Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nicoleta Anghel"'
Autor:
Nicoleta Anghel, Dennis Imhof, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Haenggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 92-106 (2021)
The apicomplexan parasite Neospora caninum is an important causative agent of congenital neosporosis, resulting in abortion, birth of weak offspring and neuromuscular disorders in cattle, sheep, and many other species. Among several compound classes
Externí odkaz:
https://doaj.org/article/d2ab6fc7c7674245a649097532f71673
Autor:
Dennis Imhof, Nicoleta Anghel, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Hänggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss , Pp 90-101 (2021)
Bumped kinase inhibitors (BKIs) target the apicomplexan calcium-dependent protein kinase 1 (CDPK1). BKI-1748, a 5-aminopyrazole-4-carboxamide compound when added to fibroblast cells concomitantly to the time of infection, inhibited proliferation of a
Externí odkaz:
https://doaj.org/article/225361d65821483fab18631218d65033
Autor:
Jessica Ramseier, Dennis Imhof, Kai Pascal Alexander Hänggeli, Nicoleta Anghel, Ghalia Boubaker, Richard M. Beteck, Luis-Miguel Ortega-Mora, Richard K. Haynes, Andrew Hemphill
Publikováno v:
Pathogens, Vol 12, Iss 3, p 447 (2023)
The effects of decoquinate (DCQ) and three O-quinoline-carbamate-derivatives were investigated using human foreskin fibroblasts (HFF) infected with Neospora caninum tachyzoites. These compounds exhibited half-maximal proliferation inhibition (IC50s)
Externí odkaz:
https://doaj.org/article/54d7f83ce6a34fad8ff630573d8953d0
Autor:
Alexandru Petre, Cornel Balta, Hildegard Herman, Sami Gharbia, Ada Codreanu, Bianca Onita-Mladin, Nicoleta Anghel-Zurbau, Andrei-Gelu Hermenean, Simona-Rebeca Ignat, Sorina Dinescu, Iuliana Urzica, Sergiu Drafta, Luminita Oancea, Anca Hermenean
Publikováno v:
Journal of Advanced Research, Vol 28, Iss , Pp 221-229 (2021)
Introduction: Obtaining a certain bone volume is an important goal in implantology or orthopedics. Thus, after tooth extraction, quite a lot of horizontal and vertical alveolar bone is lost in time and can be detrimental to the implant treatment outc
Externí odkaz:
https://doaj.org/article/ffb5f2fff57c4fac8c309d3833c6e104
Autor:
Isabelle Holzer, Oksana Desiatkina, Nicoleta Anghel, Serena K. Johns, Ghalia Boubaker, Andrew Hemphill, Julien Furrer, Emilia Păunescu
Publikováno v:
Molecules, Vol 28, Iss 2, p 902 (2023)
Eight novel carbohydrate-tethered trithiolato dinuclear ruthenium(II)-arene complexes were synthesized using CuAAC ‘click’ (Cu(I)-catalyzed azide-alkyne cycloaddition) reactions, and there in vitro activity against transgenic T. gondii tachyzoite
Externí odkaz:
https://doaj.org/article/9c27ac6421184771a266cf12b3450755
Autor:
Oksana Desiatkina, Martin Mösching, Nicoleta Anghel, Ghalia Boubaker, Yosra Amdouni, Andrew Hemphill, Julien Furrer, Emilia Păunescu
Publikováno v:
Molecules, Vol 27, Iss 23, p 8173 (2022)
Aiming toward compounds with improved anti-Toxoplasma activity by exploiting the parasite auxotrophies, a library of nucleobase-tethered trithiolato-bridged dinuclear ruthenium(II)-arene conjugates was synthesized and evaluated. Structural features s
Externí odkaz:
https://doaj.org/article/5c881f0e08cd461cb544c9248be1170d
Autor:
Pablo Winzer, Dennis Imhof, Nicoleta Anghel, Dominic Ritler, Joachim Müller, Ghalia Boubaker, Adriana Aguado-Martinez, Luis-Miguel Ortega-Mora, Kayode K. Ojo, Wesley C. VanVoorhis, Andrew Hemphill
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Exposure of Neospora caninum tachyzoites to BKI-1294 in vitro results in the formation of long-lived multinucleated complexes (MNCs). However, in vivo treatment of BALB/c mice with BKI-1294 shortly after N. caninum infection during pregnancy was safe
Externí odkaz:
https://doaj.org/article/9d7549d19f33427db0157d875acd6bd4
Autor:
Joachim Müller, Nicoleta Anghel, Dennis Imhof, Kai Hänggeli, Anne-Christine Uldry, Sophie Braga-Lagache, Manfred Heller, Kayode K. Ojo, Luis-Miguel Ortega-Mora, Wesley C. Van Voorhis, Andrew Hemphill
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2381 (2022)
Neospora caninum is an apicomplexan parasite closely related to Toxoplasma gondii, and causes abortions, stillbirths and/or fetal malformations in livestock. Target-based drug development has led to the synthesis of calcium-dependent protein kinase 1
Externí odkaz:
https://doaj.org/article/faee7df41fd643bb96e7a5f7a7f6507b
Autor:
Nicoleta Anghel, Joachim Müller, Mauro Serricchio, Jennifer Jelk, Peter Bütikofer, Ghalia Boubaker, Dennis Imhof, Jessica Ramseier, Oksana Desiatkina, Emilia Păunescu, Sophie Braga-Lagache, Manfred Heller, Julien Furrer, Andrew Hemphill
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10787 (2021)
Toxoplasma gondii is an apicomplexan parasite that infects and proliferates within many different types of host cells and infects virtually all warm-blooded animals and humans. Trypanosoma brucei is an extracellular kinetoplastid that causes human Af
Externí odkaz:
https://doaj.org/article/dcb2982ad9874de9a117c1a32fe85c4b
Autor:
Jessica Ramseier, Dennis Imhof, Nicoleta Anghel, Kai Hänggeli, Richard M. Beteck, Vreni Balmer, Luis-Miguel Ortega-Mora, Roberto Sanchez-Sanchez, Ignacio Ferre, Richard K. Haynes, Andrew Hemphill
Publikováno v:
Molecules, Vol 26, Iss 21, p 6393 (2021)
The quinolone decoquinate (DCQ) is widely used in veterinary practice for the treatment of bacterial and parasitic infections, most notably, coccidiosis in poultry and in ruminants. We have investigated the effects of treatment of Toxoplasma gondii i
Externí odkaz:
https://doaj.org/article/a86f5c8d037a44fca41c7ec06a97d3ad