Výsledky vyhledávání - "Nicolette Ocampo"

Polyamine Transport Inhibitors: Design, Synthesis, and Combination Therapies with Difluoromethylornithine

Autor: Meenu Madan, Jennifer Archer, Nicolette Ocampo, Aaron Muth, Otto Phanstiel, Luis Rodríguez

Publikováno v: Journal of Medicinal Chemistry. 57:348-363

The development of polyamine transport inhibitors (PTIs), in combination with the polyamine biosynthesis inhibitor difluoromethylornithine (DFMO), provides a method to target cancers with high polyamine requirements. The DFMO+PTI combination therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecafe17c969661ea2691981776c1919
https://doi.org/10.1021/jm401174a

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Development of flavonoid-based inverse agonists of the key signaling receptor US28 of human cytomegalovirus

Autor: Markus R. Heinrich, Mai-Thao Nguyen, Nicolette Ocampo, Otto Phanstiel, Quinto Gesiotto, Ana Kralj, Nuska Tschammer

Publikováno v: Journal of medicinal chemistry. 56(12)

A series of 31 chalcone- and flavonoid-based derivatives were synthesized in good overall yields and screened for their inverse agonist activity on the US28 receptor of human cytomegalovirus (HCMV). With one exception (e.g., 2-(5-bromo-2-methoxypheny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232aa22cbfd7cfe5d4c14295ad99fdc8
https://pubmed.ncbi.nlm.nih.gov/23768434

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