Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nicoletta Pons"'
Publikováno v:
Rapid Communications in Mass Spectrometry. 20:1209-1217
Bilirubin is a protective antioxidant; however, when its conjugation and excretion are impaired, as in neonatal and hereditary jaundice, bilirubin accumulates and may cause severe neurotoxicity. Degradation of bilirubin takes place (a) on interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda8092d784a3c57eb62d6200cb972b7
https://doi.org/10.1002/rcm.2431
https://doi.org/10.1002/rcm.2431
Publikováno v:
Food and Chemical Toxicology. 42:785-790
Three chromogenic products of AHTN have been detected after photo-oxidation and shown to react with glycine or albumin, giving rise first to a blue color, followed by pink and, finally, a dark green colour. The absorption spectrum associated with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd063985a44fd880d3bb8007f91ceeb
https://doi.org/10.1016/j.fct.2003.09.012
https://doi.org/10.1016/j.fct.2003.09.012
Publikováno v:
Biochemical Pharmacology. 66:405-414
Polyhalogenated compounds, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, are associated with toxic Uroporphyria and cause alleviation of jaundice in the Gunn rat. These effects have been attributed to a microsomal oxidation of uroporphyrinogen and bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5696d08261069f90415d0e2c370f2e46
https://doi.org/10.1016/s0006-2952(03)00284-3
https://doi.org/10.1016/s0006-2952(03)00284-3
Publikováno v:
Biochemical Pharmacology. 63:615-624
In previous work it was shown that hepatic microsomes from rats treated with 3-methylcholanthrene and similar inducers had increased bilirubin-degrading activity. The activity was further stimulated by addition of 3,4-tetrachlorobiphenyl (TCB), a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f1ce3a85cc2d242f4cb6caa961520a7
https://doi.org/10.1016/s0006-2952(01)00851-6
https://doi.org/10.1016/s0006-2952(01)00851-6
Autor:
Konstantine W. Skordos, Grant T. Generaux, Christopher MacLauchlin, Nicoletta Pons, Jackie C. Bloomer, Carole Shardlow
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 39(11)
Several reports in the literature present the utility and value of in vitro drug-metabolizing enzyme inhibition data to predict in vivo drug-drug interactions in humans. A retrospective analysis has been conducted for 26 GlaxoSmithKline (GSK) drugs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4718e3bc95e4ef9a40bb81551168c2
https://pubmed.ncbi.nlm.nih.gov/21832001
https://pubmed.ncbi.nlm.nih.gov/21832001
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 39(3)
Casopitant [1-piperidinecarboxamide,4-(4-acetyl-1-piperazinyl)-N-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-(2R,4S), GW679769] has previously been shown to be a potent and selective antagonist of the human ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b54b063b7bfbcd4d877139a33edde43
https://pubmed.ncbi.nlm.nih.gov/21149541
https://pubmed.ncbi.nlm.nih.gov/21149541
Autor:
Riccarda Granata, Ezio Ghigo, Nicoletta Pons, Filomena Catapano, Giampiero Muccioli, Corrado Ghè
Publikováno v:
European journal of pharmacology. 498(1-3)
Besides possessing a strong growth hormone (GH)-releasing activity, the gastrointestinal octanoylated peptide ghrelin has been reported to antagonize lipolysis in rat adipocytes. It is not yet clear whether this inhibitory activity on lipolysis is al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f555800fb1d028753fb0ddb085249d95
https://pubmed.ncbi.nlm.nih.gov/15363972
https://pubmed.ncbi.nlm.nih.gov/15363972
Publikováno v:
Biochemical pharmacology. 66(3)
Polyhalogenated compounds, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, are associated with toxic Uroporphyria and cause alleviation of jaundice in the Gunn rat. These effects have been attributed to a microsomal oxidation of uroporphyrinogen and bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16df62a2597709bfad05fd94ccb7ca81
https://pubmed.ncbi.nlm.nih.gov/12907239
https://pubmed.ncbi.nlm.nih.gov/12907239
Publikováno v:
Biochemical pharmacology. 63(4)
In previous work it was shown that hepatic microsomes from rats treated with 3-methylcholanthrene and similar inducers had increased bilirubin-degrading activity. The activity was further stimulated by addition of 3,4-tetrachlorobiphenyl (TCB), a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8d7c1f7f90c70a9be2370f546d84b7c
https://pubmed.ncbi.nlm.nih.gov/11992629
https://pubmed.ncbi.nlm.nih.gov/11992629