Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicoline Treijtel"'
Autor:
Salma Assil, Thomas P. Buters, Pieter W. Hameeteman, Charlie Hallard, Nicoline Treijtel, Tessa Niemeyer – Van der Kolk, Marieke L. de Kam, Edwin F. I. I. I. Florencia, Errol P. Prens, Martijn B. A. van Doorn, Robert Rissmann, Naomi B. Klarenbeek, Manon A. A. Jansen, Matthijs Moerland
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Imiquimod (IMQ) is a topical agent that induces local inflammation via the Toll-like receptor 7 pathway. Recently, an IMQ-driven skin inflammation model was developed in healthy volunteers for proof-of-pharmacology trials. The aim of this study was t
Externí odkaz:
https://doaj.org/article/f03a8555dda44e0c8f9b4a37d47243ce
Autor:
Laura M. de Jong, Sylvia D. Klomp, Nicoline Treijtel, Robert Rissmann, Jesse J. Swen, Martijn L. Manson
Publikováno v:
British Journal of Clinical Pharmacology, 88(10), 4387-4402
British Journal of Clinical Pharmacology, 88(10), 4387-4402. WILEY
British Journal of Clinical Pharmacology, 88(10), 4387-4402. WILEY
Aim: Use of immunomodulating therapeutics for immune-mediated inflammatory diseases may cause disease-drug-drug interactions (DDDIs) by reversing inflammation-driven alterations in the metabolic capacity of cytochrome P450 enzymes. European Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93343a4a2817e269defa8b78634b35e9
https://hdl.handle.net/1887/3483880
https://hdl.handle.net/1887/3483880
Autor:
Michel van Bruijnsvoort, Rainard Fuhr, Etienne Ernault, Christiane Collins, Nicoline Treijtel, Paul Passier, Shanti Gangaram-Panday
Publikováno v:
Clinical Pharmacology in Drug Development
ASP8477 (molecular weight 325.36 g/mol) is a fatty acid amide hydrolase inhibitor intended for the treatment of neuropathic pain. Results from in vitro studies indicated that ASP8477 is a direct inhibitor of cytochrome P450 (CYP) 2C8, 2C9, 2C19, 2D6,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57013d333272ee013a831d9a490e992a
https://doi.org/10.1002/cpdd.660
https://doi.org/10.1002/cpdd.660
Autor:
Dorien Groenendaal-van de Meent, Cees Korstanje, Klaus Francke, Michiel de Vries, John Meijer, Nicoline Treijtel, Matthias Grossmann, Ingrid Michon
Publikováno v:
Clinical pharmacology in drug developmentReferences. 11(1)
Pilocarpine-induced salivary secretion could serve as a nontherapeutic target engagement biomarker in a clinical setting to test the activity of an M3 positive allosteric modulator (PAM). The potentiating effect on the reactivity of the M3 receptor t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a314053525a1c266450dc6f659c8dbf8
https://pubmed.ncbi.nlm.nih.gov/34826362
https://pubmed.ncbi.nlm.nih.gov/34826362
Autor:
Nicoline Treijtel, Arjan Barendregt, Andreas P. Freidig, Bas J. Blaauboer, Jan C. H. van Eijkeren
Publikováno v:
Drug Metabolism and Disposition. 32:884-891
An alternative approach is introduced in determining the in vitro intrinsic clearance of slowly metabolized compounds. The longterm sandwich rat hepatocyte culture was exploited, allowing for sufficient substrate depletion to obtain a reliable cleara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3109dc8317454d8a8f7fe03d81cde9e
https://doi.org/10.1124/dmd.32.8.884
https://doi.org/10.1124/dmd.32.8.884
Autor:
Josy M. Gubbens-Stibbe, Nicoline Treijtel, Lambertus A. Peletier, Piet H. van der Graaf, Meindert Danhof, Klaas P. Zuideveld, Hugo J. Maas
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:330-338
The objective of this investigation was to characterize quantitatively the pharmacodynamic interaction between N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide (WAY-100,635) and R-(+)-8-hydroxy-2-(di-n-propylamino)t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7bdbf385183504ee6b8f7b86818ffb
https://doi.org/10.1124/jpet.300.1.330
https://doi.org/10.1124/jpet.300.1.330
Autor:
Piet H. van der Graaf, Hugo J. Maas, Meindert Danhof, Klaas P. Zuideveld, Lambertus A. Peletier, Nicoline Treijtel, Joost Hulshof
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 281:R2059-R2071
Agonists for the 5-hydroxytryptamine (HT)1Areceptor induce a hypothermic response that is believed to occur by lowering of the body's set-point temperature. We have developed a physiological model that can be used to predict the complex time course o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3079a2122ae3dd0af101d0cc9930ee5d
https://doi.org/10.1152/ajpregu.2001.281.6.r2059
https://doi.org/10.1152/ajpregu.2001.281.6.r2059
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 738:67-73
A rapid, sensitive and enantioselective HPLC assay for the simultaneous determination of the reference 5-HT1A receptor agonists, R-(+)- and S-(-)-8-hydroxy-2-(di-n-propylamino)tetralin (R-8-OH-DPAT and S-8-OH-DPAT, respectively), in rat blood is pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c217b348318e991f7720399130f2fd
https://doi.org/10.1016/s0378-4347(99)00493-4
https://doi.org/10.1016/s0378-4347(99)00493-4
Autor:
J.C.H. van Eijkeren, Nicoline Treijtel, Andreas P. Freidig, I.C.J. de Greef-van der Sandt, Sandra M. Nijmeijer
Publikováno v:
Toxicology in Vitro, 1, 23, 185-193
The metabolism and active transport of ritonavir and saquinavir were studied using sandwich-cultured rat hepatoyctes and rat liver microsomes. For ritonavir four comparable metabolites were observed in the sandwich-culture and in microsomes. For saqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8e797c3b1e2aa2d75fcce51877b90c
http://resolver.tudelft.nl/uuid:be67a180-ed93-458c-ab25-a3aaaa1d9950
http://resolver.tudelft.nl/uuid:be67a180-ed93-458c-ab25-a3aaaa1d9950
Autor:
Nicoline Treijtel, Arjan Barendregt, Bas J. Blaauboer, Hanneke van Helvoort, Jan C. H. van Eijkeren
Publikováno v:
Drug Metabolism and Disposition, 33, 9, pp. 1325-32
Drug Metabolism and Disposition, 33, 1325-32
Drug Metabolism and Disposition, 33, 1325-32
Item does not contain fulltext The application of sandwich-cultured rat hepatocytes for the identification of the hepatic intrinsic clearance of compounds with widely varying extraction ratios was investigated. We previously showed the applicability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfa6186648165b71241b5f1c37b53ce
https://hdl.handle.net/2066/47434
https://hdl.handle.net/2066/47434