Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicole Wille"'
Autor:
Elisa Zanini, Nicole Forster-Gross, Felix Bachmann, Adrian Brüngger, Paul McSheehy, Karine Litherland, Karin Burger, Anna C. Groner, Mila Roceri, Luc Bury, Martin Stieger, Nicole Willemsen-Seegers, Jos de Man, Diep Vu-Pham, Helma W. E. van Riel, Guido J. R. Zaman, Rogier C. Buijsman, Laurenz Kellenberger, Heidi A. Lane
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThreonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) are common essential kinases that collaborate in activating the spindle assembly checkpoint (SAC) at the kinetochore, ensuring appropriate chromosome alignment and segregation pr
Externí odkaz:
https://doaj.org/article/cf9a84a3e06f4b3a99f2975a86de17db
Autor:
Nicole Wille, Dan Friedman
Fathering in all its guises is in the process of transformation, as fathers are both more involved with their families than before, but also still largely considered inferior to mothers in most ways. The essays in this collection explore the underexa
Autor:
Jeffrey J. Kooijman, Wilhelmina E. van Riel, Jelle Dylus, Martine B. W. Prinsen, Yvonne Grobben, Tessa J. J. de Bitter, Antoon M. van Doornmalen, Janneke J. T. M. Melis, Joost C. M. Uitdehaag, Yugo Narumi, Yusuke Kawase, Jeroen A. D. M. de Roos, Nicole Willemsen-Seegers, Guido J. R. Zaman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
During the last two decades, kinase inhibitors have become the major drug class for targeted cancer therapy. Although the number of approved kinase inhibitors increases rapidly, comprehensive in vitro profiling and comparison of inhibitor activities
Externí odkaz:
https://doaj.org/article/8a2b28555c90401aa5082f21d4b9f7f8
Autor:
Marloes A.M. van Dijk, Marc Y. Engelsma, Vanessa X.N. Visser, Ingrid Keur, Marjolijn E. Holtslag, Nicole Willems, Björn P. Meij, Peter T.J. Willemsen, Jaap A. Wagenaar, Hendrik I.J. Roest, Els M. Broens
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 7, Pp 1783-1788 (2021)
Brucella canis had not been isolated in the Netherlands until November 2016, when it was isolated from a dog imported from Romania. Including this case, 16 suspected cases were notified to the authorities during the following 25 months. Of these 16 d
Externí odkaz:
https://doaj.org/article/dd1ac3a2877c47db950b6fbbcd00b6da
Autor:
Yvonne Grobben, Jos de Man, Antoon M. van Doornmalen, Michelle Muller, Nicole Willemsen-Seegers, Diep Vu-Pham, Winfried R. Mulder, Martine B. W. Prinsen, Joeri de Wit, Jan Gerard Sterrenburg, Freek van Cauter, Judith E. den Ouden, Anne M. van Altena, Leon F. Massuger, Joost C. M. Uitdehaag, Rogier C. Buijsman, Guido J. R. Zaman
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Indoleamine 2,3-dioxygenase (IDO1) is a key regulator of immune suppression by catalyzing the oxidation of L-tryptophan. IDO1 expression has been related to poor prognosis in several cancers and to resistance to checkpoint immunotherapies. We describ
Externí odkaz:
https://doaj.org/article/67d223be9e3a4daabf3fe18bdc0d30fd
Autor:
Yvonne Grobben, Joost C.M. Uitdehaag, Nicole Willemsen-Seegers, Werner W.A. Tabak, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100014- (2020)
Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea. Arginase-1 is abundantly expressed by tumor-infiltrating myeloid cells that promote tumor immunosuppression, which is relieved by
Externí odkaz:
https://doaj.org/article/69e071817d594ce39d3c3d4b2449e42f
Autor:
Nicole Willers, Graeme B. Martin, Phill Matson, Peter R. Mawson, Keith Morris, Roberta Bencini
Publikováno v:
Animals, Vol 5, Iss 4, Pp 1329-1344 (2015)
Populations of Australian marsupials can become overabundant, resulting in detrimental impacts on the environment. For example, the threatened black-flanked rock-wallaby ( Petrogale lateralis lateralis ) has previously been perceived as overabundant
Externí odkaz:
https://doaj.org/article/2d0495ffe63c4fd6b112cb029e347da8