Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells

Autor: Jérémy Dufloo, Cyril Planchais, Stéphane Frémont, Valérie Lorin, Florence Guivel-Benhassine, Karl Stefic, Nicoletta Casartelli, Arnaud Echard, Philippe Roingeard, Hugo Mouquet, Olivier Schwartz, Timothée Bruel

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Broadly neutralizing antibodies (bNAbs) neutralize HIV-1 and exert Fc-dependent activities against infected cells. Here, Dufloo et al. show that bNAbs also block HIV-1 release by trapping viral particles at the surface of infected cells.

Externí odkaz: https://doaj.org/article/977bb085667e46c7b122b4a7032ff1fb

Elimination of HIV-1-infected cells by broadly neutralizing antibodies

Autor: Timothée Bruel, Florence Guivel-Benhassine, Sonia Amraoui, Marine Malbec, Léa Richard, Katia Bourdic, Daniel Aaron Donahue, Valérie Lorin, Nicoletta Casartelli, Nicolas Noël, Olivier Lambotte, Hugo Mouquet, Olivier Schwartz

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

Broadly neutralizing antibodies (bNAbs) are promising as potential therapies targeting HIV-1 but their overall antiviral activity remains to be fully elucidated. Here the authors evaluate the ability of a panel of bNAbs to trigger antibody-dependent

Externí odkaz: https://doaj.org/article/0c92443559f14621a72a3877677ac63a

Tetherin restricts productive HIV-1 cell-to-cell transmission.

Autor: Nicoletta Casartelli, Marion Sourisseau, Jerome Feldmann, Florence Guivel-Benhassine, Adeline Mallet, Anne-Geneviève Marcelin, John Guatelli, Olivier Schwartz

Publikováno v: PLoS Pathogens, Vol 6, Iss 6, p e1000955 (2010)

The IFN-inducible antiviral protein tetherin (or BST-2/CD317/HM1.24) impairs release of mature HIV-1 particles from infected cells. HIV-1 Vpu antagonizes the effect of tetherin. The fate of virions trapped at the cell surface remains poorly understoo

Externí odkaz: https://doaj.org/article/01dfae0657b24788a35aa5ca003c75eb

Syncytia formation by SARS‐CoV‐2‐infected cells

Autor: Julian Buchrieser, Olivier Schwartz, Sylvie van der Werf, Cyril Planchais, Mathieu Hubert, Jérémy Dufloo, Maaran Michael Rajah, Blandine Monel, Nicoletta Casartelli, Delphine Planas, Hugo Mouquet, Florence Guivel-Benhassine, Timothée Bruel, Françoise Porrot

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2020, 39 (23), pp.e106267. ⟨10.15252/embj.2020106267⟩
EMBO Journal, 2020, 39 (23), pp.e106267. ⟨10.15252/embj.2020106267⟩
The EMBO Journal
EMBO J

Severe cases of COVID‐19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms regulating the formation of these syncytia are not well understood. Here, we sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f03651d0f4f101e9b526482460eb63
https://hal-pasteur.archives-ouvertes.fr/pasteur-03253133

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

Autor: Noé Palmic, Lucile Espert, Joelle Tobaly-Tapiero, Arthur Cormier, Pascale Lesage, Baek Kim, Olivier Schwartz, Felipe Diaz-Griffero, Florence Margottin, Si'Ana A. Coggins, Charlotte Martinat, Alessia Zamborlini, Mirijana Persaud, Ali Saïb, Julian Buchrieser, Guillaume Bossis, Nicoletta Casartelli

SAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting the supply of the dNTP substrates. Yet, phosphorylation of T592 downregulates SAMHD1 antiviral activity, but no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6a665d4da9bc960c8b3bb65d2e26594
https://doi.org/10.1101/2020.06.04.133439