Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nicole Zache"'
Publikováno v:
Cellular Oncology, Vol 30, Iss 5, Pp 411-418 (2008)
Reactivation of the tumor suppressor activity to mutant p53 should trigger massive apoptosis and eliminate tumors. The low molecular weight compounds PRIMA-1 and the structural analog PRIMA-1MET reactivate human mutant p53 in vitro and suppress growt
Externí odkaz:
https://doaj.org/article/c41a8f73bfab44d1ba4f6bc6e7f73f73
Autor:
Vladimir J.N. Bykov, Alexandre Shilov, Monica Hultcrantz, Klas G. Wiman, Galina Selivanova, Nicole Zache, Jan Bergman, Natalia Issaeva
Publikováno v:
The Journal of biological chemistry. 292(48)
Reactivation of mutant p53 is likely to provide important benefits for treatment of chemotherapy- and radiotherapy-resistant tumors. We demonstrate here that the maleimide-derived molecule MIRA-1 can reactivate DNA binding and preserve the active con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2c2e4e2b613d293991efecd8394cf3
https://pubmed.ncbi.nlm.nih.gov/15998635
https://pubmed.ncbi.nlm.nih.gov/15998635
Autor:
Klas G. Wiman, Vladimir J.N. Bykov, Nicole Zache, Pierre Hainaut, Jan Bergman, Jeremy Lambert, Nina Rökaeus, Jinfeng Shen
Publikováno v:
Molecular Oncology
Reactivation of mutant p53 in human tumor cells should induce cell death by apoptosis and thus eliminate the tumor. Several small molecules that reactivate mutant p53 have been identified. Here we show that STIMA-1, a low molecular weight compound wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e3c4d58af67300c42a825e9c6d15a0
https://europepmc.org/articles/PMC5527782/
https://europepmc.org/articles/PMC5527782/
Autor:
Galina Selivanova, Jan Bergman, Vladimir J.N. Bykov, Helene Stridh, Nicole Zache, Jacob Westman, Klas G. Wiman
Publikováno v:
Oncogene. 24(21)
Mutant p53-carrying tumors are often more resistant to chemotherapeutical drugs. We demonstrate here that the mutant p53-reactivating compound PRIMA-1(MET) acts synergistically with several chemotherapeutic drugs to inhibit tumor cell growth. Combine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854e86190a7bcec7550a044550b34dae
https://pubmed.ncbi.nlm.nih.gov/15735745
https://pubmed.ncbi.nlm.nih.gov/15735745