Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nicole V. Acuff"'
Autor:
Jerod L. Ptacin, Lina Ma, Carolina E. Caffaro, Nicole V. Acuff, Kristine Germar, Peter Severy, Yanyan Qu, Jose-Luis Vela, Xinming Cai, Kristine M. San Jose, Hans R. Aerni, David B. Chen, Ean Esche, Taylor K. Ismaili, Rob Herman, Yelena Pavlova, Michael J. Pena, Jasmine Nguyen, Lilia K. Koriazova, Laura K. Shawver, Ingrid B. Joseph, Jill Mooney, Mark Peakman, Marcos E. Milla
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-16 (2024)
Abstract Background Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise for treatment of aut
Externí odkaz:
https://doaj.org/article/224e433676bd420da232e1c317680a2d
Autor:
Jerod L. Ptacin, Carolina E. Caffaro, Lina Ma, Kristine M. San Jose Gall, Hans R. Aerni, Nicole V. Acuff, Rob W. Herman, Yelena Pavlova, Michael J. Pena, David B. Chen, Lilia K. Koriazova, Laura K. Shawver, Ingrid B. Joseph, Marcos E. Milla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in hum
Externí odkaz:
https://doaj.org/article/1eeb5f339edc4637a3c9f0f0c17dcf95
Autor:
Kristine M San Jose Gall, Marcos Milla, Caffaro Carolina E, Michael J. Pena, Laura K. Shawver, Ingrid B. Joseph, Ptacin Jerod, David B. Chen, Nicole V Acuff, Lina Ma, Lilia K. Koriazova, Yelena Pavlova, Hans R. Aerni, Rob W Herman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
The implementation of applied engineering principles to create synthetic biological systems promises to revolutionize medicine, but application of fundamentally redesigned organisms has thus far not impacted practical drug development. Here we utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5732ddaedc3b48d14ed6d810fb3614aa
https://doaj.org/article/1eeb5f339edc4637a3c9f0f0c17dcf95
https://doaj.org/article/1eeb5f339edc4637a3c9f0f0c17dcf95
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119885 (2015)
Autoimmune diseases are approaching epidemic levels, estimated to affect 5-8% of the population. A number of autoimmune diseases are believed to be driven by autoreactive T cells, specifically by T helper 1 (Th1) cells and T helper 17 (Th17) cells. O
Externí odkaz:
https://doaj.org/article/ab675511a1a64658a65336a2318f1e53
Autor:
Nicole V. Acuff, Joel Linden
Publikováno v:
The Journal of Immunology. 198:4539-4546
High-dimensional flow cytometry is proving to be valuable for the study of subtle changes in tumor-associated immune cells. As flow panels become more complex, detection of minor immune cell populations by traditional gating using biaxial plots, or i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::410128e5a5e49975867d0345ba880ca5
https://doi.org/10.4049/jimmunol.1602077
https://doi.org/10.4049/jimmunol.1602077
Autor:
Wendy T. Watford, Xin Li, Rebecca Kirkland, Kara D. Wyatt, Nicole V. Acuff, Tamas Nagy, Angela R. Peeks
Publikováno v:
Journal of Biological Chemistry. 291:16802-16815
The serine/threonine kinase tumor progression locus 2 (Tpl2, also known as Map3k8/Cot) is a potent inflammatory mediator that drives the production of TNFα, IL-1β, and IFNγ. We previously demonstrated that Tpl2 regulates T cell receptor (TCR) sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c83686e8eee515350abb3bc30d1668
https://doi.org/10.1074/jbc.m116.718783
https://doi.org/10.1074/jbc.m116.718783
Publikováno v:
Infection and immunity. 85(10)
Tumor progression locus 2 (Tpl2) is a serine-threonine kinase that regulates Th1 differentiation, secretion of the inflammatory cytokine gamma interferon (IFN-γ), and host defense against the intracellular pathogens Toxoplasma gondii , Listeria mono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9119985eaf83a878e45af27da8f18d14
https://pubmed.ncbi.nlm.nih.gov/28760932
https://pubmed.ncbi.nlm.nih.gov/28760932
Autor:
Nicole V, Acuff, Joel, Linden
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 198(11)
High-dimensional flow cytometry is proving to be valuable for the study of subtle changes in tumor-associated immune cells. As flow panels become more complex, detection of minor immune cell populations by traditional gating using biaxial plots, or i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8fd68e77f62b2f85836e42016bdaf77b
https://pubmed.ncbi.nlm.nih.gov/28468972
https://pubmed.ncbi.nlm.nih.gov/28468972
Publikováno v:
The Journal of Immunology. 202:64.15-64.15
Human TLR9 (CD289) is a well characterized mediator of antiviral immunity. TLR9 is primarily activated by unmethylated CpG sequences leading to the production of type I interferons and other inflammatory cytokines. Recently, changes in TLR9 expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3672ca69b543e899d8d25ebe014b9883
https://doi.org/10.4049/jimmunol.202.supp.64.15
https://doi.org/10.4049/jimmunol.202.supp.64.15
Publikováno v:
Journal of leukocyte biology. 101(6)
Tumor progression locus 2 (Tpl2) is a serine/threonine kinase that promotes inflammatory cytokine production by activating the MEK/ERK pathway. Tpl2 has been shown to be important for eliciting the inflammatory properties of macrophages; however, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5171f305b7734f814c2d1e0a1e3bf6ff
https://pubmed.ncbi.nlm.nih.gov/28356348
https://pubmed.ncbi.nlm.nih.gov/28356348