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Akademický článek

A Comparison of the Frequency of Trisomy 13, 18, and 21 Using Non-Invasive Prenatal Testing According to Diminished vs. Normal Egg Reserve and Age

Autor: Brooke Neumann, Nicole Weitz, Jerome H. Check, Carrie Wilson, Ann Diantonio, Megan O’Neil

Publikováno v: Reproductive Medicine, Vol 5, Iss 2, Pp 81-89 (2024)

Background: This study’s aim was to determine whether diminished oocyte reserve (DOR) increases the risk of having a fetus with trisomy 13, 18, or 21 at 10 weeks as evaluated by non-invasive prenatal testing (NIPT) and to evaluate the confounding e

Externí odkaz: https://doaj.org/article/293862ed15fe46a495ffd488e4dd1a54

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Akademický článek

A disease concept model for STXBP1‐related disorders

Autor: Katie R. Sullivan, Sarah M. Ruggiero, Julie Xian, Kim M. Thalwitzer, Rahma Ali, Sydni Stewart, Mahgenn Cosico, Jackie Steinberg, James Goss, Anna C. Pfalzer, Kyle J. Horning, Nicole Weitzel, Sydney Corey, Laura Conway, Charlene Son Rigby, Terry Jo Bichell, Ingo Helbig

Publikováno v: Epilepsia Open, Vol 8, Iss 2, Pp 320-333 (2023)

Abstract Objective STXBP1‐related disorders are rare genetic epilepsies and neurodevelopmental disorders, but the impact of symptoms across clinical domains is poorly understood. Disease concept models are formal frameworks to assess the lived expe

Externí odkaz: https://doaj.org/article/8198dab77bef450281e40e20c2430f6a

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Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

Publikováno v: Nature Communications 9, 697 (2018). doi:10.1038/s41467-017-02688-6
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-22 (2018)

T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characteriz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5b78d8e81fb4908b8ea1150da72e09
http://hdl.handle.net/10138/234167

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Models for mature T-cell lymphomas—A critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts

Autor: Nabil Al-Ghaili, Sebastian Newrzela, Vaia Florou, Kathrin Warner, Nicole Weit, Marco Herling, Giuliano Crispatzu, M. James You

Publikováno v: Critical Reviews in Oncology/Hematology. 88:680-695

Mature T-cell lymphomas/leukemias (MTCL) have been understudied lymphoid neoplasms that currently receive growing attention. Our historically rudimentary molecular understanding and dissatisfactory interventional success in this complex and for the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c88e0cd18d6f01af4a949f933749e20
https://doi.org/10.1016/j.critrevonc.2013.07.014

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T-Cell Receptor Signaling in Peripheral T-Cell Lymphoma – A Review of Patterns of Alterations in a Central Growth Regulatory Pathway

Autor: Kathrin Warner, Nicole Weit, Joan H. Admirand, Giuliano Crispatzu, Dan Jones, Marco Herling

Publikováno v: Current Hematologic Malignancy Reports. 8:163-172

T-cell receptor (TCR) signaling is pivotal in T-cell development and function. In peripheral T-cell lymphomas/leukemias (PTCL/L), histogenesis, transforming events, epidemiology, and clinical presentation are also closely linked to TCR-mediated influ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0058024799a92b45d58dbde7fdaaef8f
https://doi.org/10.1007/s11899-013-0165-2

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Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-cell prolymphocytic leukemia

Autor: Gabriele Kandler, Dirk Winkler, Georg Hopfinger, Barbara Eichhorst, Stephan Stilgenbauer, Hartmut Döhner, Marco Herling, Anna-Maria Fink, Nicole Weit, Natali Pflug, Paula Cramer, Raymonde Busch, Anne Westermann, Michael Hallek, Nina Reinart, Guenter Fingerle-Rowson

Publikováno v: Cancer. 119:2258-2267

Background Scarce systematic trial data have prevented uniform therapeutic guidelines for T-cell prolymphocytic leukemia (T-PLL). A central need in this historically refractory tumor is the controlled evaluation of multiagent chemotherapy and its com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b042604fd6e74183e72cbf8b9cef416
https://doi.org/10.1002/cncr.27972

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A PP4 Holoenzyme Balances Physiological and Oncogenic Nuclear Factor-Kappa B Signaling in T Lymphocytes

Autor: Felice Frey, Nina Booken, Markus Brechmann, Thomas Mock, Wolfgang W. Müller, Peter H. Krammer, Rüdiger Arnold, Nicole Weit, Guido H. Wabnitz, Michael Boutros, Yvonne Samstag, Jan P. Nicolay, Dorothee Nickles, Claus Detlev Klemke, Michael K. Kiessling, Rebecca Breuer, Marco Herling

Publikováno v: Immunity. 37(4):697-708

SummarySignal transduction to nuclear factor-kappa B (NF-κB) involves multiple kinases and phosphorylated target proteins, but little is known about signal termination by dephosphorylation. By RNAi screening, we have identified protein phosphatase 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f971622cb1ebbc98721f162b8a2ec75

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Recent developments in the treatment of peripheral T-cell lymphoma

Autor: Georg Hopfinger, Marco Herling, Nicole Weit

Publikováno v: memo - Magazine of European Medical Oncology. 3:73-76

Peripheral T-cell lymphomas (PTCL) comprise a heterogeneous group of lymphatic neoplasms, which originate from mature (post-thymic) T-cells. Although comprising less than 15% of all non-Hodgkin lymphomas (NHL) in adults in Western countries, T-cell l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb5257e8e36dca6d623d4f3317484f34
https://doi.org/10.1007/s12254-010-0191-x

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