Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicoline Videbæk"'
Autor:
Dorte Bjerre Steensgaard, Jesper Søndergaard Marino, Lotte T Spang, Arne Staby, Nicoline Videbæk, Christina Bartholdy, Heidrun Bosch-Traberg, Kim F. Haselmann, Désirée J Asgreen, Ole Schelde
Publikováno v:
Pharmaceutical Research. 37
Purpose Manufacturing processes for polypeptide/protein drugs are designed to ensure robust quality, efficacy and safety. Process differences introduced by follow-on manufacturers may result in changes in quality and clinical outcomes. This study inv
Autor:
Jens J. Holst, Wolfgang E. Schmidt, Michael A. Nauck, Julio Rosenstock, Nicoline Videbæk, John B. Buse, Jason Brett, Alan M. Garber
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:1695-1702
Therapeutic proteins/peptides can produce immunogenic responses that may increase the risk of adverse events or reduce efficacy.The objectives were to measure and characterize antibody formation to liraglutide, a glucagon-like peptide-1 receptor agon
Publikováno v:
DNA Sequence. 11:485-499
GAD65 and GAD67 are two isoforms of the enzyme glutamic acid decarboxylase which catalyze the production of GABA from glutamate, primarily in the brain. However, GAD and GABA also prevail in the retina, testes and islets of Langerhans. The main funct
Autor:
Niels Blume, Jacob S. Petersen, Tina B. Rambrandt, Birgitte K. Michelsen, Esper Boel, Nicoline Videbæk, Allan E. Karlsen, Ole D. Madsen
Publikováno v:
Biochemical Society Transactions. 21:173-177
Autor:
Urs Christen, Anne Cooke, Matthias von Herrath, Mette Ejrnaes, Birgitte K. Michelsen, Nicoline Videbæk
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 174(5)
Type 1 diabetes mellitus is an autoimmune disease characterized by T cell-mediated destruction of the insulin-producing β cells in the islets of Langerhans. From studies in animal models, CD8+ T cells recognizing autoantigens such as islet-specific
Autor:
Jenny M. Phillips, Birgitte K. Michelsen, Patricia R. Hutchings, Anne Cooke, Silvia Zusman Harach, Nicoline Videbæk, Patricia Ozegbe
Publikováno v:
Journal of autoimmunity. 20(2)
T cells play a central role in the development of diabetes both in man and in the non-obese diabetic (NOD) mouse. Both the CD4(+) and CD8(+) subsets of T cells are required for the normal development of IDDM in NOD mice. Islet reactive CD4(+) T cells
Autor:
Helle Vestergaard Petersen, Birgitte K. Michelsen, Nicoline Videbæk, Kresten Skak, Anette A. Pedersen
Publikováno v:
Biochemical and biophysical research communications. 295(2)
Glucose responsiveness is a fundamental metabolic feature of pancreatic β-cells. Glucose-regulated transcription of the insulin gene is in part mediated via the homeobox transcription factor PDX-1. Another islet protein and diabetes autoantigen, glu