Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Nicole Worms"'
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Akademický článek
Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody
Autor: Florine Seidel, Kees Fluiter, Robert Kleemann, Nicole Worms, Anita van Nieuwkoop, Martien P. M. Caspers, Nikolaos Grigoriadis, Amanda J. Kiliaan, Frank Baas, Iliana Michailidou, Martine C. Morrison
Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionObesity has been linked to vascular dysfunction, cognitive impairment and neurodegenerative diseases. However, experimental models that recapitulate brain pathology in relation to obesity and vascular dysfunction are still lacking.Methods
Externí odkaz: https://doaj.org/article/ce1aa71d47d747e49411fa68f117f960
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3
Akademický článek
Beneficial effects of elafibranor on NASH in E3L.CETP mice and differences between mice and men
Autor: Anita M. van den Hoek, Lars Verschuren, Martien P. M. Caspers, Nicole Worms, Aswin L. Menke, Hans M. G. Princen
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Non-alcoholic steatohepatitis (NASH) is the most rapidly growing liver disease that is nevertheless without approved pharmacological treatment. Despite great effort in developing novel NASH therapeutics, many have failed in clinical trials.
Externí odkaz: https://doaj.org/article/b01d71c202e84e7d903bdef458f54ea0
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4
Akademický článek
Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice[S]
Autor: Marianne G. Pouwer, Elsbet J. Pieterman, Nicole Worms, Nanda Keijzer, J. Wouter Jukema, Jesper Gromada, Viktoria Gusarova, Hans M.G. Princen
Publikováno v: Journal of Lipid Research, Vol 61, Iss 3, Pp 365-375 (2020)
Atherosclerosis-related CVD causes nearly 20 million deaths annually. Most patients are treated after plaques develop, so therapies must regress existing lesions. Current therapies reduce plaque volume, but targeting all apoB-containing lipoproteins
Externí odkaz: https://doaj.org/article/ef5373475cbd46ad9e98e8368ae8f8d0
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5
Akademický článek
A Translational Mouse Model for NASH with Advanced Fibrosis and Atherosclerosis Expressing Key Pathways of Human Pathology
Autor: Anita M. van den Hoek, Lars Verschuren, Nicole Worms, Anita van Nieuwkoop, Christa de Ruiter, Joline Attema, Aswin L. Menke, Martien P. M. Caspers, Sridhar Radhakrishnan, Kanita Salic, Robert Kleemann
Publikováno v: Cells, Vol 9, Iss 9, p 2014 (2020)
Non-alcoholic steatohepatitis (NASH) is a fast-growing liver disorder that is associated with an increased incidence of cardiovascular disease and type 2 diabetes. Animal models adequately mimicking this condition are scarce. We herein investigate wh
Externí odkaz: https://doaj.org/article/8cc64712475b43a2b5da4619dd14b50a
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6
Semaglutide Has Beneficial Effects on Non-Alcoholic Steatohepatitis in Ldlr-/-.Leiden Mice
Autor: José A. Inia, Geurt Stokman, Martine C. Morrison, Nicole Worms, Lars Verschuren, Martien P. M. Caspers, Aswin L. Menke, Louis Petitjean, Li Chen, Mathieu Petitjean, J. Wouter Jukema, Hans M. G. Princen, Anita M. van den Hoek
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 8494
Semaglutide, a glucagon-like peptide-1 receptor agonist, is an antidiabetic medication that has recently been approved for the treatment of obesity as well. Semaglutide is postulated to be a promising candidate for the treatment of non-alcoholic stea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c03971fe33fb61b915f47cb2cdb4f94
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7
Milk fat globule membrane attenuates high fat diet-induced neuropathological changes in obese Ldlr−/−.Leiden mice
Autor: Lonneke van der Logt, Vivienne Verweij, Maximilian Wiesmann, Janna A. van Diepen, Martine C. Morrison, Amanda J. Kiliaan, Gabriele Gross, Nicole Worms, Robert Kleemann, Bram Geenen, Ilse A.C. Arnoldussen, Natàlia Pujol Gualdo, Marijke Voskuilen
Publikováno v: International Journal of Obesity, 46(2), 342-349
International Journal of Obesity, 46, 342-349
International Journal of Obesity, 46(2), 342-349. SPRINGERNATURE
International Journal of Obesity 46 (2022) 2
International Journal of Obesity, 46, 2, pp. 342-349
Item does not contain fulltext BACKGROUND: Milk-fat globule membrane (MFGM) is a complex structure secreted by the mammary gland and present in mammalian milk. MFGM contains lipids and glycoproteins as well as gangliosides, which may be involved in m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda66f54e727b8c7030f8e809ed58320
https://research.wur.nl/en/publications/milk-fat-globule-membrane-attenuates-high-fat-diet-induced-neurop
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10
Beneficial effects of elafibranor on NASH in E3L.CETP mice and differences between mice and men
Autor: Lars Verschuren, Nicole Worms, Martien P. M. Caspers, Aswin L. Menke, Anita M. van den Hoek, Hans M.G. Princen
Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Non-alcoholic steatohepatitis (NASH) is the most rapidly growing liver disease that is nevertheless without approved pharmacological treatment. Despite great effort in developing novel NASH therapeutics, many have failed in clinical trials. This has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974b9f37f8a37fe66273082c561b1890
https://pubmed.ncbi.nlm.nih.gov/33658534
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