Výsledky vyhledávání - "Nicole Ungerer"

Reversal of Pathologic Lipid Accumulation in NPC1-Deficient Neurons by Drug-Promoted Release of LAMP1-Coated Lamellar Inclusions

Autor: Martine Perraut, Valérie Demais, Céline Keime, Amélie Barthélémy, Frank W. Pfrieger, Nicole Ungerer, Sophie Reibel

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2016, 36 (30), ⟨10.1523/JNEUROSCI.0900-16.2016⟩

Aging and pathologic conditions cause intracellular aggregation of macromolecules and the dysfunction and degeneration of neurons, but the mechanisms are largely unknown. Prime examples are lysosomal storage disorders such as Niemann-Pick type C (NPC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a347f031258fe9d98352951b85d7da12
https://doi.org/10.1523/jneurosci.0900-16.2016

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Activation and desensitization of the olfactory cAMP-gated transduction channel: identification of functional modules

Autor: Frank Möhrlen, Nicole Ungerer, Kerstin Vocke, Clemens Waldeck, Stephan Frings

Publikováno v: The Journal of General Physiology

Olfactory receptor neurons respond to odor stimulation with a receptor potential that results from the successive activation of cyclic AMP (cAMP)-gated, Ca2+-permeable channels and Ca2+-activated chloride channels. The cAMP-gated channels open at mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab28c9c19b888b6451f9919dce411d0b
https://doi.org/10.1085/jgp.200910296

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Cholesterol metabolism in neurons and astrocytes

Autor: Frank W. Pfrieger, Nicole Ungerer

Publikováno v: Progress in lipid research
Progress in lipid research, 2011, 50 (4), pp.357-371. ⟨10.1016/j.plipres.2011.06.002⟩

Cells in the mammalian body must accurately maintain their content of cholesterol, which is an essential membrane component and precursor for vital signalling molecules. Outside the brain, cholesterol homeostasis is guaranteed by a lipoprotein shuttl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff1f00f69c3fe64d27fe9f867b2073a
https://pubmed.ncbi.nlm.nih.gov/21741992

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Proteomic analysis of a membrane preparation from rat olfactory sensory cilia

Autor: Ulrich Mayer, Uwe Warnken, Daniel Klimmeck, Frank Möhrlen, Nicole Ungerer, Stephan Frings, Martina Schnölzer

Publikováno v: Chemical senses. 33(2)

The cilia of mammalian olfactory receptor neurons (ORNs) represent the sensory interface that is exposed to the air within the nasal cavity. The cilia are the site where odorants bind to specific receptors and initiate olfactory transduction that lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ceff7dba2a3c89b2b288fadddef7925
https://pubmed.ncbi.nlm.nih.gov/18032372

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Calcium-signaling networks in olfactory receptor neurons

Autor: Nicole Ungerer, Stephan Frings, Ulrich Mayer, Uwe Warnken, Daniel Klimmeck, Frank Möhrlen, Martina Schnölzer

Publikováno v: Neuroscience. 151(3)

The olfactory neuroepithelium represents a unique interface between the brain and the external environment. Olfactory function comprises a distinct set of molecular tasks: sensory signal transduction, cytoprotection and adult neurogenesis. A multitud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeba74c7f1494979fbc5f89ec8b09f7f
https://pubmed.ncbi.nlm.nih.gov/18155848

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