A Highly Potent and Cellularly Active β-Peptidic Inhibitor of the p53/hDM2 Interaction

Autor: Thierry Kimmerlin, Manfred Auer, Volker Uhl, Roman Bauer, Martin Hintersteiner, Nicole-Claudia Meisner, Geraldine Garavel, Thorsten Schindler, Jan-Marcus Seifert

Publikováno v: ChemBioChem. 10:994-998

New and improved: The incorporation of a 6-chlorotryptophan (6-Cl-Trp) into a beta-peptide (M)-3(14) helix leads to a high-affinity hDM2 inhibitor, as demonstrated by fluorescence fluctuation analysis at single molecule resolution. When conjugated to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360ad8481983ba8ff0239483ff640d84
https://doi.org/10.1002/cbic.200800803

Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR

Autor: Maximilian Woisetschlaeger, Kurt Mueller, Roman Bauer, Lukas Oberer, Johannes Ottl, Nathalie Harrer, Jan-Marcus Seifert, Volker Uhl, Christian Guenat, Martin Hintersteiner, Manfred Auer, Christof Buehler, Serge Moss, Nicole-Claudia Meisner, Hans-Ulrich Naegeli

Publikováno v: Nature Chemical Biology. 3:508-515

Careful regulation of mRNA half-lives is a fundamental mechanism allowing cells to quickly respond to changing environmental conditions. The mRNA-binding Hu proteins are important for stabilization of short-lived mRNAs. Here we describe the identific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4e5c18cef085bd2f8764e95770986f
https://doi.org/10.1038/nchembio.2007.14

Confocal Fluorescence Detection Expanded to UV Excitation: The First Continuous Fluorimetric Assay of Human Steroid Sulfatase in Nanoliter Volume

Autor: Nicole-Claudia Meisner, Peter Nussbaumer, Andreas Neubauer, Melitta Bilban, Stefan Jäger, Andreas Billich, Manfred Auer

Publikováno v: ASSAY and Drug Development Technologies. 2:21-30

Steroid sulfatase is an enzyme that currently enjoys considerable interest as a potential drug target in the treatment of estrogen- and androgen-dependent diseases, in particular breast cancer. We have purified human steroid sulfatase to apparent hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5364c2bb3ea678e2a20c6f9a6a3dfdd
https://doi.org/10.1089/154065804322966289

Highly Complementary Target RNAs Promote Release of Guide RNAs from Human Argonaute2

Autor: Lisa E. Young, David V. Morrissey, Nabanita De, Nicole-Claudia Meisner, Ian J. MacRae, Pick-Wei Lau

Argonaute proteins use small RNAs to guide the silencing of complementary target RNAs in many eukaryotes. Although small RNA biogenesis pathways are well studied, mechanisms for removal of guide RNAs from Argonaute are poorly understood. Here we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddd088b5a23bded2cd169c8b2215e66
https://europepmc.org/articles/PMC3746828/

Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries

Autor: Géza Ambrus, Nicole-Claudia Meisner, Andrew J. S. Knox, Larry Gerace, Martin Hintersteiner, Janna Bednenko, Manfred Auer, Mario Schmied, Hubert Gstach, Jan-Marcus Seifert, Eric Singer

Publikováno v: Hintersteiner, M, Ambrus, G, Bednenko, J, Schmied, M, Knox, A J S, Meisner, N-C, Gstach, H, Seifert, J-M, Singer, E L, Gerace, L & Auer, M 2010, ' Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries ', Acs chemical biology, vol. 5, no. 10, pp. 967-979 . https://doi.org/10.1021/cb100094k

In eukaryotic cells, proteins and RNAs are transported between the nucleus and the cytoplasm by nuclear import and export receptors. Over the past decade, small molecules that inhibit the nuclear export receptor CRM1 have been identified, most notabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2765254f82d1a8cd92036899ffd2166
https://pubmed.ncbi.nlm.nih.gov/20677820