Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nicole Vantuno"'
Autor:
Michael G. Murray, Bernard R. Neustadt, Julie M. Strizki, Sue-Ing Lin, Nicole Vantuno, Lisa Wojcik, Jayaram R. Tagat, Kathleen Cox, and Bahige M. Baroudy, Steensma Ruo, Dennis V. Nazareno, Stuart W. McCombie, Serena Xu
Publikováno v:
Journal of Medicinal Chemistry. 44:3343-3346
Truncation of the original piperidino-2(S)-methyl piperazine lead structure 2, from a family of muscarinic antagonists, gave compound 8 which has improved selectivity for the HIV-1 co-receptor CCR5 over muscarinic receptors. Further optimization for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d3fd3d509d230c7eb1b4a8a60a7827
https://doi.org/10.1021/jm0155401
https://doi.org/10.1021/jm0155401
Autor:
Dennis V. Nazareno, Stuart W. McCombie, Bahige M. Baroudy, Jayaram R. Tagat, Steensma Ruo, Serena Xu, Sue-Ing Lin, Nicole Vantuno, Jia Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2143-2146
Optimization of the piperidino-piperazines 1 and 2 provided early leads 3 and 4, which showed good activity in the CCR5–RANTES binding assay and in antiviral assays. A systematic study around these structures showed that the 2(S)-methyl piperazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa9f48d8d60af12dd8a81e32c5ce804
https://doi.org/10.1016/s0960-894x(01)00381-x
https://doi.org/10.1016/s0960-894x(01)00381-x
Autor:
Sue-Ing Lin, Dennis V. Nazareno, Jia Liu, Serena Xu, Jayaram R. Tagat, Nicole Vantuno, Steensma Ruo, Bahige M. Baroudy, Stuart W. McCombie
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a85e6cebc20c17cb4949e2bea0e9dd1
https://doi.org/10.1002/chin.200145175
https://doi.org/10.1002/chin.200145175