Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicole Wetoska"'
Autor:
Leslie A. Rowland, Adilson Guilherme, Felipe Henriques, Chloe DiMarzio, Sean Munroe, Nicole Wetoska, Mark Kelly, Keith Reddig, Gregory Hendricks, Meixia Pan, Xianlin Han, Olga R. Ilkayeva, Christopher B. Newgard, Michael P. Czech
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The function of de novo lipogenesis (DNL) in adipocytes has been a mystery as it contributes little to fat storage in these cells. Here, the authors show that DNL is a critical source of fatty acids for membrane-expanding processes like autophagy.
Externí odkaz:
https://doaj.org/article/e82629e931b04ccc8a420d081396192c
Autor:
Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M. Nicoloro, Mark Kelly, Lawrence M. Lifshitz, Hui Wang, Kyounghee Min, Leslie A. Rowland, Kaltinaitis B. Santos, Nicole Wetoska, Randall H. Friedline, Stacy A. Maitland, Min Chen, Lee S. Weinstein, Scot A. Wolfe, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101780- (2023)
Objectives: Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled respiration in mouse and human adipocytes. We tested whether NRIP1 deficient a
Externí odkaz:
https://doaj.org/article/8509853fb6d444bb83dafa8e5ebf8337
Autor:
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112488- (2023)
Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl
Externí odkaz:
https://doaj.org/article/12bc2d6551c14f2b8d253e56cdc46fc0
Autor:
Leslie A. Rowland, Adilson Guilherme, Felipe Henriques, Chloe DiMarzio, Nicole Wetoska, Mark Kelly, Keith Reddig, Gregory Hendricks, Meixia Pan, Xianlin Han, Olga R. Ilkayeva, Christopher B. Newgard, Michael P. Czech
SummaryAutophagy is a homeostatic degradative process for cell components that enables stress resilience and can determine cellular fate and function. However, lipid sources for the rapid membrane expansions of autophagosomes, the workhorses of autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37cdc662341aa004ce31ddde51ee9278
https://doi.org/10.1101/2022.05.25.493413
https://doi.org/10.1101/2022.05.25.493413
Autor:
Batuhan Yenilmez, Mark Kelly, Guofang Zhang, Nicole Wetoska, Olga R. Ilkayeva, Kyounghee Min, Leslie Rowland, Chloe DiMarzio, Wentao He, Naideline Raymond, Lawrence Lifshitz, Meixia Pan, Xianlin Han, Jun Xie, Randall H. Friedline, Jason K. Kim, Guangping Gao, Mark A. Herman, Christopher B. Newgard, Michael P. Czech
Hepatic steatosis associated with high fat diets, obesity and type 2 diabetes is thought to be the major driver of severe liver inflammation, fibrosis, and cirrhosis. Cytosolic acetyl-coenzyme A (AcCoA), a central metabolite and substrate for de novo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb30d29f5874ce1b0dc85e39ec76c153
https://doi.org/10.1101/2022.03.21.485183
https://doi.org/10.1101/2022.03.21.485183
Autor:
Batuhan Yenilmez, Mark Kelly, Guo-Fang Zhang, Nicole Wetoska, Olga R. Ilkayeva, Kyounghee Min, Leslie Rowland, Chloe DiMarzio, Wentao He, Naideline Raymond, Lawrence Lifshitz, Meixia Pan, Xianlin Han, Jun Xie, Randall H. Friedline, Jason K. Kim, Guangping Gao, Mark A. Herman, Christopher B. Newgard, Michael P. Czech
Publikováno v:
Journal of Biological Chemistry. 298:102401
Hepatic steatosis associated with high-fat diet, obesity, and type 2 diabetes is thought to be the major driver of severe liver inflammation, fibrosis, and cirrhosis. Cytosolic acetyl CoA (AcCoA), a central metabolite and substrate for de novo lipoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6790653fb5e729614a6e6b4d1c75f3
https://doi.org/10.1016/j.jbc.2022.102401
https://doi.org/10.1016/j.jbc.2022.102401
Autor:
Xianlin Han, Meixia Pan, Nicole Wetoska, Michael A. Brehm, Matthew R. Hassler, Dimas Echeverria, Nicholas McHugh, Samuel R. Hildebrand, Mark J. S. Kelly, Batuhan Yenilmez, Julia F. Alterman, Lorenc Vangjeli, Kyounghee Min, Anastasia Khvorova, Chloe DiMarzio, Jacquelyn Sousa, Lawrence M. Lifshitz, Michael P. Czech
Publikováno v:
Molecular therapy. Nature Publishing Group
Nonalcoholic steatohepatitis (NASH) is a severe liver disorder characterized by triglyceride accumulation, severe inflammation, and fibrosis. With the recent increase in prevalence, NASH is now the leading cause of liver transplant, with no approved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2483184af15f9f733205ac47ad9672a
https://doi.org/10.1016/j.ymthe.2021.11.007
https://doi.org/10.1016/j.ymthe.2021.11.007