Impact of ancestral sequence reconstruction on mechanistic and structural enzymology

Autor: Nicoll, Callum R., Massari, Marta, Fraaije, Marco W., Mascotti, Maria Laura, Mattevi, Andrea

Publikováno v: In Current Opinion in Structural Biology October 2023 82

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Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties

Autor: Bailleul, Gautier, Nicoll, Callum R., Mascotti, María Laura, Mattevi, Andrea, Fraaije, Marco W.

Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry, 296:100221. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The Journal of Biological Chemistry

Mammals rely on the oxidative flavin-containing monooxygenases (FMOs) to detoxify numerous and potentially deleterious xenobiotics; this activity extends to many drugs, giving FMOs high pharmacological relevance. However, our knowledge regarding thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d45dc686c62d7c552ab1bdca20fa61

Formation of a Copper(II)–Tyrosyl Complex at the Active Site of Lytic Polysaccharide Monooxygenases Following Oxidation by H2O2

Autor: Paradisi, Alessandro, Johnston, Esther M., Tovborg, Morten, Nicoll, Callum R., Ciano, Luisa, Dowle, Adam, McMaster, Jonathan, Hancock, Y., Davies, Gideon J., Walton, Paul H.

Hydrogen peroxide is a cosubstrate for the oxidative cleavage of saccharidic substrates by copper-containing lytic polysaccharide monooxygenases (LPMOs). The rate of reaction of LPMOs with hydrogen peroxide is high, but it is accompanied by rapid ina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d98d0884df16c7c747838c0f3a70f324

Formation of a Copper(II)–Tyrosyl Complex at the Active Site of Lytic Polysaccharide Monooxygenases Following Oxidation by H2O2.

Autor: Paradisi, Alessandro, Johnston, Esther M., Tovborg, Morten, Nicoll, Callum R., Ciano, Luisa, Dowle, Adam, McMaster, Jonathan, Hancock, Y., Davies, Gideon J., Walton, Paul H.

Publikováno v: Journal of the American Chemical Society; 11/20/2019, Vol. 141 Issue 46, p18585-18599, 15p