic brain disease. 37(5)

Cholecalciferol deficiency has been associated with stress-related psychiatric disorders, particularly depression. Therefore, the present study investigated the antidepressant-like effect of cholecalciferol in female mice and the possible role of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::475e937f86f82166271777db17764c05
https://pubmed.ncbi.nlm.nih.gov/35435610

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Cholecalciferol abolishes depressive-like behavior and hippocampal glucocorticoid receptor impairment induced by chronic corticosterone administration in mice

Autor: Ana Lúcia Bertarello Zeni, Ana Lúcia S. Rodrigues, Ana Paula Dalmagro, Nicolle Platt, Vivian B. Neis, Anderson Camargo, Manuella P. Kaster, Axel Fogaça Rosado

Publikováno v: Pharmacology, biochemistry, and behavior. 196

Several attempts have been made to understand the role of cholecalciferol (vitamin D3) in the modulation of neuropsychiatric disorders. Notably, the deficiency of vitamin D3 is considered a pandemic and has been postulated to enhance the risk of majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd75f8ef70527a15b7f4a6498900f00
https://pubmed.ncbi.nlm.nih.gov/32585162

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Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway

Autor: Isabella A. Heinrich, Andiara E. Freitas, Mauren K. Tavares, Manuella P. Kaster, Ingrid A.V. Wolin, Rodrigo B. Leal, Suellen dos Reis, Ana Lúcia S. Rodrigues, Nicolle Platt

Publikováno v: Neurochemistry International. 118:275-285

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is one of the most robust neurobiological findings in the pathophysiology of major depressive disorder (MDD) over the last 40 years. The persistent increase in glucocorticoids levels indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d49b3c875117599218163a6e36020c
https://doi.org/10.1016/j.neuint.2018.05.006

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Depression and peripheral inflammatory profile of patients with obesity

Autor: Débora Kurrle Rieger, Ana Lúcia S. Rodrigues, Fernanda Neutzling Kaufmann, Gabriela Ambrósio, Manuella P. Kaster, Luana M. Manosso, Gabriele Ghisleni, Nicolle Platt

Publikováno v: Psychoneuroendocrinology. 91:132-141

This narrative review will present and discuss clinical data from 16 cross-sectional and 6 longitudinal studies examining the relationship between body mass index (BMI), symptoms of depression and peripheral inflammation. Our aim is to determine whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b344c837e5b9280c4a0d8c1f191a5739
https://doi.org/10.1016/j.psyneuen.2018.03.005

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Protective Effects of Ursolic Acid Against Cytotoxicity Induced by Corticosterone: Role of Protein Kinases

Autor: Isabella A. Heinrich, Manuella P. Kaster, Andiara E. Freitas, Rodrigo B. Leal, Nicolle Platt, Ana Lúcia S. Rodrigues, Manuela G. López, Ana B. Ramos-Hryb

Publikováno v: Neurochemical research.

Neuronal hippocampal death can be induced by exacerbated levels of cortisol, a condition usually observed in patients with Major depressive disorder (MDD). Previous in vitro and in vivo studies showed that ursolic acid (UA) elicits antidepressant and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3aef84009528182d5ab185374645d90
https://pubmed.ncbi.nlm.nih.gov/31713091

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A single coadministration of subeffective doses of ascorbic acid and ketamine reverses the depressive-like behavior induced by chronic unpredictable stress in mice

Autor: Isabel Werle, Priscila B. Rosa, Suene Vanessa da Silva Souza, Morgana Moretti, Vivian B. Neis, Ana Lúcia S. Rodrigues, Nicolle Platt

Publikováno v: Pharmacology, biochemistry, and behavior. 187

In this study, we investigated the ability of a single coadministration of subeffective doses of ascorbic acid and ketamine to reverse the depressive-like behavior induced by chronic unpredictable stress (CUS) in mice. Moreover, we examined the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2333763dc9ea3d7df7267e9e5aa876d8
https://pubmed.ncbi.nlm.nih.gov/31678791

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O papel da neuroinflamação nas alterações comportamentais e neuroquímicas induzidas pelo estresse precoce

Autor: Santos, Nicolle Platt dos

Publikováno v: Repositório Institucional da UFSC
Universidade Federal de Santa Catarina (UFSC)
instacron:UFSC

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2019. O estresse é uma resposta adaptativa que realiza mudanças fisiológicas necessár

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::02cfe8eb99b12ff452686d389a12bd72
https://repositorio.ufsc.br/handle/123456789/215622

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The involvement of PI3K/Akt/mTOR/GSK3β signaling pathways in the antidepressant-like effect of AZD6765

Autor: Priscila B. Rosa, Axel Fogaça Rosado, Isabel Werle, Morgana Moretti, Ana Lúcia S. Rodrigues, Vivian B. Neis, Fernanda Neutzling Kaufmann, Yasmim de Oliveira Dalsenter, Matheus Henrique Besen, Nicolle Platt

Publikováno v: Pharmacology Biochemistry and Behavior. 198:173020

AZD6765 (lanicemine) is a non-competitive NMDA receptor antagonist that induces a fast-acting antidepressant effect without presenting psychotomimetic effects. However, the mechanisms underlying its effects remain to be established. In this context,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd21256e626ec15cc0ca9d6f25b48641
https://doi.org/10.1016/j.pbb.2020.173020

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