Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Nicolin Bloch"'
Autor:
Eric C Logue, Nicolin Bloch, Erica Dhuey, Ruonan Zhang, Ping Cao, Cecile Herate, Lise Chauveau, Stevan R Hubbard, Nathaniel R Landau
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97062 (2014)
APOBEC3A (A3A), one of the seven-member APOBEC3 family of cytidine deaminases, lacks strong antiviral activity against lentiviruses but is a potent inhibitor of adeno-associated virus and endogenous retroelements. In this report, we characterize the
Externí odkaz:
https://doaj.org/article/c4e98eb74fb7470498c195b84b4cddac
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89558 (2014)
SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4(+) T cells and that is counteracted in SIV and HIV-2 by the Vpx accessory protein. The protein is a phosphohydrolase that lowers the concentration of de
Externí odkaz:
https://doaj.org/article/9d1b9dfe10ea42ff909ab0337e5a8f78
Autor:
Susan C. Irvin, Amanda D’Orvilliers, Nicolin Bloch, Kayla Boccio, Jason Pennucci, Jurriaan Brouwer-Visser, Erica Ullman, Manoj Rajadhyaksha, Mohamed Hassanein, Terra Potocky, Albert Torri, Aynur Hermann, Michael A. Partridge
Publikováno v:
The AAPS journal. 24(4)
A cell-based assay was developed to detect neutralizing anti-drug antibodies (NAbs) against odronextamab, a CD20xCD3 bispecific monoclonal antibody (mAb) under investigation for treatment of CD20+ B cell malignancies. In this assay, odronextamab brid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba4d639ae9bc3d0c9c37fff3850451e
https://pubmed.ncbi.nlm.nih.gov/35725847
https://pubmed.ncbi.nlm.nih.gov/35725847
Publikováno v:
Nature Immunology. 16:546-553
To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell, co-opting mechanisms of cellular physiology while defeating restriction factors that are dedicated to halting their progression. Primate lentiviruses devote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b812bc0e7c12d2352a1e9ad3e6498e
https://doi.org/10.1038/ni.3156
https://doi.org/10.1038/ni.3156
Publikováno v:
Retrovirology
Background Monocytes, the primary myeloid cell-type in peripheral blood, are resistant to HIV-1 infection as a result of the lentiviral restriction factor SAMHD1. Toll-like receptors recognize microbial pathogen components, inducing the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36aa0de6f294f202ece01ce0d55f07eb
http://europepmc.org/articles/PMC5131500
http://europepmc.org/articles/PMC5131500
Autor:
Megan L. Schultz, Sylvie B. Polsky, Waaqo Daddacha, Baek Kim, Nathaniel R. Landau, Henning Hofmann, Nicolin Bloch, Eric C. Logue
Publikováno v:
Journal of Virology. 86:12552-12560
Sterile alpha motif domain- and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase that restricts the replication of lentiviruses in myeloid cells by hydrolyzing the cellular deoxynucleotide triphosphates to a level belo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07251b3bc1504ef1379d85cf5c74b8b7
https://doi.org/10.1128/jvi.01657-12
https://doi.org/10.1128/jvi.01657-12
Autor:
Baek Kim, Henning Hofmann, Sabine Gläsker, Nicolin Bloch, Poojitha Sitaram, Nathaniel R. Landau, Caitlin Shepard, Megan L. Schultz
Publikováno v:
The Journal of biological chemistry. 292(3)
The triphosphohydrolase SAMHD1 (sterile α motif and histidine-aspartate domain-containing protein 1) restricts HIV-1 replication in nondividing myeloid cells by depleting the dNTP pool, preventing reverse transcription. SAMHD1 is also reported to ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a09c7615eab80b1c5f93ce7ce2d6985
https://pubmed.ncbi.nlm.nih.gov/27920203
https://pubmed.ncbi.nlm.nih.gov/27920203
Autor:
Anthony D. Lucas, Nicolin Bloch, Yee Tsuey Ong, Nathaniel R. Landau, Maritza Puray-Chavez, Eleftherios Michailidis, Stefan G. Sarafianos, Andrew D. Huber, Megan L. Schultz, Maxwell D. Leslie, Karen A. Kirby, Juan Ji
Sterile alpha motif- and histidine/aspartic acid domain-containing protein 1 (SAMHD1) limits HIV-1 replication by hydrolyzing deoxynucleoside triphosphates (dNTPs) necessary for reverse transcription. Nucleoside reverse transcriptase inhibitors (NRTI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca44fbfe5ae1bc82960be94ff6468b0
https://europepmc.org/articles/PMC4136039/
https://europepmc.org/articles/PMC4136039/
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e89558 (2014)
PLoS ONE, Vol 9, Iss 2, p e89558 (2014)
SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4(+) T cells and that is counteracted in SIV and HIV-2 by the Vpx accessory protein. The protein is a phosphohydrolase that lowers the concentration of de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7f8a68398e0f1c33492d87487be98a
http://europepmc.org/articles/PMC3929709
http://europepmc.org/articles/PMC3929709
Autor:
Nathaniel R. Landau, Thomas D. Norton, Sylvie B. Polsky, Nina Bhardwaj, Meagan O’Brien, Nicolin Bloch
Publikováno v:
AIDS research and human retroviruses. 30(2)
Dendritic cells are professional antigen-presenting cells of the immune system and are major producers of type-I interferon. Their role in HIV-1 infection is not well understood. They express CD4 and CCR5 yet appear to be resistant to infection. In c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7c112afb6e62240080598666ff20e6
https://pubmed.ncbi.nlm.nih.gov/23924154
https://pubmed.ncbi.nlm.nih.gov/23924154