Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling

Autor: Shelia Govind, Pierre Olivier Lang, Alexander Bürkle, María Moreno-Villanueva, Claudio Franceschi, Miriam Capri, Jurgen Bernard, Birgit Weinberger, Beatrix Grubeck-Loebenstein, Simone Fiegl, Efstathios S. Gonos, Ewa Sikora, Eugène Jansen, Martijn E. T. Dollé, Tilman Grune, Nicolle Breusing, Richard Aspinall

Publikováno v: Immunity & Ageing, Vol 21, Iss 1, Pp 1-12 (2024)

Abstract Decline in immune function with age has been studied extensively, but approaches to immune restoration have been hampered by the lack of simple methods of identifying individuals whose immune system is in decline. Our approach has been to id

Externí odkaz: https://doaj.org/article/312250a0783f4d4ab133860b37146370

Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study

Autor: Patrizia D’Aquila, Robertina Giacconi, Marco Malavolta, Francesco Piacenza, Alexander Bürkle, María Moreno Villanueva, Martijn E. T. Dollé, Eugène Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Antti Hervonen, Mikko Hurme, P. Eline Slagboom, Christiane Schön, Jürgen Bernhardt, Nicolle Breusing, Giuseppe Passarino, Mauro Provinciali, Dina Bellizzi

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

The presence of circulating microbiome in blood has been reported in both physiological and pathological conditions, although its origins, identities and function remain to be elucidated. This study aimed to investigate the presence of blood microbio

Externí odkaz: https://doaj.org/article/4e861e7abb794ca3a368b39764b890dd

Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics

Autor: Laura Kananen, Mikko Hurme, Alexander Bürkle, Maria Moreno-Villanueva, Jürgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dollé, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Härkänen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimäki, Olli T. Raitakari, Olavi Ukkola, Mika Kähönen, Marja Jylhä, Juulia Jylhävä

Publikováno v: GEROSCIENCE
Kananen, L, Hurme, M, Bürkle, A, Moreno-Villanueva, M, Bernhardt, J, Debacq-Chainiaux, F, Grubeck-Loebenstein, B, Malavolta, M, Basso, A, Piacenza, F, Collino, S, Gonos, E S, Sikora, E, Gradinaru, D, Jansen, E H J M, Dollé, M E T, Salmon, M, Stuetz, W, Weber, D, Grune, T, Breusing, N, Simm, A, Capri, M, Franceschi, C, Slagboom, E, Talbot, D, Libert, C, Raitanen, J, Koskinen, S, Härkänen, T, Stenholm, S, Ala-Korpela, M, Lehtimäki, T, Raitakari, O T, Ukkola, O, Kähönen, M, Jylhä, M & Jylhävä, J 2022, ' Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics ', GeroScience, vol. 45, no. 1, pp. 85-103 . https://doi.org/10.1007/s11357-022-00590-8

Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes and metabolic processes that lead to elevated cf-DNA levels. We so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1937b684e94cf6fd814da6a2766df5
https://biblio.ugent.be/publication/01H3MEVG6Y0Y2FEYN73BRTMM0J/file/01H3MEYCVHDKPXJFS8FDX6YT26

Bacterial DNAemia in older participants and nonagenarian offspring and association with redox biomarkers

Autor: Robertina Giacconi, Patrizia D’Aquila, Marco Malavolta, Francesco Piacenza, Alexander Bürkle, María Moreno Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Efstathios S Gonos, Claudio Franceschi, Miriam Capri, Daniela Gradinaru, Beatrix Grubeck-Loebenstein, Ewa Sikora, Wolfgang Stuetz, Daniela Weber, Olivier Toussaint, Florence Debacq-Chainiaux, Antti Hervonen, Mikko Hurme, P Eline Slagboom, Christiane Schön, Jürgen Bernhardt, Nicolle Breusing, Talbot Duncan, Giuseppe Passarino, Dina Bellizzi, Mauro Provinciali

Publikováno v: The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 78(1), 42-50. OXFORD UNIV PRESS INC

Aging and age-related diseases have been linked to microbial dysbiosis with changes in blood bacterial DNA concentration. This condition may promote chronic low-grade inflammation, which can be further aggravated by antioxidant nutrient deficiency. L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f74d4ac70e929d71d2a4a668ec2c216
https://hdl.handle.net/1887/3562128

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

Autor: Martijn E.T. Dollé, Albert Wong, W M Monique Verschuren, Nicolle Breusing, Beatrix Grubeck-Loebenstein, Francesco Piacenza, Florence Debacq-Chainiaux, Efstathios S. Gonos, Andrea Basso, P. Eline Slagboom, Wolfgang Stuetz, Eugène H.J.M. Jansen, Maria Moreno-Villanueva, Tilman Grune, M. Liset Rietman, Alexander Bürkle, Jürgen Bernhardt, Annemieke M.W. Spijkerman, Harry van Steeg, Thilo Sindlinger, Claudio Franceschi, Marco Malavolta, Sebastiano Collino, Daniela Weber, Olivier Toussaint, Ewa Sikora

Publikováno v: Mechanisms of Ageing and Development, 177, 135. Elsevier Ireland Ltd

Frailty among elderly people leads to an increased risk for negative health outcomes. To prevent frailty, we need a better understanding of the underlying mechanisms and early detection of individuals at risk. Both may be served by identifying candid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed12b8c1e8e6baa496c7b0939055f31
https://doi.org/10.1016/j.mad.2018.04.007